207 research outputs found
Supplemental Material, Data_Collection_Sheet - Cannabinoids for the Neuropsychiatric Symptoms of Dementia: A Systematic Review and Meta-Analysis
No full textSupplemental Material, Data_Collection_Sheet for Cannabinoids for the Neuropsychiatric Symptoms of Dementia: A Systematic Review and Meta-Analysis by Anees Bahji, Arthi Chinna Meyyappan and Emily R. Hawken in The Canadian Journal of Psychiatry</p
Growing urban anxiety and eco-dystopia in Usha K. R.'s Monkey Man
No full textVellore Institute of Technology University, Vellore, Indi
Growing urban anxiety and eco-dystopia in Usha K. R.’s Monkey Man
No full textUrban anxiety is the wretched condition people undergo due to urbanization, and they become apprehensive when thinking about a sustainable future. When a city becomes urban, some people are thrilled to explore the elevated opportunities it provides, while some fear the havoc of urbanization. The following research is based on Usha K.R.’s Monkey Man, which seeks to understand how Bangalore city witnessed a massive transformation due to urbanization from being a pensioner’s paradise to India’s renowned Silicon Valley and India’s giant IT hub. The objectives of this research are two-fold (i) to understand how urbanization makes people’s lives anxious, and (ii) to analyze how urbanization also causes environmental distress leading to eco-dystopia. Monkey Man has been the subject of urban studies, yet the notions of anxiety and dystopia are relevant today. It intends to remind the city dwellers that they can survive with minimal nature exposure but cannot live a wholesome life without it. The objectives of this research could be achieved by combining the idea of urbanization and eco-dystopia with ecocritical theory
Story Culture Framework: A Cross Cultural Study
No full textDigital storytelling has emerged as a powerful tool to engage with communities in the last few years. However, little attention has been paid for the challenges and failures faced around using digital storytelling as a tool. The paper talks about digital storytelling as a participatory method explored within three culturally different transforming communities. The key finding in the study is revealing the importance of the preliminary activities that helped design the innovative methods. In this paper the author assesses how the participatory research methods, such as story interviews, digital storytelling workshops and story kits, helped to gather participants’ personal experiences within the three chosen communities. The study proposes story culture framework a technique to explore cross cultural communities using stories as its principal focus. The author concludes by highlighting challenges for HCI researchers working with digital technologies and cross cultural communities
Research trends and network approach of critical thinking skills in English Language Teaching – A bibliometric analysis implementing R studio
No full textCritical thinking is often regarded as one of the vital skills in the 21st century. In recent years, it has become important to combine this skill with other skills such as language learning, creativity, problem-solving, decision making, and reflective thinking. As language and thoughts are intertwined and influence each other, incorporating thinking skills into English Language Teaching (ELT) can enhance academic and professional success. The prime objective of the current study is to conduct a bibliometric analysis of research on Critical Thinking (CT) in ELT from 2012 to 2022 by focusing on publication and research trends such as influential authors, globally cited documents, pertinent journals, leading countries, and significant affiliations. The current study also sheds light on the co-occurrence of keywords and thematic evolution through bibliometric analysis, examining 238 articles from Scopus and Web of Science databases using R studio (Biblioshiny). This bibliometric analysis highlights Thinking Skills and Creativity as the most pertinent journal with high citation count and China being the most cited country in this field. It also accentuates the interconnection between higher-order thinking skills, self-regulation, critical thinking, and critical reading. The thematic evolution of CT shows a shift from collaborative learning and CT (2012–2019) to language teaching and CT (2020–2022). It emphasizes the importance and the rising prominence of CT skills in language teaching. Moreover, this review will guide scholars and academicians to identify future research directions in the field of CT
Study of Serum Sclerostin Level in Chronic Kidney Disease
No full textINTRODUCTION:
Chronic kidney disease (CKD) is a major public health problem globally. Chronic Kidney Disease is defined as Glomerular Filtration Rate <60ml/min/1.73m2 for a minimum of 3 months irrespective of the cause. The CKD-mineral and bone disorder (CKD-MBD) syndrome is an important complication of kidney diseases and is present early in the evolution of CKD. Sclerostin is a secreted glycoprotein produced primarily by the osteocyte but is also expressed in other tissues, and has anti-anabolic effects on bone formation.
AIM OF THE STUDY:
To estimate the levels of Serum Sclerostin in patients with CKD and to compare them with healthy normal subjects.
MATERIALS AND METHODS:
The study was conducted at Thanjavur Medical College Hospital, Thanjavur after getting approval from the ethical committee. 50 patients of known CKD were selected as cases and 50 healthy individuals were selected as controls.Serum
Sclerostin was measured by Enzyme Immuno Assay. Blood Urea was measured by Urease-Glutamate Dehydrogenase (GLDH) Method. S.Creatinine was measured by Modified Jaffe’s method. Estimated glomerular filtration rate(eGFR) was
calculated using Modification In Diet And Renal Disease(MDRD). S.Phosphorus was measured by Ammonium Molybdate Kinetic Method.
RESULTS:
Serum Sclerostin concentrations were found to be significantly increased in patients with CKD ((55.1 ± 7.804),) when compared to the control group (mean
31.64 ±5.09). Serum Sclerostin increases as renal function declines and is inversely correlated with Creatinine clearance (r = - 0.4111). Serum creatinine and blood urea were progressively increased in cases than controls and shows positive correlation with serum S clerostin(r = 0.3720 and r = 0.3252). Serum Phosphorus was increased in cases(5.214±0.6217) and it shows positive correlation (r
=0.2095) with Serum Sclerostin.
