1,464 research outputs found
David Fable Books No 1
No full textThere are five stories in this book. I ordered this one for the collection because of the title of the first: The Story of Anna, Buddy, and the Country Mouse. That story is utterly charming, together with its colored lithographs. The author frequently pauses to note to the reader elements of a picture that the reader might miss. There is a first visit to a town, complete with a visit to a restaurant for tea, but in this case the two dogs sit nicely at a table and order, while Homer the mouse gets on top of the table. The three then again travel by bus back to the country. The five stories are interspersed with illustrations for traditional rhymes, including Sing a Song of Sixpence. Indeed, it is the art that makes this book, along with the charm of whimsical local stories. Coppin was serving in the armed forces overseas during World War II and wrote these stories for his son David, to whom the book is dedicated. There is a picture of David facing the Publisher's Introduction at the book's beginning.This is a hardbound book (hard cover)Alan Middleton Coppi
The safety and effectiveness of different methods of ear wax removal: a systematic review and economic evaluation
No full textEar wax (cerumen) is a natural secretion produced to protect the inner ear from dirt and other fragments by moving these particles towards the outer ear. If this process does not happen properly, wax may build up causing blockage in the ear canal and the possibility of impaction. People with a build up of ear wax may suffer from hearing loss, discomfort and, on occasions, infection. It may present problems in assessing hearing, blocking the view of the ear drum during medical examination and interfering with the fitting or function of hearing aids. Although it is thought to affect between 2% and 6% of the population in the England and Wales, some groups may be at a higher risk, such as those using hearing aids or with small ear canals and/or skin conditions. Recurrence is thought to be high among some of these groups. The consequences of the build up of ear wax in the ear canal are thought to be a common reason for consultation and cost in general practice with over 2 million consultations per year in the NHS.Methods of removal of ear wax include drops, flushing with water in general practice, and removal with suction or probes in specialist clinics. The relative safety and benefits of these different methods of removal remains uncertain. This research will systematically review published and unpublished evidence on the clinical and cost effectiveness of different methods for the removal of ear wax. Where appropriate, it will develop an economic model using data from this systematic review and other relevant sources to estimate the relative costs and benefits of different methods. In addition, the project will provide recommendations for future research to try to help answer any remaining areas of uncertainty
Youth consultation-liaison psychiatry: How can we improve outcomes for young people with chronic illness?
No full textStephen Allison, Bernhard T Baune, Leigh Roeger, Brian Coppin, Tarun Bastiampillai and Richard Ree
Youth hub-and-spoke model
No full textStephen Allison, Bernhard T Baune, Leigh Roeger, Brian Coppin, Tarun Bastiampillai, Richard Ree
Randomized trial of bulb syringes for earwax: impact on health service utilization
No full textPurpose: Bulb syringes can be used for the self-clearance of earwax and, in the short term, appear effective. We compared the long-term effectiveness of self-irrigation using a bulb syringe with routine care in United Kingdom (UK) family practice clinics where irrigating ears to remove wax is a common procedure. Methods: We assessed the impact on health service utilization as a follow-up to a single-blind, randomized, controlled trial of 237 patients attending 7 UK family practice clinics with symptomatic, occluding earwax who were randomized to an intervention group (ear drops, bulb syringe, instructions on its use and reuse) or a control group (ear drops, then clinic irrigation). After 2 years, a retrospective notes search for earwax-related consultations was carried out. We used an intention-to-treat analysis to assess differences in dichotomous outcomes between groups. Results: In the 2-year trial follow-up, more control group patients returned with episodes of earwax: 85 of 117 (73%) control vs 70 of 117 (60%) intervention, 2=4.30; P = .038; risk ratio 1.21 (95% CI, 1.01–1.37). The numbers of consultations amounted to 1.15 (control) vs 0.64 (intervention) (incidence rate ratio 1.79; 95% CI, 1.05–3.04, P = .032), ie, a difference of 0.50 consultations, thus saving a consultation on average for every 2 people. Conclusion: For patients who have not already tried bulb syringes, self-irrigation using a bulb syringe significantly reduces subsequent demand for ear irrigation by health professionals. Advocating the initial use of bulb syringes could reduce demand for ear irrigation in family practice clinics. <br/
A study of the nutritional and medicinal values of Moringa oleifera leaves from sub-Saharan Africa: Ghana, Rwanda, Senegal and Zambia
