21 research outputs found
Biomaterials for Cartilage Regeneration
No full textOrthopedicsSurgerySCI(E)0EDITORIAL MATERIAL10674-6762
Mujeeb Khan. “The Two Ibn Sīnās: Negotiating Literature”
No full textThe author compares Ibn Sīnā’s medical poem as an expression of different perspectives on medical literature held by Ibn Sīnā. He is main interest is to discuss textual agency in the conceptualization of medical literature. The author argues that the organization of the poem, the use of examples, the inclusion of surgery, as well as the exclusion of various themes speak against previous interpretations as a simple, didactic tool for memorizing medical information. Instead of calling it didact..
On the Importance of Pooling Layer Tuning for Profiling Side-Channel Analysis
No full textIn recent years, the advent of deep neural networks opened new perspectives for security evaluations with side-channel analysis. Profiling attacks now benefit from capabilities offered by convolutional neural networks, such as dimensionality reduction and the inherent ability to reduce the trace desynchronization effects. These neural networks contain at least three types of layers: convolutional, pooling, and dense layers. Although the definition of pooling layers causes a large impact on neural network performance, a study on pooling hyperparameters effect on side-channel analysis is still not provided in the academic community. This paper provides extensive experimental results to demonstrate how pooling layer types and pooling stride and size affect the profiling attack performance with convolutional neural networks. Additionally, we demonstrate that pooling hyperparameters can be larger than usually used in related works and still keep good performance for profiling attacks on specific datasets.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Process, methods and tools for ship damage stability and flooding risk assessment
No full textDevelopment of damage stability as a scientific subject, specifically in damage ship hydrodynamics and, generally, flooding risk assessment, has evolved primarily by inquisitive academics with support by people with vision and passion towards maritime safety enhancement from industry and Government, the latter in the wake of serious accidents. Notwithstanding this, the subject has seen remarkable development in a short period of time in terms of understanding process, and developing methods and tools for practical implementation of such developments. The stage has now been reached where large-scale EC and industry-funded projects are bringing all requisite knowledge and experience together towards implementation by end users with the view to institutionalizing such developments. The paper critically traces and presents key developments starting from basic concepts to a complete framework for performing numerical simulations of ship survivability in operational conditions in the seaway, leading to flooding risk assessment with application potential for new and existing ships with focus on the design phase but with operation potential in ship operation, the latter involving emergencies
Peptide Bionanomaterials Global Market: The Future of Emerging Industry
No full textOver the years, the rising popularity of peptides has led to a paradigm shift in the focus of biotechnology and pharmaceutical industry from traditional molecular-based interventions to the development of multifaceted nanomaterial-based interventions. The ‘bench-to-bedside’ approach has enabled researchers to work with a variety of peptide-based bionanomaterials for applications in tissue engineering, regenerative medicine, drug delivery, biosensing and 3D printing, paving the way for clinical translation. Owing to the very nature of peptide molec-ular building blocks that form the basis of self-assembled biomaterials, the final materials exhibit extraordinary properties, such as biocompatibility, flexibility in design, reproducibility and stability, which help expedite their translation into different application domains within biomedicine. In this chapter, we highlight the clinical need for translation of peptide nanomaterials, outline current priority appli-cation areas and discuss how these are currently bridging gaps between academic and industrial research to support product development, scale up and adoption of technology. The chapter also outlines the substantial growth in global market size of peptide-based biomaterial products. Many examples of peptide nanomaterials include hydrogels as scaffolds and wound dressing materials; 3D printed nanostructures; and nanotubes as drug delivery vehicles and components for recon-struction of soft tissues and 3D cell culture. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Seedling Resistance to Stagonospora nodorum Blotch in Wheat Genotypes
No full textIn two independent experiments set up in the greenhouse the seedling resistance to Stagonospora nodorum blotch was investigated in 92 varieties, breeding lines and genotypes with a known genetic background. The greatest area under the disease progress curve calculated from lesion type was 37.06, while in the case of the most resistant genotype this value was 0.38. Many of the lines and varieties bred in Martonvásár proved to have excellent resistance in terms of both percentage of infected leaf area and lesion type. Observations indicate that, depending on the aim of the experiment, the efficient selection of breeding lines is possible in the seedling stage either on the basis of the area under the disease progress curve calculated for lesion types, or on the basis of lesion types scored 7, 11 or 14 days after inoculation
FlyPhoneDB2: A Computational Framework for Analyzing Cell-Cell Communication in Drosophila scRNA-Seq Data Integrating AlphaFold-Multimer Predictions
No full textCell-cell communication (CCC) plays a critical role in the physiological regulation of organisms and has been implicated in numerous diseases. Previously, we introduced FlyPhoneDB, a tool designed to explore CCC in Drosophila single-cell RNA-sequencing datasets. The core algorithm of FlyPhoneDB infers tissue-specific signaling events between cell types by calculating cell-cell interaction scores based on curated ligand-receptor (L-R) expression across major signaling pathways. However, the utility of FlyPhoneDB was limited by the relatively small number of available L-R pairs.
