31,737 research outputs found
Substrate control by means of the chiral cavity of prolinamide derivatives of cholic acid in the organocatalyzed Michael addition of cyclohexanone to nitroolefins
No full textDifferent prolinamide and bis-prolinamide derivatives were checked as organocatalysts in the asymmetric
Michael addition of cyclohexanone to aromatic nitroolefins, and the derivative bearing a D-prolinamide
moiety linked at the 7-position emerged as the most efficient, giving the Michael adducts in
satisfactory yield and ees of up to 95%. The corresponding system having a free OH group at the 3-position
of the cholestanic backbone afforded the opposite enantiomer of the product, suggesting that the
transition state is developed at the inner part of the cholestanic cavity, which is responsible for the substrate
control determining the stereochemical outcome of the reaction
Michael Rodriguez interviews fiction writer Michael Kimball
No full textAuthor Michael Kimball talks about moving away from Michigan to become a successful writer, his education, the fiction reading series he has started in Baltimore, the life-story-on-postcard project, and his book "Dear everybody." Kimball is interviewed by Michigan State University Librarian Michael Rodriguez for the Michigan State University Libraries' Michigan Writers Series
Michael Rodriguez interviews author Paul Clemens
No full textAuthor Paul Clemens talks about his book "Made in Detroit," the genre of memoir, and writing about race. Clemens is interviewed by Michigan State University Librarian Michael Rodriguez for the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
Michael Rodriguez interviews author Tom Springer
No full textAuthor Tom Springer is interviewed about his writing career and his newest book "Looking for hickories". Springer talks about his career following after earning an Environmental Journalism degree from Michigan State University. He calls his genre "creative non-fiction" and explains how he weaves his memories into his books about life in rural and wild Michigan. Part of the Michigan State University Libraries' Michigan Writers Series. Springer is interviewed by Librarian Michael Rodriguez
Michael Rodriguez interviews author Gary Gildner
No full textAuthor Gary Gildner explains why he left his tenured teaching position to move to Idaho to became a full-time writer of poetry. Gildner talks about donating his personal papers to Michigan State University Libraries' Special Collections, his writing style and how he approaches writing. Gildner is interviewed by MSU Librarian Michael Rodriguez for the MSU Libraries' Michigan Writer Series. Held at the MSU Main Library
Gold standard of UK degrees is lost in translation
No full textInflated marks, overworked staff and politically compromised courses are the price of exploiting offshore UK registered students, says Michael Day
Michael Rodriguez interviews historian and author Keith Widder
No full textHistorian and author Keith Widder talks about his move to Michigan from Wisconsin, his career as Curator of History for the Mackinac Island State Park Commission, his research interests, his book "Michigan Agricultural College", and his current projects. Widder is interviewed by Michigan State University Librarian Michael Rodriguez for the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
Synthesis and use of bile acid derived organocatalysts
No full textThe central idea of this work was design, synthesis and study of catalytic activity and enantioselectivity of new organocatalysts containing a chiral cavity mimicking the enzymatic pocket of Aldolase I. Following the longstanding interest of our research group in the use of bile acid derivatives in enantioselective processes, attention was addressed to the development of organocatalysts having bile acid structure, where, because of its concave structure, due to the cis junction of the A and B cyclohexanic rings (Figure 3), the cholestanic backbone and the appended substituents should form a chiral cleft that can help the enantioselection. In addition, the presence of free hydroxyl groups can constitute a further advantage by controlling, via hydrogen bonds, the position of the substrate in the cavity of organocatalyst.
In particular in this project were synthesized:
· A wide class of monoprolinamide derivatives of bile acids, in order to find the right match between proline and cholestanic backbone. In particular synthesis of proline derivatives in different position of bile acid could throw light on the influence of position of proline moiety in the cholestanic emicavity on selectivity of organocatalyst.
· A class of bisprolinamide derivatives of bile acids that could take advantage from the cooperative effect of two proline moieties.
In designing synthesis of these derivatives attention has been paid to the use of low cost, easy and fast procedures in order to improve availability of the new organocatalysts.
Activity and enantioselectivity of this new organocatalysts have been studied with particular attention to:
· Aldol reaction
· Michael reaction
During the activity studies evaluation of parameters that can improve rate of different reaction (temperature, solvents, catalyst loading, reagents...) was considered. The possibility to carry out reactions in water and with very low catalyst loading was checked, in order to evaluate ecosostenibility of the chemical process.
Experimental results were collected and analyzed with the help of conformational and computational studies
Dr. Michael Janis, Morehouse College, August 2011, August 2011
No full textThis video is a conversation with Dr. Michael Janis. Dr. Janis talks about his book, "Africa After Modernism: Transitions in Literature, Media and Philosophy". Yolanda Gilmore-Bivins, AUC Woodruff Library, is the interviewer
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
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