1,721,784 research outputs found

    Anti-diabetic treatment and cancer occurrence among patients with type II diabetes mellitus

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    This is a retrospective cohort study, with nested case-control analyses, of type II diabetes patients, to evaluate the association between anti-diabetic treatment and cancer incidence. Methods: Patients who were initially stabilized on an oral hypoglycemic agent (OHA) mono-therapy, including metformin, sulfonylurea, TZD, and meglitinides, in the GPRD were included in the cohort. New diagnoses of cancer during cohort follow up were compared among exposure groups. In addition to the cohort analyses, solid tumors, as well as breast cancer and colorectal cancer, identified during the cohort follow-up were matched to controls and case-control analyses were performed within the cohort. Results: Compared to metformin, there was no difference in risk of malignant solid tumors or hematological malignancy with other major classes of OHAs in the cohort. The case-control analyses further supported the findings that these OHA classes or their combinations did not alter the risk of malignant solid tumors. iii In the case-control analyses, exposure to insulin was associated with a 64% (95% CI: 1.24, 2.16) higher risk of malignant solid tumors and this risk was modified when combined with different OHAs. When sulfonylurea was added to insulin, the risk of cancer was increased to almost 3 times (OR = 2.75, 95% CI: 1.51, 5.03), while adding metformin to insulin changed the odds ratio to 1.35 (95% CI: 0.94, 1.94). Similar results were found for breast cancer in which insulin was associated with a significant increase of more than 2 times in risk and other OHAs without insulin were not related to altered risk. For colorectal cancer (CRC), both sulfonylurea and TZD were associated with around a 2-fold significant risk increase compared to metformin. The odds of developing CRC were also elevated after starting insulin (OR = 1.41), although this did not reach statistical significance in these data. Conclusion: This study provides evidence that neither sulfonylurea nor TZD substantially alter the risk of solid tumor compared to metformin among type II diabetes patients. Insulin is associated with higher risk of cancer and this risk may be diminished by concomitant use of metformin, but appears to be magnified by concomitant use of sulfonylurea.Ph. D.Includes bibliographical referencesby Hong Qi

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Design and Analysis of Metal Thin-Film Ignition Chip