Here, we present FlyPhoneDB2, a major upgrade featuring a significantly expanded knowledgebase that includes a greater number of L-R pairs, incorporating annotations from mammalian species and structural predictions from AlphaFold-Multimer. In addition, the algorithm has been optimized for improved performance and more effective noise filtering. New functionalities have also been introduced, such as the addition of downstream reporter genes to evaluate pathway activity, multi-sample CCC comparison, and enhanced visualizations summarizing communication at a network level.
We demonstrate the utility of FlyPhoneDB2 by analyzing whole-body single-nuclei RNA-seq datasets from flies with gut tumors induced by the Yorkie oncogene. We show that FlyPhoneDB2 not only recapitulates established biological insights into the Drosophila Yorkie tumor model, but also identifies novel potential L-R pairs that may play important roles in tumor-induced cachexia. FlyPhoneDB2 is available at https://www.flyrnai.org/tools/fly_phone_v2/
Optimization of dual effects of Mg–1Ca alloys on the behavior of chondrocytes and osteoblasts in vitro
No full textAbstractMg ions can enhance the proliferation and redifferentiation of chondrocytes and the osteogenic differentiation of osteoblasts at specific concentrations, respectively. However, degradation of Mg alloys at varying degradation rates could lead to complex changes in the surrounding tissue environment, such as changes in the dynamic concentration of Mg ions and subsequent pH value. Considering the above mentioned factors, the comprehensive effects of Mg alloys on chondrocytes and osteoblasts behaviors have not yet been optimized. In this study, we evaluated the effects of Mg–1Ca microspheres on cell behavior with an aim to optimize conditions favorable for both cell types. Cells were cultured with Mg–1Ca microspheres prepared using the following concentrations: 250μg/ml, 500μg/ml and 1000μg/ml. At specific time points, cytotoxicity, expression of specific genes and extracellular matrix deposition by cells (Alizarin Red Staining of osteoblasts and Alcian blue staining for chondrocytes) were evaluated. The experimental results revealed that Mg–1Ca microspheres prepared at a concentration of 250μg/ml were optimum for both cell types, where chondrocytes were found to be in hypertrophy state while osteoblasts in close proximity to the microspheres showed osteogenetic differentiation. Interestingly, a slight change in osteoblasts behavior was observed nearer to and at a relative distance away from Mg–1Ca microspheres, an important observation for administering the application of microspheres as potential scaffolds
Combating stem and leaf rust of wheat: Historical perspective, impacts, and lessons learned
No full textmillions fed, food security, wheat rust, stem rust, leaf rust, Norman Borlaug,
Synthesizing social insurance research: A bibliometric analysis
No full textSocial insurance has been a pivotal tool in implementing social security. The purpose of the study is to analyze the existing information clusters (areas) in the field of social insurance. Clusters define related and unrelated groups in the field of social insurance. These groups will help streamline and identify areas where little or no research has been conducted to present. To achieve the objective, the study employed a precise and systematic procedure to gather 562 journal articles published in Scopus-indexed journals from 1926–2022. Subsequently, VOSviewer, Science of Science (Sci2), and Gephi were utilized to conduct bibliometric analysis (such as keyword co-occurrence and bibliographic coupling) and network analysis tests (such as citation and co-citation analysis). The results of keyword co-occurrence and co-citation analysis suggest there are three knowledge clusters: welfare provisions, benefits provided by social insurance, and social insurance operational aspects. Through analysis found top article-based Inequality, social insurance, and redistribution with 408(LC) and 1042(GC) and its page rank value is 0.010574 through prestigious analysis. Additionally, it is also observed that I. Nielsen had made the most substantial contributions as an author, with R. Smyth and C. Nyland following closely in the rankings. Also, observed maximum total link strength with 109 value on social security variable. The study also drawn attention to specific deficiencies, including regional concentration of research, insufficient research in developing and underdeveloped countries, inadequate knowledge sharing among researchers, limited methodological diversity, and a lack of research on the role of social insurance in facilitating society’s recovery from the pandemic
