902 research outputs found
-ideals of compact operators
No full textsummary:We study the position of compact operators in the space of all continuous linear operators and its subspaces in terms of ideals. One of our main results states that for Banach spaces and the subspace of all compact operators is an -ideal in the space of all continuous linear operators whenever and are - and -ideals in and , respectively, with and . We also prove that the -ideal in is separably determined. Among others, our results complete and improve some well-known results on -ideals
Recommended from our members
Varsity Men's Track team, 1974
No full textFront Row- S. Silva, A. Briggs, T. Lee, R. Donle, P. Varadian, J. McKenzie, J. Webber, A. Hallquist, J. Hatch, H. Fitzgerald, J. Wnek, C. Keenan, K. Osborne, D. Nygaard; Back Row- Coach M. Norcross, C. Siegal (Mgr), M. Clorite, L. Sunderlin, J. Smith, C. Baker, D. Orenstein, K. Lutgens, E. Wiles, J. Howe, R. Pomeroy, R. Newhouse, R. Baker, D. Gibbons, P. Kane, C. Owen, T. McAloon, J. Albernaz, J. Osowski (Mgr
Recommended from our members
Varsity Men's Track team, 1973
No full textFront Row- J. Smith, W. Komm, M. Graham, J. Webber, R. Allen, A. Hallquist, J. Franson, T. Beckman, A. Murch, S. Slavick, G. Dunn, T. Ferguson, R. Stockdale, R. Donle, D. Fowler, E. Wright, S. McKenzie; Back Row- R. Mathews (Mgr), Coach Norcross, N. Wright, S. Silva, J. Hatch, C. Keenan, P. Selent, S. Yankum, J. Leather, T. Lee, K. Lutgens, A. Briggs, S. Walz, T. McAloon, P. Varadian, S. Manzi, K. Osborne, D. Nygaard, S. Fitzpatrick (Mgr
A critical review of the properties of forward and inverse problems in groundwater hydrology
No full textAccurate identification of the parameters of groundwater flow and transport model (inverse problem) is mandatory in order to obtain reliable predictions (forward problem). Unfortunately inverse problems are seldom well-posed; in this paper we review the properties of the forward and inverse problems, in order to discuss some concepts related to the uniqueness and stability of the inverse problem
Therapeutic liver repopulation by transient acetaminophen selection of gene-modified hepatocytes
No full textGene therapy by integrating vectors is promising for monogenic liver diseases, especially in children where episomal vectors remain transient. However, reaching the therapeutic threshold with genome-integrating vectors is challenging. Therefore, we developed a method to expand hepatocytes bearing therapeutic transgenes. The common fever medicine acetaminophen becomes hepatotoxic via cytochrome p450 metabolism. Lentiviral vectors with transgenes linked in cis to a Cypor shRNA were administered to neonatal mice. Hepatocytes lacking the essential cofactor of Cyp enzymes, NADPH-cytochrome p450 reductase (Cypor), were selected in vivo by acetaminophen administration, replacing up to 50% of the hepatic mass. Acetaminophen treatment of the mice resulted in over 30-fold expansion of transgene-bearing hepatocytes and achieved therapeutic thresholds in hemophilia B and phenylketonuria. We conclude that therapeutically modified hepatocytes can be selected safely and efficiently in preclinical models with a transient regimen of moderately hepatotoxic acetaminophen
Spatial mobility and social outcomes
No full textThe research reported in this paper was made possible through the financial support of the Marie Curie programme under the European Union's Seventh Framework Programme (FP/2007-2013) / Career Integration Grant n. PCIG10-GA-2011-303728 (CIG Grant NBHCHOICE, Neighbourhood choice, neighbourhood sorting, and neighbourhood effects). The authors also acknowledge the UK Economic and Social Research Council (ESRC RES-074-27-0020).This paper examines the nature and extent of socio-spatial mobility in Great Britain. In contrast with previous studies, we investigate the entire spectrum of moves within and across the hierarchical structure of neighbourhoods. We use data from the British Household Panel Survey to trace moves between neighbourhoods defined using the Indices of Multiple Deprivation. We define upward socio-spatial mobility as moving to neighbourhoods with greater levels of advantage (lower levels of deprivation), and downward socio-spatial mobility as the shift to less advantaged neighbourhoods. As expected, the results show that there are strong associations between origin and destination neighbourhood types. We find that education and income play critical roles in the ability of individuals to make neighbourhood gains when they move. An important finding of the research is the way in which the housing market structurally conditions socio-spatial mobility. In the UK and probably more broadly, the opportunity to move to socially advantaged places is highly stratified by housing tenure.Peer reviewe
Foryngelse for et bærekraftig skogbruk