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    隨著微機電製程技術的成熟,運用製程技術製作電點火晶片取代傳統爆炸電橋絲,具有發火能量小、反應時間短、電橋爆炸溫度高等優點。這類固態點火晶片可應用在啟動汽車安全氣囊、點燃飛彈火箭系統、引爆鈍感主裝炸藥與燃料推進等方面,提供一種更為可靠的機制。運用於軍事用途時,電點火電橋晶片安裝在具有點火藥鋯粉之引燃器上,並須通過低發火能、低反應時間、抗靜電放電、抗電磁干擾等軍規測試。 在以半導體製程研製晶片電橋方面,使用到微影、薄膜沉積與光阻掀舉等製程來製作金屬薄膜之電點火晶片。並已成功製造出寬30μm、長600μm之金電橋,單電橋電阻值約14Ω,並聯雙電橋約7Ω,三並聯電橋約4.5Ω,四並聯電橋約3Ω。 在電橋點火時物理性質上的探討,本文以數值方法為出發點,引用電哥尼能之觀念與電熱模式,在改變點火的模態與金屬電橋的尺寸下,模擬分析十種金屬之點火時間、發火能量與爆炸溫度,找尋出低發火能量與高爆炸溫度的材料與尺寸。 為避免高壓靜電引起點火藥意外點火,本文採用反向稽納二極體與 放電電路釋放靜電,反向稽納二極體的作用在於當正常點火電壓時,低的點火電壓不通過 放電接地端,因而正常地對金屬電橋點火;在靜電放電時,上萬伏靜電壓引起稽納二極體達到反向崩潰電壓,在奈秒的時間內快速地將靜電電壓導出點火晶片,有效地防止靜電走火。本文以數值分析模擬在1秒的人體靜電放放電時間作用下,推算電路所需連接的電阻與電容,模擬分析得到應連接放電時間常數τ等於0.26奈秒的電阻與電容,才可以同時滿足金電橋溫度低於點火藥鋯粉之點火溫度300℃與軍規安全靜電電壓100V以下。Micro Electromechanical Technology has made great progress,using the Process-skill to manufacture Electrical-Igniting-Chip to replace an old Exploding-Bridge-Wire,Electrical-Igniting-Chip has the advantage of lower firing energy、shorter ignition time、higher exploding temperature, etc. To switch an air bag of cars,to ignite bombs and rockets,to burn blunt master explosive,to ignite fuel to push ahead and is a kind of more reliable product. When it is an military use,it is set on an ignition device which has the ignition powder Zr in it ,and the Exploding Bridge Wire must pass the military standard of low firing energy test、low ignition time test、avoiding electrostatic discharge test and avoiding electromagnetic disturbing. In the manufacture of semiconductor process,use the process of yallow light、the process of thin film、the process of lift off to manufacture the Exploding Bridge Wire. And have successfully manufacture the golden Exploding Bridge Wire, the size of it is 30μm in wedth and 600μm in lenth. The single Exploding Bridge Wire is single or is parallel connection of two、three and four Exploding Bridge Wire,and each resistences is about 14Ω、7Ω、4.5Ω、3Ω. In the respect of firing energy and ignition time, this paper use the idea of mathematical method, use the formulas for Electrical Gurney Energy and Electrical Heat to analyse the ignition time、firing energy and exploding temperature of ten kind of metal of the every Exploding Bridge Wire size. Change the parameter of RCL discharge system to get the numerical solution, from the solution to find the material and size of low firing energy and high exploding temperature, and it is a reverse engineering. In the respect of avoiding electrostatic discharge causing the accident of ignition of Zr , use the Zenor diode of backward direction and RC discharge circuit , the discharged current of low voltage of capacitance doesn’t pass the RC element connected to ground terminal, and ignite the Exploding Bridge Wire. Thousands of electrostatic voltage break down the zenor diode of backward direction , and electrostatic voltage discharge in Exploding Bridge Wire in nano seconds to avoid electrostatic voltage igniting. We analyse the electrostatic voltage discharge in 1 sec by using the numerical method,to caculate the time constant of RC circuit. It shows that the time constant of RC circuit should be about 0.26 nano second to satisfy both conditions, the temperature of Exploding Bridge Wire is lower than the ignition temperature of the powder of Zr, which is 300℃, and the voltage of Exploding Bridge Wire is lower than the military standard of the safe electrostatic voltage .目次 頁次 摘要…………………………………………………...……………………..Ⅰ 目錄…………………………………………………...……………………..Ⅲ 附圖目錄……………………………………………...…....………...…….Ⅵ 附表目錄…………………………………………………..….…………....Ⅹ XI. 符號說明…………………………………………………………………. 第一章 緒論 1.1 引言…………………………………………………………….….…1 1.2 文獻回顧……………………………………………………….…….2 1.3 研究動機與本文內容………………………………………….…….5 第二章 電哥尼能理論與電熱原理 2.1 高電壓飛板撞擊點火………………………………………….…….7 2.1.1 電哥尼能理論………………………………………….……7 2.1.2 三夾層質量參數分析………………………………..….....10 2.2 低電壓電熱焦耳點火……………………………………….……...13 2.2.1 固態燃料在引燃器的點火燃燒….………………………..13 2.2.2 引燃器點火電路之相關原理…………...…………………15 2.2.3 金屬起爆相關原理………………………………………...16 2.2.4 電熱原理…………………………………………………...17 第三章 半導體製程研製晶片電橋 3.1 光罩設計……………………………………………………………19 3.2 製程…………………………………………………………………20 3.2.1 氧化熱製程…………………………………………………20 3.2.2 微影…………………………………………………………21 3.2.3 薄膜沉積……………………………………………………23 3.2.4 光阻掀舉……………………………………………………24 3.3 成品觀測與量測……………………………………………………24 第四章 電橋點火的模擬分析與討論 4.1 電橋在RLC放電電路的點火……………………………..……....26 4.1.1 過壓起爆模態……………………………………………...27 4.1.2 臨界點起爆模態…………………………………………...29 4.1.3 電橋線寬對發火能的影響………………………………...33 4.2 安全設計……………………………………………………………34 4.2.1 靜電………………………………………………………...34 4.2.2 防治靜電意外點火之電路設計及相關理論……………...35 4.2.3 靜電點火模擬之分析與討論……….……………………..40 第五章 結論與未來展 5.1 結論……………………………………………………...………....43 5.2 未來展望………...…….………………………………...…………45 參考文獻………………....………………....…………………...……...…46 附圖……………..……………………………………………………....…..48 附表…………………………………....………………………………...….72 附錄 製程參數表…………………….………………………………...…......7

    Appendix_clean_Jan9_ver2 – Supplemental material for Mental health during and after protests, riots and revolutions: A systematic review

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    Supplemental material, Appendix_clean_Jan9_ver2 for Mental health during and after protests, riots and revolutions: A systematic review by Michael Y Ni, Yoona Kim, Ian McDowell, Suki Wong, Qiu Hong, Irene OL Wong, Sandro Galea and Gabriel M Leung in Australian & New Zealand Journal of Psychiatry</p

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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