11,523 research outputs found
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
No full textGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
SUBCONTRACTING, R&D AND LABOUR PRODUCTIVITY: A THEORETICAL EXPLANATION
No full textWhile a large body of researches discusses the effects of international subcontracting on firm dynamics, the present work deals with the similar issues of a domestic firm who subcontracts to the informal sector in a typical developing world. Theoretically, we develop a model that if the formal sector wage is higher than that of informal sector, the choice of informal sector subcontracting and in-house R&D investment appears to be alternative options to the firm to bypass expensive labour in the formal sector. We argue that the R&D and labour productivity in formal sector are highly influenced by the informal wage but not the formal sector one. Since the subcontracting can raise both supply and demand for informal workers due to a rise of formal sector wage, the movement of informal sector wage is uncertain and thereby, the formal sector R&D and labour-productivity are also ambiguous. Thus, countries with a vast segment of lowly-paid informal workers exhibit lowly-productive formal workers.Subcontracting, Informal Wage, Poverty, Labour Productivity, R&D
A low-complexity ECG feature extraction algorithm for mobile healthcare applications
No full textThis paper introduces a low-complexity algorithm for the extraction of the fiducial points from the Electrocardiogram (ECG). The application area we consider is that of remote cardiovascular monitoring, where continuous sensing and processing takes place in low-power, computationally constrained devices, thus the power consumption and complexity of the processing algorithms should remain at a minimum level. Under this context, we choose to employ the Discrete Wavelet Transform (DWT) with the Haar function being the mother wavelet, as our principal analysis method. From the modulus-maxima analysis on the DWT coefficients, an approximation of the ECG fiducial points is extracted. These initial findings are complimented with a refinement stage, based on the time-domain morphological properties of the ECG, which alleviates the decreased temporal resolution of the DWT. The resulting algorithm is a hybrid scheme of time and frequency domain signal processing. Feature extraction results from 27 ECG signals from QTDB, were tested against manual annotations and used to compare our approach against the state-of-the art ECG delineators. In addition, 450 signals from the 15-lead PTBDB are used to evaluate the obtained performance against the CSE tolerance limits. Our findings indicate that all but one CSE limits are satisfied. This level of performance combined with a complexity analysis, where the upper bound of the proposed algorithm, in terms of arithmetic operations, is calculated as 2:423N + 214 additions and 1:093N + 12 multiplications for N 861 or 2:553N + 102 additions and 1:093N +10 multiplications for N > 861 (N being the number of input samples), reveals that the proposed method achieves an ideal trade-off between computational complexity and performance, a key requirement in remote CVD monitoring systems
Biswas-Milovic model and its optical solitons
No full textInternational Conference on Numerical Analysis and Applied Mathematics 2018, ICNAAM 2018 -- 13 September 2018 through 18 September 2018 -- -- 149843In this work, optical solitons are obtained for the Biswas - Milovic equation as a generalized model via the extended generalizing Riccati mapping method. This method reveals several optical solitons including traveling wave solutions. The found solutions are identified with two different forms including the hyperbolic functions, the rational functions and the trigonometric functions. Reliability of our solution is given graphical consequens. © 2019 Author(s)
El proceso de creación de la película Bridge (2016): El proceso alquímico de transformarse individual y socialmente
No full textThe author and director of the film Bridge (2016), Amit R. Biswas, reflects on the process
of film-making, using strategies that deal with self (and, therefore, social) transformation
through art. In a sort of inner confession monologue, he delves not only into the more
anecdotal part of the logistics and economic tour-de-force problems that producing a film
involve; but also, and more interestingly, in the causes, nuances, and psychological details
that are contained in the plot. Seen as a process of catharsis and posterior anagnorisis, the
film unveils the subtle influences that underlie human contact, the transformation of the
human psyche by means of compassionate attitudes, and the mutual redemption suffered by
the seeming victim and his apparent saviour, in a sort of alchemic metempsychosis released
by mutual understanding and empathy.El autor y director de la película Bridge (2016), Amit R. Biswas, reflexiona sobre el proceso
de creación y producción cinematográficas, utilizando para ello estrategias que tienen que ver
con la transformación del yo (y, por ende, de la sociedad) a través del arte. En una suerte de
monólogo-confesión interior, el director profundiza no solo sobre esa parte más anecdótica
de la logística y de los enormes problemas económicos que se suscitan cuando se produce
un largometraje; lo hace también, lo que es más interesante, sobre las causas, matices y
detalles psicológicos que están contenidos en la trama. Visto el film como un proceso de
catarsis y posterior anagnórisis, se desvelan en él las sutiles influencias que subyacen en el
contacto humano, la transformación de la psique por medio de unas actitudes compasivas,
y la redención mutua que sufren la aparente víctima y el que parece su salvador, en una
metempsícosis alquímica catalizada por la comprensión y la empatía mutuas
On connections on principal bundles
No full textAbstractA new construction of a universal connection was given in Biswas, Hurtubise and Stasheff (2012). The main aim here is to explain this construction. A theorem of Atiyah and Weil says that a holomorphic vector bundle E over a compact Riemann surface admits a holomorphic connection if and only if the degree of every direct summand of E is zero. In Azad and Biswas (2002), this criterion was generalized to principal bundles on compact Riemann surfaces. This criterion for principal bundles is also explained
Data for Biswas et al., Current Biology, January 11th, 2018
No full textOriginal data sets for the paper "SMC1α substitutes for many meiotic functions of SMC1β but cannot protect telomeres from damage" by Uddipta Biswas, Michelle Stevense, and Rolf Jessberge
Entity Typing Datasets
No full textThese are the datasets used in the Entity Type Prediction task for Knowledge Graph Completion.
