218 research outputs found

    Corrigendum: Electronic medication monitoring-informed counseling to improve adherence to combination anti-retroviral therapy and virologic treatment outcomes: a meta-analysis

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    An error occurred with citations in the Discussion section. All citations of reference #22 (study from Rigsby et al.) on page 8, column 1, paragraph 2 and 3, should be replaced by citations of reference #24 (study from Sabin et al.). The correction does not affect the scientific validity of the results. AUTHOR CONTRIBUTIONS All authors listed, have made substantial, direct and intellectual contribution to the work, and approved it for publication

    Long-term mental health trajectories in recovered Covid-19 patients: exploring the interplay of psychosocial and biological factors affecting health-related quality of life

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    Long-term mental health and health-related quaity of life in hospitalized and ambulatory Covid-19 patients

    Impact of COVID-19 non-pharmaceutical mitigation measures on the multi-ethnic population health

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    Populations with a migration background and lower education/occupation groups were more vulnerable to negative changes related to mental health, income, healthy behaviors and access to non-COVID-19 health care during the early phase of the COVID-19 pandemic. In the current project we will explore whether these trends continued during the later phases of the pandemic and beyond, using detailed data from the HELIUS cohort study linked to registry data. We aim to assess the association between country-wide COVID-19 non-medical mitigation measures and mental health, cardiovascular risk, work status, income and health care use within ethnic and occupation groups, and whether these association changed over time. We will also explore to what extent COVID-19 preventive behaviors such as social distancing are linked to these life domains within ethnic and occupation groups

    Digital health technologies:Potential tools for promoting adherence to antiretroviral therapy among people living with HIV in Tanzania

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    Sufficiently high levels of adherence to ART are needed to achieve and maintain suppressed viral load. Despite the vast majority of people living with HIV(PLHIV) in Tanzania have access to ART, maintaining adherence to lifelong treatment thus seems to be a major challenge. Given the great penetration of mobile technology in Tanzania, digital health technology provides a unique opportunity to improve adherence to ART treatment.Therefore, this thesis investigates the impact of digital health technology as a potential tool to primarily support ART adherence and secondarily improve clinical outcomes among PLHIV in Tanzania. The first objective is to compare the effectiveness of two DATs, SMS and Real Time Medication Monitoring(RTMM), with standard care in promoting treatment adherence, using a randomized clinical trial, the so-called REMIND-HIV trial. Additionally, to examine the barriers and challenges participants encounter when using the DAT strategies. Lastly, to examine to what extent the adherence measures, including pharmacy refill counts, self-reported adherence and RTMM, predict virologic suppression.This thesis produced important findings on the effectiveness and implementation of DATs in influencing adherence to ART treatment. In our investigation, DATs have the potential to enhance the delivery of quality HIV care, particularly for communities that are hard-to-reach and having limited resources-settings. Furthermore, our studies indicate that DAT have the potential to raise awareness about the importance of ART adherence and improve patient-nurse communication during clinic visits. We recommend that several challenges learned from this study need to be considered to ensure that DATs are sustainable, feasible and acceptable

    Combination antiretroviral therapy among immigrant and indigenous HIV infected patients: quality of life and treatment adherence

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    Hiv-patiënten ervaren door medicijngebruik en hun ziekte veel symptomen. Ook hebben ze een lagere kwaliteit van leven en faalt hun behandeling vaker. De slechte levenskwaliteit vergroot de kans op overlijden en werkt negatief door op therapietrouw. Marion de Boer deed onderzoek naar therapietrouw bij geïmmigreerde en autochtone hiv-patiënten. Het meten van therapietrouw op basis van apotheekgegevens is betrouwbaar en hangt samen met de uitkomst van de behandeling. Zelfrapportage van therapietrouw is minder betrouwbaar omdat sociaal wenselijke antwoorden worden gegeven. De therapietrouw is lager bij immigranten; daardoor slaat therapie minder vaak aan
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