4,221 research outputs found
Recommended from our members
Daughter of fortune: Isabel Allende's popularity from a readership perspective
No full textThe primary aim of this thesis is to explore and critically interrogate Isabel Allende’s popularity cross-culturally in Britain and Spain. It analyses readers’ responses to Allende’s works as well as the discourses surrounding her public representation, an approach that is ‘readerly’ but must also take account of production and text. This approach is intended to further the understanding of Allende’s work which so far has always been analysed from a textual perspective. However, the relationship between Allende’s popularity, her texts, public representation and readers has not been yet analysed in detail.This thesis is innovative in other ways too. Methodologically, it approaches readers through the under studied cultural form of the reading group. It also incorporates a comparative dimension by looking at the reception of Allende in two different cultural contexts: the British and Spanish respectively. Finding out about Allende’s popularity has involved asking readers about their reading experiences as well as analysing the production of discourses around her public representation. Paul Ricoeur’s (1984, 1988) perspective on authorial intentions and readers’ responses to texts helps in understanding the intricacies surrounding what is involved in reading any text. It draws attention to Allende’s and her publishers’ authorial strategies, her ‘strategies of persuasion’ and the specificity of the lives and contexts of British and Spanish reading publics. Equally, this ‘readerly’ approach draws on feminist audience research and primarily on the work of Ien Ang and Janice Radway. Their work with viewers and readers respectively is particularly useful in establishing and developing methodological parameters for the study of reading groups. As a whole, this thesis contributes to the understanding of Allende’s cross-cultural popularity by situating readers at the centre
Encapsulation of indicaxanthin-rich Opuntia green extracts by double emulsions for improved stability and bioaccessibility
No full textThis article belongs to the Special Issue Encapsulation Processes: Valorization, Stabilization and Commercialization of Active and Natural Compounds.Opuntia ficus-indica var. Colorada fruit is an important source of indicaxanthin, a betalain with antioxidant, anti-inflammatory, and neuromodulatory potential, proven in both in vitro and in vivo models. Other betalains and phenolic compounds with bioactive activities have also been identified in Colorada fruit extracts. These compounds may degrade by their exposure to different environmental factors, so in the present research, two double emulsion systems (W1/O/W2) were elaborated using Tween 20 (TW) and sodium caseinate (SC) as surfactants to encapsulate Colorada fruit pulp extracts, with the aim of enhancing their stability during storage. Encapsulation efficiencies of up to 97.3 ± 2.7%, particle sizes between 236 ± 4 and 3373 ± 64 nm, and zeta potential values of up to ∣46.2∣ ± 0.3 mV were obtained. In addition, the evaluation of the in vitro gastro-intestinal stability and bioaccessibility of the main individual bioactives was carried out by standardized INFOGEST© protocol, obtaining the highest values for the encapsulated extract bioactives in comparison with the non-encapsulated extract (control). Especially, TW double emulsion showed bioaccessibility values of up to 82.8 ± 1.5% for the main bioactives (indicaxanthin, piscidic acid, and isorhamnetin glucoxyl-rhamnosyl-pentoside 2 (IG2)), indicating a promising potential for its use as a functional natural colorant ingredient.This research was funded by PID2020-118300RB-C21 from MCIN/AEI/10.13039/501100011033 and “ERDF A way of making Europe”.Peer reviewe
A Discussion About Writing Fiction and Creative Prose with Isabel Huggan
No full textAward-winning Canadian author Isabel Huggan talks to students about writing, with a focus on fiction and creative non-fiction.Presentation for English 2905 (Introduction to Creative Writing), taught by Dr. Stepanie McKenzie
Humanismo y Reforma en la corte renacentista de Isabel de Vilamarí : Escipión Capece y sus lectoras
No full textDurante la primera mitad del siglo XVI y en la corte salernitana del último príncipe de la casa Sanseverino y de su esposa, Isabel de Vilamarí (noble señora de origen catalán) se desarrolló un intenso clima intelectual. Allí se congregaron artistas y humanistas italianos y españoles. En este ambiente de intercambio cultural, atento en participar en las ideas de la Reforma que se difundió en Nápoles gracias a B. Ochino y a Valdés, nace el poema De principiis rerum del último académico pontaniano: Escipión Capece. En esta obra no sólo se rastrean motivos lucrecianos y virgilianos sino también el influjo de los tratados cosmológicos de Pontano. En este estudio, la autora propone el análisis de la figura y de la obra de Capece a través de sus lectoras: Isabel de Vilamarí y las mujeres cultas de su corte.During the first half of sixteenth century and in the Salernitan court of the last prince Sanseverino and his wife Isabel de Vilamarí (a lady coming from a noble Catalan family) an intense intellectual climate developed. Italian and Spanish artists and humanists met there. In this environment of cultural exchange, that shared in the Reform ideas divulged in Naples by B. Ochino and Valdés, Scipione Capece (the last member of the Pontanian Academy) writes his poem De principiis rerum. In his book Capece uses Latin literature (Vergil and Lucretius mainly) and Pontano's treatises on cosmology. The author of this paper studies Scipione Capece through his female readership: Isabel de Vilamarí and the learned women from her court
