7,293 research outputs found
Hermann Hinz (hrsgg. v.-), Germania Romana. III. Römisches Leben auf Germanischen Boden. Mit Beiträge von D. Baatz, W. C. Braat, H. Cuppers, H. Hinz, A. Rolling, W. Modrijan, M. Muller-Wllle, R. Schindler, G. T. Schwartz
No full textDe Laet Sigfried Jan. Hermann Hinz (hrsgg. v.-), Germania Romana. III. Römisches Leben auf Germanischen Boden. Mit Beiträge von D. Baatz, W. C. Braat, H. Cuppers, H. Hinz, A. Rolling, W. Modrijan, M. Muller-Wllle, R. Schindler, G. T. Schwartz. In: L'antiquité classique, Tome 40, fasc. 2, 1971. pp. 818-819
IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1
No full text: IL-1 induces its own gene expression in human PBMC, in cultured smooth muscle and in endothelial cells. IL-1-induced IL-1 may be part of a self-amplification or an autocrine growth factor in a variety of responses, and thus the endogenous regulation of IL-1 production likely contributes to the outcome of immunologic or inflammatory responses. In the present study, IFN-gamma consistently increased LPS-induced IL-1, but reduced the total amount of IL-1-induced IL-1 from PBMC. This reduction was observed in populations of adherent cells and cells selected with anti-Leu M3 antibody. On a molar basis, IFN-gamma and IFN-alpha 2 were equally effective in reducing IL-1-induced IL-1 synthesis. In PBMC of 24 human subjects, IFN-gamma also reduced PMA-induced IL-1 synthesis (67% decrease, p less than 0.001). The augmentation of LPS-stimulated IL-1 by IFN-gamma was observed only when added at the same time as LPS, but IFN-gamma could be added 6 h after stimulation with IL-1 and still suppress IL-1 production. LPS-induced mRNA for IL-1 beta was modestly enhanced by IFN-gamma whereas mRNA levels for TNF were markedly increased. In contrast, IFN-gamma suppressed mRNA accumulation for IL-beta after stimulation with IL-1 alpha by 60 to 95%. The addition of IFN-gamma 30 min before stimulation of PBMC with IL-1 suppressed IL-1 beta mRNA for up to 30 h. The half-life of IL-1 beta mRNA of approximately 2 h was not influenced by IFN-gamma. Thus, IFN-gamma reduces IL-1-induced IL-1 synthesis by suppressing IL-1-induced transcription, whereas the same concentrations of IFN-gamma augment LPS-induced IL-1 production by increasing transcription
Encapsulation of polymers into MoS2 and metal to insulator transition in metastable MoS2
No full textA general approach for the encapsulation of a variety of saturated polymers between the layers of MoS2 giving electrically conductive lamellar compounds is reported.PT: J; CR: ARMAND M, 1983, SOLID STATE IONICS, V9, P745 ARMAND M, 1990, ADV MATER, V2, P278 ARMAND MB, 1979, FAST ION TRANSPORT S, P131 BISSESSUR R, UNPUB BISSESSUR R, 1993, J CHEM SOC CHEM COMM, P687 BROMLEY RA, 1970, PHYS LETT A, V33, P242 COX SD, 1991, J PHYS CHEM-US, V95, P710 DISALVO FJ, 1975, PHYS REV B, V12, P2220 DISALVO FJ, 1990, SCIENCE, V247, P649 DIVIGALPITIYA WMR, 1989, SCIENCE, V246, P369 DIVIGALPITIYA WMR, 1991, APPL SURF SCI, V48, P572 DIVIGALPITIYA WMR, 1991, J MATER RES, V6, P1103 ENZEL P, 1989, J CHEM SOC CHEM COMM, P1326 ENZEL P, 1992, CHEM MATER, V4, P819 FLEISCHAUER PD, 1987, THIN SOLID FILMS, V154, P309 FORMSTONE CA, 1990, J CHEM SOC CHEM COMM, P501 FUKUSHIMA Y, 1987, J INCLUSION PHENOM, V5, P473 GAMBLE FR, 1970, SCIENCE, V168, P568 HUNSBERGER LR, 1990, COORDIN CHEM REV, V97, P209 INOUE H, 1987, J ELECTROANAL CH INF, V233, P291 JOENSEN P, 1986, MATER RES BULL, V21, P457 JULIEN C, 1992, MAT SCI