CONCLUSION:
Serum Sclerostin is a novel biomarker in the prevention of complications such as CKD-MBD in the patients with CKD
Effect of Cold Chest Pack on Pulmonary Functions of Patients with Bronchial Asthma
No full textINTRODUCTION:
Many studies reported that the practice of Naturopathy, especially with hydrotherapy treatment, influences in improving pulmonary function. The current study was conducted to determine the effect of using Cold Chest Pack for improving pulmonary functions.
OBJECTIVE:
The intended research work aims at assessing the efficacy of Cold Chest Pack in improving the Pulmonary functions of Bronchial Asthma patients
STUDY DESIGN:
Randomized Control Trial.
METHOD:
A total of 71 study subjects belonging within the age group of 20-44 years, participated in the study. The study participants were randomized into intervention and control group. The intervention group participants will be given cold chest pack for 30 minutes for 25 days (5 days/week for 5 weeks) along with conventional medicine. Control group will be only under conventional medicine. After 5 weeks again PEFR will be recorded for both groups.
RESULT:
The study showed significant improvement in the PEFR values of the study participants. The pulmonary function observed to be significantly improved with cold chest pack among study participants.
CONCLUSION:
The practice of hydrotherapy mediated Cold Chest Pack facilitates in improving the PEFR and strengthening the pulmonary function significantly
Study of Expression of CD117 and CD34 in Phyllodes Tumor of Breast and Its Correlation with Histopathological Grade
No full textPhyllodes tumor is a mesenchymal neoplasm of breast. Accurately predicting the nature of the tumor and differentiating the different grades of phyllodes tumor often possess difficulties.
This study was conducted to assess the immunoexpression of CD 34 and CD117 in phyllodes tumor of breast and to correlate it with histopathological grade and also to evaluate the usefulness of these markers in differentiating benign from malignant phyllodes tumors.
MATERIALS AND METHODS:
This study was conducted at Coimbatore Medical College, Coimbatore. The study consists of 25 cases of phyllodes tumor of breast. Histological Grading of phyllodes tumor was done using stromal cellularity, nuclear pleomorphism, stromal overgrowth, mitotic rate, margin of tumor. In all the cases immunohistochemistry was done with markers CD34 and CD117.
Statistical correlation between stromal expression of CD34, CD117 and histopathological grade were analysed using Chi square test. p values of less than 0.05 were taken as significant.
RESULTS :
In our study most malignant PTs 4/8(50%) showed a CD34-/CD117+ immunohistochemical profile whereas most benign PTs on the other hand commonly showed the CD34+/ CD117- immunoprofile 8/11(73%).The borderline PTs commonly coexpressed both markers3/6 (50%). There was a significant association between stromal expression of CD117 and malignant phyllodes, similarly there was a significant association between stromal expression of CD34 and benign tumors. Further borderline tumors were significantly associated with stromal expression of CD117 and CD34.
CONCLUSION :
Our results suggest that these markers might be used for the diagnosing the various histopathological grades of PT
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Use of elicitor sets to characterize cellular signal transduction networks
No full textIntracellular signaling cascades can no longer be viewed as linear pathways that relay and amplify information. Often, components of different pathways interact, resulting in signaling networks. The interactions of different pathways and the dynamic modulation of the activities of the components within signaling pathways can create a multitude of biological outputs. The cell appears to use these pathways as a way of integrating multiple inputs to shape a uniquely defined output. These outputs allow the cell to respond to and adapt to an ever-changing environment. Understanding how biological systems receive, process and respond to complex data inputs has important implications for the design and utilization of sensors for a variety of applications, including toxicology, pharmacology, medical diagnostics, and environmental monitoring. This study uses the elicitor sets method, which is an experimental framework designed to monitor information flows through signal transduction pathways. The elicitor set approach has been used to derive mechanistic interpretations from the action of Phenylmethylsulfonyl Fluoride (PMSF), a serine protease inhibitor and nerve agent analog. The elicitor panel comprises of signal transduction network effectors namely forskolin, clonidine, cirazoline and H89, each of which targets the signaling pathway at known specific points. The elicitor set experiments enable compartmentalization of the cAMP signaling pathway, examining the role played by each segment and identifying possible cross-talk mechanisms. Our experiments substantiate that selection of adenyl cyclase as the reference node and 10 [mu]M forskolin as the primary elicitor, segments the upper portion of the G-Protein Coupled Receptor (GPCR) pathway associated with the G[sub q] and G[sub i] proteins. Application of the secondary elicitors, 100 nM clonidine (a2-adrenergic receptor agonist), 1 pM and 100 pM cirazoline (al-adrenergic receptor agonists), and 1 [mu]M and 100 [mu]M H-89 (PKA inhibitor) fortifies the decoupling, as the system is unresponsive to clonidine and cirazoline in the presence of forskolin, while continuing to respond to H-89. Exposure of the cells to 1 mM PMSF subsequent to forskolin addition restricted the quantifiable impact of PMSF to regions of the signaling pathways below adenyl cyclase. Triggering the system by use of secondary elicitors augmented the information resolution which is reinforced by the increased sensitivity of cells to 100 [mu]M H-89 that acts at an important checkpoint below adenyl cyclase
An overview of multidimensional factors influencing effective performance of expatriates
No full textIn the era of rapid globalization, every kind of business and commercial trading calls for a massive exchange of ideas, products, personnel, infrastructure, and development resources across the world. Today's highly competitive global business environment sets the platform for international employee assignments, wherein people possessing the required knowledge base and motivation, move across international boundaries. The purpose of the study is to identify various factors that might influence the expatriates during their foreign assignments. The study gains significance by attempting to understand the cultural challenges and intangible barriers that might exist in a new cultural setting and which might impede the performance of expatriates. The analysis is based on the review of approximately fifty existing papers. The study finally highlights the key factors that make the expatriates perform better in their new working environment
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