171,079 research outputs found
The charge Australians made [music] /
No full textFor voice and piano.; Lyrics printed as text printed inside front cover: The charge Australians made.; Also available online http://nla.gov.au/nla.mus-vn4762813; Also available in an electronic version via the Internet at: http://www.samemory.sa.gov.au/site/page.cfm?c=563
The charge Australians made [music] : song /
No full textCover title.; For voice and piano.; Text of song printed inside front cover. Printed inside back cover is portion of another song, The small still voice.; "Copyright 4413".; Also available online http://nla.gov.au/nla.mus-vn2863777; MUS: N, MUSM 135197 ; A, AO3367
Quin-C1: a selective Fpr2 agonist that shifts microglial phenotype following LPS and Aβ1-42 exposure
No full textOxidative stress and inflammation are both central contributors to Alzheimer’s disease (AD) pathology [1,2]. Microglia, the resident immune cells of the brain and spinal cord, are primary contributors the chronic oxidative and inflammatory brain environment seen in AD. Through their persistent and inappropriate activation, they consequentially contribute to neuronal damage [3]. Dampening this microglial state may provide neurons protection from this ever increasing chronic environment and is thus a potential therapeutic strategy for AD. Formyl peptide receptor 2 (Fpr2) is known to play a key role in peripheral inflammation resolution [4,5], and is expressed in microglia [6]. We have hypothesised that activation of this receptor with the agonist Quin-C1 can reduce both LPS and Aβ1-42 induced reactive oxygen species (ROS), and promote a pro-resolving microglial phenotype.
Immortalised murine microglia (BV2 cells) were stimulated with LPS (50ng/ml) for 1h prior to treatment with 100nM Quin-C1. Cytokine (TNFα and IL-10) and nitric oxide (NO) production was detected at 24 and 48h. ROS were monitored with carboxy-H2DCFDA. LPS (50ng/ml) or Aβ1-42 (100nM) was administered for 10 minutes prior to Quin-C1 (100nM). ROS production was detected every 5 minutes for up to 2h. Primary murine microglia were treated with Aβ1-42 for 24h prior to Quin-C1. Expression of CD38 and CD206 were detected by flow cytometry 48h post-Aβ1-42 administration.
Quin-C1 significantly suppressed LPS-induced production of TNFα and NO at both 24 and 48h. Further, Quin-C1 significantly enhanced the production of IL-10 48h post-exposure. Strikingly, Quin-C1 reduced LPS and Aβ1-42-induced ROS production back to baseline levels. This was then blocked when the Fpr2 antagonist, WRW4 (10μM), was added 5 minutes prior to Quin-C1. Finally, Quin-C1 successfully increased CD206 and reduced CD38 expression in primary murine microglia, following Aβ1-42 exposure.
Together, these data highlight selective targeting of Fpr2 as a potential therapeutic target to dampen oxidative stress and neuroinflammation in AD.
1. Heneka et al. (2015). Lancet Neurol 14: 388-405.
2. Kamat et al. (2016). Mol Neurobiol 53: 648-661.
3. Cunningham C (2013). Glia 61: 71-90.
4. Vital et al. (2016). Circulation 133: 2169-79.
5. McArthur et al. (2015). J Immunol 195: 1139-51.
6. Zhu et al. (2015). J Alzheimers Dis 43: 1237-50
Quin C., Boniface J., Gaussel A., Les consommateurs.
No full textCoornaert M. Quin C., Boniface J., Gaussel A., Les consommateurs.. In: Revue française de sociologie, 1967, 8-1. p. 109
Loss of quin 2 accompanies degranulation of mast cells
No full textAbstractStimulation of quin 2 loaded mast cells in the presence of 1 mM extracellular calcium produced a rapid and sustained increase in quin 2 fluorescence. This was accompanied by degranulation and the release of histamine. When Ca was replaced by EGTA or when Mn was present, a decrease in fluorescence accompanied degranulation. The increase in quin 2 fluorescence accompanying stimulation of mast cells appears to be due to the interaction of extracellular Ca with quin 2 associated with the secretory granule matrix released upon exocytosis
Modélisation séculaire du marché des transports de marchandises. (Modèle « S.D. FRET »)
No full textCet article propose une modélisation du trafic de marchandises pour la France, qui couvre une période de cent cinquante ans (1841-1994). Trois résultats ressortent de cette étude cliométrique. Tout d'abord, l'élasticité du trafic total par rapport à la production industrielle chute après la première guerre mondiale. Ensuite, les performances des différents modes de transport (route, voie ferrée, voie d'eau) en termes de prix et d'offre déterminent les parts de marché dans le long terme. Enfin, nous échouons à mettre en évidence un impact de la pression du trafic de chaque mode sur le développement du réseau concerné.Modélisation du trafic de marchandises ; cliométrie ; modèle séculaire « SD Fret » ; modèle prix-temps ; France
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The striatal lesion induced by QUIN in rats.
No full text<p>In the left panel, a schematic representation of the lesion site (dorsal striatum) in a drawing of a coronal section of the rat brain is depicted. Red line represents the needle trajectory. In the right panel, <b>A-D</b> micrographs (40X) show striatal sections stained with Haemotoxylin & Eosin (Bar size 100 μm), where <b>A</b> corresponds to Sham (mechanically lesioned right striatum); <b>B</b> is the contralateral (unlesioned) striatum in the same animal; <b>C</b> shows the right striatum lesioned by QUIN (240 nmol/μl); and <b>D</b> depicts the contralateral unlesioned striatum from the same QUIN-infused rat. Sham and unlesioned striata (<b>A</b>, <b>B</b> and <b>D</b>) show neuronal cells without structural alterations, whereas the QUIN-lesioned striatum (<b>C</b>) exhibits morphological alterations nearby the lesion site that were characterized by diffuse vacuolization, pyknosis, edema and neuropil degeneration.</p
QUIN 2.0 - new release of the QUaternary fault strain INdicators database from the Southern Apennines of Italy
No full text: QUIN database integrates and organizes structural-geological information from published and unpublished sources to constrain deformation in seismotectonic studies. The initial release, QUIN1.0, comprised 3,339 Fault Striation Pairs, mapped on 445 sites exposed along the Quaternary faults of central Italy. The present Data Descriptor introduces the QUIN 2.0 release, which includes 4,297 Fault Striation Pairs on 738 Structural Sites from southern Italy. The newly investigated faults span ~500 km along the Apennines chain, with strikes transitioning from ~SE to ~SW and comprehensively details Fault Striation Pairs' location, attitude, kinematics, and deformation axes. Additionally, it offers a shapefile of the fault traces hosting the data. The QUIN 2.0 release offers a significant geographic extension to the QUIN 1.0, with comprehensive description of local geometric-kinematic complexities of the regional pattern. The QUIN data may be especially relevant for constraining intra-Apennine potential seismogenic deformation patterns, where earthquake data only offer scattered or incomplete information. QUIN's data will support studies aimed at enhancing geological understanding, hazard assessment and comprehension of fault rupture propagation and barriers
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
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