ENG B-SOLID, V15, P73 KANATZIDIS MG, 1989, J AM CHEM SOC, V111, P4139 KANATZIDIS MG, 1993, CHEM MATER, V5, P595 MATTHEISS LF, 1973, PHYS REV B, V8, P3719 MEHROTRA V, 1990, MATER RES SOC S P, V171, P39 MURPHY DW, 1976, INORG CHEM, V15, P17 NAZAR LF, 1991, MATER RES SOC S P, V210, P417 NAZAR LF, 1992, J AM CHEM SOC, V114, P6239 OKADA A, 1985, 217396, JA, APPL OKADA A, 1987, POLYM PREPRINTS, V28, P447 OKADA A, 1990, MATER RES SOC S P, V171, P45 PEREIRA C, 1991, J PHYS CHEM-US, V95, P705 PY MA, 1983, CAN J PHYS, V61, P76 SOMA Y, 1983, CHEM PHYS LETT, V99, P153 SOMA Y, 1984, J PHYS CHEM-US, V88, P3034 TAGAYA H, 1991, CHEM LETT, V12, P2113 TRIBUTSCH H, 1980, FARADAY DISCUSS, V70, P190 VASSILIOU JK, 1990, CHEM MATER, V2, P738 WEISSER O, 1973, SULPHIDE CATALYSTS T WU CG, 1991, LOWER DIMENSIONAL SY, P427 WYPYCH F, 1992, J CHEM SOC CHEM 1001, P1386 YANG D, 1991, PHYS REV B, V43, P12053; NR: 43; TC: 63; J9: J CHEM SOC CHEM COMMUN; PG: 4; GA: MD944Source type: Electronic(1
Behavioral assessment of high-dose amphetamine withdrawal: Importance of training and testing conditions
No full textChronic d-amphetamine-treated rats were given twice daily injections at a dose of 7.5 mg/kg for 2 weeks. Acute amphetamine and saline groups of rats were given saline treatments during this time, except that for the acute group the final injection was 7.5 mg/kg d-amphetamine. Acute and chronic amphetamine groups habituated to the locomotor activity testing apparatus showed increases in both distance traveled and repetitive movement time that lasted up to 6 h following the final injection. When animals were not habituated to the activity test apparatus, however, a significant decrease in repetitive movement time was noted for the chronic amphetamine group 24-54 h following the final amphetamine injection; no differences were observed for distance traveled when the locomotor activity apparatus was novel. Swim test immobility time was assessed twice following the last injection, with the second test following the first by approximately 24 h. During the first test, decreases in immobility were observed for both chronic and acute amphetamine groups, 6-12 h following the last
injection. However, during the second test, decreases in immobility time were observed only for the chronic amphetamine groups 36-72 h following the final injection. These results indicate that 24 to 72 h after the end of the chronic amphetamine regimen a withdrawal effect was observed for both repetitive movement time in the locomotor activity test and immobility time in the swim test. The withdrawal effect was observed only for the locomotor activity groups for whom the test apparatus was novel, and only during the second test of immobility time for the swim test groups. Thus, the method of behavioral assessment can be critical for the demonstration of a high-dose amphetamine withdrawal effect
Nanoscale composites formed by encapsulation of polymers in MoS2. From conjugated polymers to plastics. Detection of metal to insulator transition