No full textMoringa oleifera is an important multipurpose tropical tree under-recognized for its nutritional and medicinal properties. Leaves of M. oleifera collected from the sub-Saharan African countries of Ghana, Rwanda, Senegal and Zambia were analyzed for their nutritional value and bioactivity by UV-Vis spectrophotometry and HPLC coupled with UV and MS detectors. Moringa leaves were found to provide low amounts of vitamin C (0.351 ± 0.046 to 0.749 ± 0.014 mg/100g DW (DW)) as determined using UV spectrophotometry. Using LC/MS, We identified α- and γ- tocopherols, α- and β- carotenes, six analogues of chlorogenic acid including 4 caffeoylquinic acids and 2 coumaroylquinic acids (structural and/or spatial isomers), and chlorogenic acid was used as the standard to estimate the amount of these six phenolic acids. Chlorogenic acid was used as the standard to estimate the amount of these six cumulative isomers by LC/MS. Additionally, in Moringa leaves we detected one sample containing as many as 12 flavonoids including quercetin and kaempferol glycosides with malonyl, acetyl and succinoyl acylations, among which; quercetin and kaempferol glucosides and glucoside malonates are the major constituents based on analysis of their UV and MS data. Using LC/UV/MS, the quercetin and kaempferol aglycones of quercetin and kaempferol in acidic hydrolyzed extracts were successfully separated within 10 min and individually quantitated. A total of 25 samples were assayed for the chlorogenic acid isomers analogs (0.181 to 0.414 mg/100 g DW), tocopherols (7.1 to 116 mg/100 g DW), carotenoids (4.49 to 45.94 mg/100 g DW) and flavonoids (0.179 to 1.643 % g DW). The concentrations of these phytochemicals varied according to the environment, country of collection, genetics, and variety of Moringa oleifera. The nutritional and natural products characterization of Moringa conducted in this study show that the leaves of this plant can contribute significantly to the daily recommended allowance needed for many vitamins and mineral needs as well as serve as a rich source of polyphenols, confirming the importance and role that Moringa can play to improve the health and nutrition particularly in malnourished populations.M.S.Includes bibliographical references (p. 102-113)
Testing the evolutionary link between submillimetre galaxies and quasars: CO observations of QSOs at z~2
No full textWe have used the IRAM Plateau de Bure millimetre interferometer and the UKIRT 1–5 μm Imager Spectrometer (UIST) to test the connection between the major phases of spheroid growth and nuclear accretion by mapping CO emission in nine submillimetre-detected QSOs at z= 1.7–2.6 with black hole (BH) masses derived from near-infrared spectroscopy. When combined with one QSO obtained from the literature, we present sensitive CO(3–2) or CO(2–1) observations of 10 submillimetre-detected QSOs selected at the epoch of peak activity in both QSOs and submillimetre (submm) galaxies (SMGs). CO is detected in 5/6 very optically luminous (MB∼−28) submm-detected QSOs with BH masses MBH≃ 109–1010 M⊙, confirming the presence of large gas reservoirs of Mgas≃ 3.4 × 1010 M⊙. Our BH masses and dynamical mass constraints on the host spheroids suggest, at face value, that these optically luminous QSOs at z= 2 lie about an order of magnitude above the local BH–spheroid relation, MBH/Msph, although this result is dependent on the size and inclination of the CO-emitting region. However, we find that their BH masses are ∼30 times too large and their surface density is ∼300 times too small to be related to typical SMGs in an evolutionary sequence. Conversely, we measure weaker CO emission in four fainter (MB∼−25) submm-detected QSOs with properties, BH masses (MBH≃ 5 × 108 M⊙), and surface densities similar to SMGs. These QSOs appear to lie near the local MBH/Msph relation, making them plausible ‘transition objects’ in the proposed evolutionary sequence linking QSOs to the formation of massive young galaxies and BHs at high redshift. We show that SMGs have a higher incidence of bimodal CO line profiles than seen in our QSO sample, which we interpret as an effect of their relative inclinations, with the QSOs seen more face-on. Finally, we find that the gas masses of the four fainter submm-detected QSOs imply that their star formation episodes could be sustained for ∼10 Myr, and are consistent with representing a phase in the formation of massive galaxies which overlaps a preceding SMG starburst phase, before subsequently evolving into a population of present-day massive ellipticals
Dietary sodium intake relates to vascular health in children with type 1 diabetes
No full textBackground and Objective: Children with type 1 diabetes (T1D) have vascular dysfunction and frequently struggle to adhere to dietary recommendations. Limited data exist for the vascular consequences of poor diet quality in children. We aimed to evaluate the association between dietary components and vascular function in children with T1D. Methods: Cross‐sectional study including 90 children (13.6 [3.5] years, 41 boys) with T1D. They had evaluation of dietary micro and macronutrients (Australian Child and Adolescent Eating Survey), vascular endothelial and smooth muscle function (flow‐mediated dilatation and glyceryl trinitrate mediated dilatation [GTN], respectively), clinical and biochemical variables. Results: Children had a sodium intake of 3.013 (0.76) (mean [SD]) g/day. Vascular smooth muscle dysfunction, as measured by GTN, related to higher daily sodium intake (r = −0.31, P = .003), independent of the inverse relationships between GTN and total energy (r = −0.30, P = .005) and fat intake (r = −0.28, P = .007). Multiregression model showed that an increase in 1 g of daily sodium intake was independently associated with a deterioration of 3 percentage units in GTN (95% CI −4.3, −0.9; P = .003). There was an association between sodium intake and systolic blood pressure after adjustment for age and gender (regression coefficient 2.4; 95% CI 0.5, 4.3; P = .01). Conclusions: High dietary sodium intake in children with T1D is common and relates to vascular dysfunction, independently of other dietary intake, blood pressure, and glycemic control.Jemma Anderson, Jennifer J Couper, Sarah Toome, Christine Mpundu‐Kaambwa, Lynne C Giles, Roger Gent, Brian Coppin, Alexia S Peñ
- …