No full textDet strategiske instituttprogrammet om etablering av skog «Foryngelse for et bærekraftig skogbruk» (Nyskog) har fokusert på foryngelse i ulike former for lukkede hogster i sjiktet skog, på plantetyper og plantekvalitet med spesiell vekt på virkninger av kortdagsbehandling. Forskningen har også gått inn på biologisk bekjempelse av gransnutebiller med nematoder. Undersøkelsene omfatter videre ulike typer markberedning og utvikling av utstyr for skånsom markberedning. Forsøkene har vært gjort i gran- og furuskog, og i kontrollerte klimakammer. På bakgrunn av resultatkontrollen for skog og miljø samt skogstatistikk fra Statistisk sentralbyrå framgår det at tilplantet areal er kraftig redusert i løpet av de siste 10 åra samt at totalt antall omsatte planter er mer enn halvert. Mens plantearealet er redusert har arealet som forynges naturlig økt. Store deler av dette arealet er ikke tilrettelagt for foryngelse, og markberedning kunne vært brukt i langt større grad...Foryngelse for et bærekraftig skogbrukpublishedVersio
Explaining 'Inertia' in R&D internationalisation: Norwegian firms and the role of home country-effects
No full textWe ask why firms from certain countries show a higher propensity to centralise their R&D activities athome than firms from other countries, using the example of Norway. We highlight that it is the interplaybetween the industrial structure and political and economic orientation of the home economy that plays animportant role in how firms engage in both home and overseas activities, including R&D. In general, nationalsystems of innovation (NSI) and industrial and technological specialisation of countries changes only verygradually, and – especially in newer, rapidly evolving sectors - much more slowly than the technological needsof firms. Thus, firms must either import and acquire the technology they need from abroad, or venture abroadand seek to internalise aspects of other countries’ NSI. In the case of Norway, two groups of firms exist. The firstgroup are large firms in traditional sectors, that are highly embedded, and around whom the Norwegian NSI hasbeen built, and which have a low level of R&D internationalisation. The second group of firms are SMEs inscience based sectors who are (slowly) expanding R&D abroad to seek competences in technologies notavailable domestically. The low R&D internationalisation of both groups reflects their embeddedness in thedomestic NSI, which has acted as a powerful centripetal force, creating a technological and organisationalinertia.research and development ;
Structural Modeling and Electron Paramagnetic Resonance Spectroscopy of the Human Na+/H+ Exchanger Isoform 1, NHE1
No full textWe previously presented evidence that transmembrane domain (TM) IV and TM X-XI are important for inhibitor binding and ion transport by the human Na+/H+ exchanger, hNHE1 (Pedersen, S. F., King, S. A., Nygaard, E. B., Rigor, R. R., and Cala, P. M. (2007) J. Biol. Chem. 282, 19716-19727). Here, we present a structural model of the transmembrane part of hNHE1 that further supports this conclusion. The hNHE1 model was based on the crystal structure of the Escherichia coli Na+/H+ antiporter, NhaA, and previous cysteine scanning accessibility studies of hNHE1 and was validated by EPR spectroscopy of spin labels in TM IV and TM XI, as well as by functional analysis of hNHE1 mutants. Removal of all endogenous cysteines in hNHE1, introduction of the mutations A173C (TM IV) and/or I461C (TM XI), and expression of the constructs in mammalian cells resulted in functional hNHE1 proteins. The distance between these spin labels was similar to 15 A, confirming that TM IV and TM XI are in close proximity. This distance was decreased both at pH 5.1 and in the presence of the NHE1 inhibitor cariporide. A similar TM IV.TM XI distance and a similar change upon a pH shift were found for the cariporide-insensitive Pleuronectes americanus (pa) NHE1; however, in paNHE1, cariporide had no effect on TM IV.TM XI distance. The central role of the TM IV.TM XI arrangement was confirmed by the partial loss of function upon mutation of Arg(425), which the model predicts stabilizes this arrangement. The data are consistent with a role for TM IV and TM XI rearrangements coincident with ion translocation and inhibitor binding by hNHE1
Spaces of contestation: the everyday experiences of ten African migrants in Cape Town
No full textIncludes bibliographical references.Xenophobia in South Africa is so overt that it has take a covert form. The 'xenocide' events that took place in 2008 were called xenophobic acts. It is the recurrent denialism of xenophobia on an everyday basis that this project has explored through the narrative accounts of ten African migrants in Cape Town. The lived everyday experiences of ten African migrants have brought forward the central argument of this thesis. From the data, it is evident that as a reponse to everyday pressures of prejudices and xenophobia in social and physical spaces, African migrants have developed mutable, unsettled and vagrant identities in order to cope with everyday low level violence. This argument emerged as four key stressors have been identified as the components of a more substantial explanation of xenophobia in South Africa. The four key components are: the enforcement of identity (national and group), the demarcation of spaces of belonging, the experiences of economic insecurity, and lastly a 'culture of violence' in South Africa. This thesis argues that these four stressors are the result of an on-going active process of xenophobic attitudes
- …