No full textPolyaniline, poly(ethylene oxide), poly(propylene glycol), poly(vinylpyrrolidinone), methyl cellulose, polyethylenimine, polyethylene, and Nylon-6, were encapsulated into MoS2. Electrical conductivity and thermoelectric power measurements of pressed pellets of (PEO)(0.92)MoS2 and (Polyaniline)(0.35)MoS2 show p-type metallic behavior. Below 14 K and 9 K respectively both show a metal to insulator transition. The thermal stability of these materials is reported.PT: J; CR: BISSESSUR R, UNPUB BISSESSUR R, 1993, IN PRESS J CHEM SOC BROMLEY RA, 1970, PHYS LETT A, V33, P242 DISALVO FJ, 1975, PHYS REV B, V12, P2220 DISALVO FJ, 1976, SURF SCI, V58, P297 DIVIGALPITIYA WMR, 1989, SCIENCE, V246, P369 DIVIGALPITIYA WMR, 1991, APPL SURF SCI, V48, P572 FUKUSHIMA Y, 1987, J INCLUSION PHENOM, V5, P473 JOENSEN P, 1986, MATER RES BULL, V21, P457 KANATZIDIS MG, 1989, J AM CHEM SOC, V111, P4139 KANATZIDIS MG, 1993, IN PRESS CHEM MATTER MATTHEISS LF, 1973, PHYS REV B, V8, P3719 MURPHY DW, 1976, INORG CHEM, V15, P17 OKADA A, 1985, 217396, JA OKADA A, 1987, POLYM PREPRINTS, V28, P447 OKADA A, 1990, MATER RES SOC S P, V171, P45 PY MA, 1983, CAN J PHYS, V61, P76 TAGAYA H, 1991, CHEM LETT, V12, P2113 WU CG, 1991, LOWER DIMENSIONAL SY, P427 YANG D, 1991, PHYS REV B, V43, P12053; NR: 20; TC: 1; J9: MOL CRYST LIQ CRYST SCI TEC A; PG: 6; GA: PV150Source type: Electronic(1
Relationship between HDL Cholesterol Efflux Capacity, Calcium Coronary Artery Content, and Antibodies against ApolipoproteinA-1 in Obese and Healthy Subjects
No full textAims: To explore the associations between cholesterol efflux capacity (CEC), coronary artery calcium (CAC) score, Framingham risk score (FRS), and antibodies against apolipoproteinA-1 (anti-apoA-1 IgG) in healthy and obese subjects (OS). Methods and Results: ABCA1-, ABCG1-, passive diffusion (PD)-CEC and anti-apoA-1 IgG were measured in sera from 34 controls and 35 OS who underwent CAC score determination by chest computed tomography. Anti-apoA-1 IgG ability to modulate CEC and macrophage cholesterol content (MCC) was tested in vitro. Controls and OS displayed similar ABCG1-, ABCA1-, PD-CEC, CAC and FRS scores. Logistic regression analyses indicated that FRS was the only significant predictor of CAC lesion. Overall, anti-apoA-1 IgG were significantly correlated with ABCA1-CEC (r = 0.48, p < 0.0001), PD-CEC (r = −0.33, p = 0.004), and the CAC score (r = 0.37, p = 0.03). ABCA1-CEC was correlated with CAC score (r = 0.47, p = 0.004) and FRS (r = 0.18, p = 0.29), while PD-CEC was inversely associated with the same parameters (CAC: r = −0.46, p = 0.006; FRS: score r = −0.40, p = 0.01). None of these associations was replicated in healthy controls or after excluding anti-apoA-1 IgG seropositive subjects. In vitro, anti-apoA-1 IgG inhibited PD-CEC (p < 0.0001), increased ABCA1-CEC (p < 0.0001), and increased MCC (p < 0.0001). Conclusions: We report a paradoxical positive association between ABCA1-CEC and the CAC score, with the latter being inversely associated with PD in OS. Corroborating our clinical observations, anti-apoA-1 IgG enhanced ABCA1 while repressing PD-CEC, leading to MCC increase in vitro. These results indicate that anti-apoA-1 IgG have the potential to interfere with CEC and macrophage lipid metabolism, and may underpin paradoxical associations between ABCA1-CEC and cardiovascular risk
A Genetic Polymorphism in the Pannexin1 Gene Predisposes for The Development of Endothelial Dysfunction with Increasing BMI