DB630k_Fine-grained_Hierarchical.zip dataset has been used in the papers [1] and [2]. It is an extended version of DBpedia630k dataset originally created for Text classification and is available here.
FIGER.zip dataset has also been used in the papers [1] and [2].
MultilingualETdata.zip dataset has been used in the paper [3]
NamesETdata.zip dataset has been used in the paper [4]. The CaLiGraph test dataset can also be downloaded here.
[1] Biswas R, Sofronova R, Sack H, Alam M. Cat2type: Wikipedia category embeddings for entity typing in knowledge graphs. InProceedings of the 11th on Knowledge Capture Conference 2021 Dec 2 (pp. 81-88).
[2] Biswas R, Portisch J, Paulheim H, Sack H, Alam M. Entity type prediction leveraging graph walks and entity descriptions. In The Semantic Web–ISWC 2022: 21st International Semantic Web Conference, Virtual Event, October 23–27, 2022, Proceedings 2022 Oct 16 (pp. 392-410). Cham: Springer International Publishing.
[3] Biswas R, Chen Y, Paulheim H, Sack H, Alam M. It’s All in the Name: Entity Typing Using Multilingual Language Models. In The Semantic Web: ESWC 2022 Satellite Events: Hersonissos, Crete, Greece, May 29–June 2, 2022, Proceedings 2022 Jul 20 (pp. 36-41). Cham: Springer International Publishing.
[4] Biswas R, Sofronova R, Alam M, Heist N, Paulheim H, Sack H. Do judge an entity by its name! entity typing using language models. In The Semantic Web: ESWC 2021 Satellite Events: Virtual Event, June 6–10, 2021, Revised Selected Papers 18 2021 (pp. 65-70). Springer International Publishing
El proceso de creación de la película Bridge (2016): el proceso alquímico de transformarse individual y socialmente
No full textThe author and director of the film Bridge (2016), Amit R. Biswas, reflects on the process of film-making, using strategies that deal with self (and, therefore, social) transformation through art. In a sort of inner confession monologue, he delves not only into the more anecdotal part of the logistics and economic tour-de-force problems that producing a film involve; but also, and more interestingly, in the causes, nuances, and psychological details that are contained in the plot. Seen as a process of catharsis and posterior anagnorisis, the film unveils the subtle influences that underlie human contact, the transformation of the human psyche by means of compassionate attitudes, and the mutual redemption suffered by the seeming victim and his apparent saviour, in a sort of alchemic metempsychosis released by mutual understanding and empathy.El autor y director de la película Bridge (2016), Amit R. Biswas, reflexiona sobre el proceso de creación y producción cinematográficas, utilizando para ello estrategias que tienen que ver con la transformación del yo (y, por ende, de la sociedad) a través del arte. En una suerte de monólogo-confesión interior, el director profundiza no solo sobre esa parte más anecdótica de la logística y de los enormes problemas económicos que se suscitan cuando se produce un largometraje; lo hace también, lo que es más interesante, sobre las causas, matices y detalles psicológicos que están contenidos en la trama. Visto el film como un proceso de catarsis y posterior anagnórisis, se desvelan en él las sutiles influencias que subyacen en el contacto humano, la transformación de la psique por medio de unas actitudes compasivas, y la redención mutua que sufren la aparente víctima y el que parece su salvador, en una metempsícosis alquímica catalizada por la comprensión y la empatía mutuas
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