Humanismo y Reforma en la corte renacentista de Isabel de Vilamarí : Escipión Capece y sus lectoras
No full textDurante la primera mitad del siglo XVI y en la corte salernitana del último príncipe de la casa Sanseverino y de su esposa, Isabel de Vilamarí (noble señora de origen catalán) se desarrolló un intenso clima intelectual. Allí se congregaron artistas y humanistas italianos y españoles. En este ambiente de intercambio cultural, atento en participar en las ideas de la Reforma que se difundió en Nápoles gracias a B. Ochino y a Valdés, nace el poema De principiis rerum del último académico pontaniano: Escipión Capece. En esta obra no sólo se rastrean motivos lucrecianos y virgilianos sino también el influjo de los tratados cosmológicos de Pontano. En este estudio, la autora propone el análisis de la figura y de la obra de Capece a través de sus lectoras: Isabel de Vilamarí y las mujeres cultas de su corte.During the first half of sixteenth century and in the Salernitan court of the last prince Sanseverino and his wife Isabel de Vilamarí (a lady coming from a noble Catalan family) an intense intellectual climate developed. Italian and Spanish artists and humanists met there. In this environment of cultural exchange, that shared in the Reform ideas divulged in Naples by B. Ochino and Valdés, Scipione Capece (the last member of the Pontanian Academy) writes his poem De principiis rerum. In his book Capece uses Latin literature (Vergil and Lucretius mainly) and Pontano's treatises on cosmology. The author of this paper studies Scipione Capece through his female readership: Isabel de Vilamarí and the learned women from her court
Isabel Allende recuerdos para un cuento = Isabel Allende : memories for a story
No full textA simple description of the childhood and youth of the Chilean author Isabel Allend
El Tlacuache Núm. 144 (2004). 144 Año 4 (2004) octubre. El Tlacuache
No full text-De cantares, refranes, cementerios y epitafios por Isabel Garza Gómez. - El Yauhtli por Margarita Avilés y Macrina Fuentes. - De ofrendas y cosechas por Isabel Garza Gómez
Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease
No full textAlzheimer’s disease still represents an untreated multifaceted pathology, and drugs able to stop or reverse its progression are urgently needed. In this paper, a series of naturally inspired chalcone-based derivatives was designed as structural simplification of our previously reported benzofuran lead compound, aiming at targeting both acetyl (AChE)- and butyryl (BuChE) cholinesterases that, despite having been studied for years, still deserve considerable attention. In addition, the new compounds could also modulate different pathways involved in disease progression, due to the peculiar trans-α,β-unsaturated ketone in the chalcone framework. All molecules presented in this study were evaluated for cholinesterase inhibition on the human enzymes and for antioxidant and neuroprotective activities on a SH-SY5Y cell line. The results proved that almost all the new compounds were low micromolar inhibitors, showing different selectivity depending on the appended substituent; some of them were also effective antioxidant and neuroprotective agents. In particular, compound 4, endowed with dual AChE/BuChE inhibitory activity, was able to decrease ROS formation and increase GSH levels, resulting in enhanced antioxidant endogenous defense. Moreover, this compound also proved to counteract the neurotoxicity elicited by Aβ1–42 oligomers, showing a promising neuroprotective potential
5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5 H -indolo[2,3- b] quinolin-11-amine: a highly potent human cholinesterase inhibitor
No full textThe synthesis, cholinesterase inhibition, molecular modelling and ADME properties of novel tacrine-neocryptolepine heterodimers are described. Compound 3 [5-methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine], showing a moderate inhibition of the AÎ21-42self-aggregation (26.5% at a 1:5 ratio with AÎ21-42), and a calculated logBB value (0.27) indicating excellent potential BBB penetration, is a highly potent human cholinesterase inhibitor [IC50(hAChE) = 0.95 ± 0.04 nM; IC50(hBuChE) = 2.29 ± 0.14 nM] which can be listed among the most potent hAChE inhibitors so far identified, and is not hepatotoxic in vitro at the concentrations at which the ChEs are inhibited. A molecular modeling study was also undertaken in order to elucidate the AChE and the BuChE bind modes of all the new compounds. The docking results show that all of them bind to AChE in extended conformations and to BuChE in folded conformations. Moreover, these studies revealed that the length of the linker is crucial to binding both the catalytic anionic site and the peripheral anionic site
Author Correction: the BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds
No full textIn this article the author name Maria Isabel Behrens was incorrectly written as Maria Isabel Beherens. The original article has been corrected.Versión Publicad
- …