No full textEndothelial dysfunction worsens when body mass index (BMI) increases. Pannexin1 (Panx1) ATP release channels regulate endothelial function and lipid homeostasis in mice. We investigated whether the Panx1-400A>C single nucleotide polymorphism (SNP), encoding for a gain-of-function channel, associates with endothelial dysfunction in non-obese and obese individuals. Myocardial blood flow (MBF) was measured by 13N-ammonia positron emission/computed tomography at rest, during cold pressor test (CPT) or dipyridamole-induced hyperemia. Myocardial flow reserve (MFR) and endothelial function were compared in 43 non-obese (BMI < 30 kg/m2) vs. 29 obese (BMI ≥ 30 kg/m2) participants and genotyping for the Panx1-400A>C SNP was performed. Groups comprised subjects homozygous for the C allele (n = 40) vs. subjects with at least one A allele (n = 32). MBF (during CPT or hyperemia), MFR and endothelial function correlated negatively with BMI in the full cohort. BMI correlated negatively with MFR and endothelial function in non-obese Panx1-400C subjects, but not in Panx1-400A individuals nor in obese groups. BMI correlated positively with serum triglycerides, insulin or HOMA. MFR correlated negatively with these factors in non-obese Panx1-400C but not in Panx1-400A individuals. Here, we demonstrated that Panx1-400C SNP predisposes to BMI-dependent endothelial dysfunction in non-obese subjects. This effect may be masked by excessive dysregulation of metabolic factors in obese individuals
SRLx: A Personalized Learner Interface for MOOCs
No full textPast research in large-scale learning environments has found one of the most inhibiting factors to learners’ success to be their inability to effectively self-regulate their learning efforts. In traditional small-scale learning environments, personalized feedback (on progress, content, behavior, etc.) has been found to be an effective solution to this issue, but it has not yet widely been evaluated at scale. In this paper we present the Personalized SRL Support System (SRLx), an interactive widget that we designed and open-sourced to improve learners’ self-regulated learning behavior in the Massive Open Online Course platform edX. SRLx enables learners to plan their learning on a weekly basis and view real-time feedback on the realization of those plans. We deployed SRLx in a renewable energies MOOC to more than 2,900 active learners and performed an exploratory analysis on our learners’ SRL behavior.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Web Information System
Inclusion of poly(aniline) into MoO3
No full textProtonated emeraldine [poly(aniline)] has been encapsulated in MoO3 by first inserting aniline into its lattice followed by successful polymerization with (NH4)2S2O8; the new material is characterized by X-ray diffraction, IR spectroscopy, scanning electron microscopy and charge transport measurements.PT: J; CR: BEIN T, 1989, SYNTHETIC MET, V29, E163 BISSESSUR R, UNPUB DESILVESTRO J, 1990, J ELECTROCHEM SOC, V137, C5 ENZEL P, 1989, J PHYS CHEM-US, V93, P6270 GENIES EM, 1990, SYNTHETIC MET, V36, P139 INOUE H, 1987, J ELECTROANAL CH INF, V233, P291 KANATZIDIS MG, 1987, J AM CHEM SOC, V109, P3797 KANATZIDIS MG, 1989, J AM CHEM SOC, V111, P4139 KANATZIDIS MG, 1989, SOLID STATE IONICS, V32, P594 KANATZIDIS MG, 1989, SYNTHETIC MET, V28, C89 KANATZIDIS MG, 1990, CHEM MATER, V2, P222 MURPHY DW, 1979, SCIENCE, V205, P651 NAZAR LF, 1991, MATER RES SOC S P, V210, P417 NAZAR LF, 1992, J AM CHEM SOC, V114, P6239 SCHOLLHORN R, 1980, J LESS-COMMON MET, V71, P71 WHITTINGHAM MS, 1976, J ELECTROCHEM SOC, V123, P315 WU CG, 1989, POLYM MATER SCI ENG, V61, P969 WU CG, 1990, ADV MATER, V2, P364 WU CG, 1991, LOWER DIMENSIONAL SY, P427 ZUO F, 1987, PHYS REV B, V36, P3475; NR: 20; TC: 66; J9: J CHEM SOC CHEM COMMUN; PG: 3; GA: KY858Source type: Electronic(1
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