642 research outputs found
Linaria officinarum, Basilico, Sisaro
No full text1. Nome scientifico: Linaria vulgaris Miller
(Scrophulariaceae)
Nome attuale: Linaiola
2. Nome scientifico: Ocimum basilicum L.
(Lamiaceae, Labiatae)
Nome attuale: Basilico
3. Nome scientifico: Sium sisarum L.
(Apiaceae, Umbelliferae)
Nome attuale: Sisaro, Sedanin
Antiprotozoal activity of novel diaryliminophenazines
No full textRecently, we synthesized a set of novel iminofenazines bearing a bicyclic basic head linked through an alkyl chain to the imino nitrogen in position 3 on the phenazine nucleus (Fig.1).
Most of these compounds inhibited the growth of different species of Leishmania promastigotes as well as of chloroquine sensitive (CQ-S) and chloroquine resistant (CQ-R) strains of P. falciparum with IC50 in the submicromolar range. Unfortunately, these compounds exhibited also a significant toxicity against the human endothelial cell line HMEC-1 with IC50 in the low micromolar range and with a consequent low selectivity index.
Figure1.Structures of the previously synthesized compounds.
To continue the studies on the antiprotozoal potentialities of this class of compounds and with the aim to improve their activity and selectivity on protozoa, we have now synthesized novel compounds characterized by the replacement of the aniline moiety in pos. 2 of the phenazine nucleus with an aminopyridine, and/or by a quaternarization of the basic nitrogen in the side chain with a methyl group (Fig.2).
Figure 2. Structures of the new compounds synthesized.
The in vitro activity of the new compounds on Leishmania promastigotes and on CQ-S and CQ-R strains of P. falciparum, as well as on the HMEC-1 cell line will be presented and discussed.
References
[1] A. Barteselli, M. Gavazzi, N. Basilico, S. Parapini, D. Taramelli, A. Sparatore. Clofazimine analogs with antileishmanial and antimalarial activities. XXII National Meeting on Medicinal Chemistry, Roma 2013
Archeologia del rifugio antiaereo: utilizzo di opere ipogee antiche e moderne per la protezione dei civili
No full textIA nelle piattaforme di e-Health ed e-Welfare
No full textLe piattaforme di e-Health e e-Welfare stanno au-mentando via via la varietà e qualità dei loro servi-zi. Elemento chiave del loro successo è un motore di IA che valuta le prestazioni dell’utente e perso-nalizza l’intervento. Descriviamo qui due piatta-forme di questo tipo sviluppate all’interno di pro-getti di R&D finanziati dalla Comunità Europea
Malaria diagnosis, therapy, vaccines, and vector control
No full textMalaria remains a massive public health problem in the world affecting more than 200 million people and causing 600,000 deaths every year, mostly in children under 5 years of age. Malaria control strategies include treatment of diagnosis-confirmed patients with artemisinin-based combination therapy, protection of individuals with insecticide-treated bed nets, and indoor residual spraying to fight against the vector. However, the emergence of artemisinin resistance in P. falciparum in Southeast Asia and the development of insecticide resistance in mosquitoes are putting these control tools at risk. An effective vaccine could be the tool to reach the eradication goal. However, only the RTS,S/AS01 vaccine is likely to be launched in 2015, despite its effectiveness is modest
Simple posterior elbow dislocations: Conservative management and role of ulnar-bone coverage angle
No full textBACKGROUND: In simple posterior elbow dislocations, not associated with fracture, conservative treatment consists of a closed reduction with the restoration of joint relationships and a subsequent immobilization in a cast in the absence of any postreduction instability. The functional outcome is usually satisfactory, but several complications are possible. The aim of this study was to determine the outcomes of simple elbow dislocation treated conservatively and the possible role of an open ulnar bone converge angle (UBCA) as a risk factor. METHODS: A retrospective case series study with a follow-up of 60.96 months (range, 24-95) was performed, analyzing simple elbow dislocation cases, treated at Unit of Orthopedics and Trauma, Varese, Italy, from October 2012 to September 2018. The population consisted of 28 patients, 17 men and 11 women, with an average age of 53 (range, 26-90). A conservative treatment, consisting in closed reduction and immobilization in plaster cast, was applied if there was no instability after reduction. The Disability of the Arm, Shoulder and Hand (DASH), the Mayo Elbow Performance Score (MEPS) questionnaires were used. CT-scan were analyzed to calculate the UBCA. RESULTS: At the last follow-up there was a reduction of the affected elbow ROM compared to the contralateral: 52.6% of patients had an extension deficit, 15.9% of flexion, 10.6% of prone supination. Under no circumstances was post-traumatic residual instability. A statistically significant reduction was found for extension of the affected elbow (-3.05° vs. 3.26°) and for the entire flexion-extension motion (134.05° vs. 142.27°) compared to the healthy one. The average DASH score is 6.029 and the MAYO average score is 94.286, values considered excellent. The average UBCA was 171.59° (range, 147.50°-191.50°). In 3 patients (15.8%) prone-supination pain was reported, and of these 2 also to flexion-extension (10.5%). CONCLUSIONS: The outcome of posterior elbow simple dislocations, conservatively treated, was satisfactory. A UBCA, narrower than 180°, may represent a risk factor for dislocation
Modified quaternary ammonium salts as potential antimalarial agents
No full textA series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well. All compounds were screened against chloroquine resistant W-2 (CQ-R) and chloroquine sensitive, D-10 (CQ-S) strains of Plasmodium falciparum showing IC50 in the submicromolar range and low toxicity against human endothelial cells
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