1,721,558 research outputs found
Malattia di Castleman multicentrica associata a sarcoma di Kaposi Savoia P, Fierro MT, Quaglino P, Zaccagna A, Bernengo MG
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"Spiky/keratosis-pilaris-like early follicular mycosis fungoides: a clinicopathologic study of 20 cases with extended follow-up
No full textBackgrounds: Follicular mycosis fungoides is a distinct form of T-cell lymphoma whose course is considered aggressive.
Methods: a retrospective study with long-term follow-up of 20 patients diagnosed with spiky/keratosis-pilaris-like follicular mycosis fungoides
between 2008 and 2017 was conducted.
Results: 12 males and 8 females were identified, with a mean age at first diagnosis of 59 years (range 42-86). Hyperkeratotic follicular papules
were the sole clinical finding in 16/20 patients. A diagnostic delay between first symptom development and initial diagnosis was frequent
(mean 42 months). The head/neck region was concurrently affected only in 2 patients. Disease stage at diagnosis was IA in 2 patients (10%) and
IB in 18 (90%). Five patients had almost complete lesion regression, whilst there was only a slight improvement, without regression in 14.
Two patients developed infiltrated papules, comedones and small cysts during follow-up. Only 1 patient progressed to tumor stage (IIB) 5 years
after first diagnosis. The mean follow-up was 7 years (range: 12-180 months). None of them died of cutaneous lymphoma.
Conclusions: FMF presenting with only spiky/keratosis-pilaris-like lesions have an excellent prognosis at medium term follow-up. Early recognition
of patients with this peculiar FMF presentation might lead to identify prognostic factors
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Multiple primary melanomas: analysis of 49 cases.
No full textDevelopment of multiple primary melanomas is a rare but well recognized disease, with an estimated incidence ranging from 1.75% to 8.5% in several series. The clinical, histological and epidemiological characteristics of 49 patients, identified from 2470 with histologically confirmed melanoma, are described in this study. Thirty-five of these patients had two primary melanomas, 11 had three melanomas and three had four, five and six melanomas, respectively. Diagnosis was concurrent in 22 patients (45%); in the remaining cases the median time interval between the first and second melanoma was 22.6 months and the longest interval was 21.5 years. The mean Breslow's thickness decreased significantly (P < 0.001) from the first melanoma to the second and third lesion. The multiple melanoma patients had a higher percentage of subjects over 70 years of age or with lentigo maligna melanoma than single melanoma patients. The mean follow-up time was 12 years (range 4 23 years). The 5-year survival rate from first melanoma excision (83%) does not differ from that of patients with a single melanoma. In conclusion, the presence of multiple primary melanomas does not appear to be a negative prognostic factor; our data show the importance of close follow-up in melanoma patients in order to detect not only metastases, but also subsequent primaries in their earliest phases
Malattia di Destombes-Rosai-Dorfman ad esclusivo interessamento cutaneo: studio istologico, immunoistochimico ed ultrastrutturale di un caso.
No full textA project by the SIDeMaST Immunopathology Group on cutaneous vasculitis
No full textVasculitides are a challenge to the clinician, in terms of both diagnosis and therapy. Multiple classification systems have been implemented and the numerous classification schemes reflect the complexity of establishing a simple classification that could be functional for daily care. Although vasculitis classification has become increasingly elaborated, some areas remain ill defined. Some forms of vasculitis are still difficult to assign to a specific disease entity. Generally accepted operational criteria are available for many vasculitides, but for some entities there are no effective criteria. Moreover, diagnostic criteria for vasculitis with sufficient strength and/or confidence that can be universally accepted are not yet available. The need for diagnostic criteria validated and agreed upon is particularly relevant in the context of cutaneous vasculitis. The project of the SIDeMaST Italian Group of Immunopathology on cutaneous vasculitis is a national prospective observational study designed to develop and validate diagnostic criteria and to improve and validate classification criteria for cutaneous small vessel vasculitis also known as leukocytoclastic vasculitis (CLV). Primary objective of the study will also be that of developing the CUtaneous VAsculitis Severity Index (CUVASI). Secondary objectives of the project will be: 1) definition of the etiological agents that are most frequently associated with CLV; 2) search for possible correlations between causative agent and peculiar clinical and/or histopathological aspects; 3) evaluation of immunofluorescence pattern observed in this specific group of primitive cutaneous vasculitis in order to characterize the diagnostic sensitivity and specificity of this technique; 4) identification of a set of clinical investigations and laboratory tests to be performed for a correct CLV assessment. Actually 15 Italian dermatological clinics are contributing to the project and anticipated recruiting >100 patients with CLV. A pilot retrospective study to assess the feasibility of the project is going to be launched and if its results are positive then the prospective study will be started and it promises to be a unique opportunity to evaluate a large database on CLV in Italian population
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