163,533 research outputs found
No. 654 Christopher R. Johnson
No full textTranscript (46, 55 pages) of two interviews by Anne P. Peterson with Christopher R. Johnson, director of the Scientific Computing Institute, on 21 September and 18 October 2011. Part of the University Oral History Project, Everett Cooley Collection tape numbers U-3086 and U-3092Christopher Johnson (b. 1960) was born in Kansas City, Kansas. His father was in the Air Force so he and his family moved around a lot when he was young. He went to high school and did his undergraduate in Dayton, Ohio. Christopher then earned his master´s in physics and a PhD in biophysics and computing from the University of Utah. Before working at the University of Utah, he was a professor of physics at Westminster for four years. He describes several positions he held at the University of Utah. Christopher talks about his time working at Sperry Corporation. He describes his involvement with the ACCESS program at the University of Utah.In his second interview, Christopher talks about his time as a research assistant professor, assistant professor, and then associate chairman of the department of computer sciences at the University of Utah. He describes research projects he was involved in. Christopher explains interactive scientific visualization. He talks about his time as director of the Center for Scientific Computing and Imaging. He also worked for the Department of Energy. He talks about his involvement with the University of Utah´s school of computing. Christopher talks about the start-up he founded, Visual Influence.Project: University Oral History Project. Interviewer: Anne Peterso
R. Anthony Reese and Christopher Leslie
No full textChristopher Leslie is a Chancellor’s Professor of Law at UCI Law, and a member of the school’s founding faculty. R. Anthony Reese is a Chancellor’s Professor of Law at UCI Law, and a member of the school’s founding faculty.https://scholarship.law.uci.edu/uci_law_stories_videos_video-interviews_ucilawfaculty/1010/thumbnail.jp
Christopher Rudd, 46
No full textChristopher R. Rudd, a Redwood City resident who grew up in Palo Alto has died. He was 46
Christopher R. Pauley in a Senior Recital
No full textThis is the program for the senior voice recital of Christopher R. Pauley, accompanied by Patti Bryant on piano and Cynthia Miles on the French horn. The recital was held on March 20, 1990, in the Mabee Fine Arts Center Recital Hall
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate
No full textBisphosphonates are the most prescribed preventative treatment for osteoporosis. However, their long-term use has recently been associated with atypical fractures of cortical bone in patients who present with low-energy induced breaks of unclear pathophysiology. The effects of bisphosphonates on the mechanical properties of cortical bone have been exclusively studied under simple, monotonic, quasi-static loading. This study examined the cyclic fatigue properties of bisphosphonate-treated cortical bone at a level in which tissue damage initiates and is accumulated prior to frank fracture in low-energy situations. Physiologically relevant, dynamic, 4-point bending applied to beams (1.5 mm × 0.5 mm × 10 mm) machined from dog rib (n=12/group) demonstrated mechanical failure and micro-architectural features that were dependent on drug dose (3 groups: 0, 0.2, 1.0mg/kg/day; alendronate [ALN] for 3 years) with cortical bone tissue elastic modulus (initial cycles of loading) reduced by 21% (p<0.001) and fatigue life (number of cycles to failure) reduced in a stress-life approach by greater than 3-fold with ALN1.0 (p<0.05). While not affecting the number of osteons, ALN treatment reduced other features associated with bone remodeling, such as the size of osteons (-14%; ALN1.0: 10.5±1.8, VEH: 12.2±1.6, ×10(3) μm2; p<0.01) and the density of osteocyte lacunae (-20%; ALN1.0: 11.4±3.3, VEH: 14.3±3.6, ×10(2) #/mm2; p<0.05). Furthermore, the osteocyte lacunar density was directly proportional to initial elastic modulus when the groups were pooled (R=0.54, p<0.01). These findings suggest that the structural components normally contributing to healthy cortical bone tissue are altered by high-dose ALN treatment and contribute to reduced mechanical properties under cyclic loading conditions.NOTICE: this is the author's version of a work that was accepted for publication in Bone. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bone, Volume 64 (July 2014) DOI: 10.1016/j.bone.2014.03.045Peer reviewe
Christopher Smit
No full textChristopher R. Smit is a faculty member at Calvin College teaching courses in Communication Arts and Sciences. He has written and spoken on media and culture. His last cd St range Train was independently released
American Society of Biomechanics Journal of Biomechanics Award 2013: Cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures
No full textThe biomechanics literature contains many well-understood mechanisms behind typical fracture types that have important roles in treatment planning. The recent association of "atypical" fractures with long-term use of drugs designed to prevent osteoporosis has renewed interest in the effects of agents on bone tissue-level quality. While this class of fracture was recognized prior to the introduction of the anti-resorptive bisphosphonate drugs and recently likened to stress fractures, the mechanism(s) that lead to atypical fractures have not been definitively identified. Thus, a causal relationship between these drugs and atypical fracture has not been established. Physicians, bioengineers and others interested in the biomechanics of bone are working to improve fracture-prevention diagnostics, and the design of treatments to avoid this serious side-effect in the future. This review examines the mechanisms behind the bone tissue damage that may produce the atypical fracture pattern observed increasingly with long-term bisphosphonate use. Our recent findings and those of others reviewed support that the mechanisms behind normal, healthy excavation and tunnel filling by bone remodeling units within cortical tissue strengthen mechanical integrity. The ability of cortical bone to resist the damage induced during cyclic loading may be altered by the reduced remodeling and increased tissue age resulting from long-term bisphosphonate treatment. Development of assessments for such potential fractures would restore confidence in pharmaceutical treatments that have the potential to spare millions in our aging population from the morbidity and death that often follow bone fracture.Peer reviewe
On display: Dr Christopher Marshall
No full textDeposited with permission of Museums Australia (Victoria)An interview with Dr. Christopher R. Marshall, senior lecturer in Art History and Museum Studies at the University of Melbourne
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