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A uterus soaked in blood with low haemoglobin in a case of unrecognized uterine sarcoma
No full textIntroduction: Uterine sarcomas are rare and aggressive tumors. In some cases they can cause rupture of the uterus with or without clinical and radiological symptoms. Therefore, it is important to observe patients with clinical and/or radiological suspicion of sarcoma, even when there are no clinical manifestations. Case report: A 71-year old woman, who was under the authors' observation for pain in the right iliac fossa. The US and the CT scan showed an abdominal-pelvic mass.Laboratory tests showed a slight but progressive reduction of haemoglobin, which could not be explained by the clinical symptoms and by the results of the imaging tests. During the surgical intervention, a small amount of peritoneal fluid, an increased uterine volume, and a subverted anatomy were observed A haematoma was found in the uterus and this could explain the progressive reduction of haemoglobin and the very low presence of peritoneal effusion. Conclusion: The rupture of the uterus could not have been suspected as the patient did not have any type of symptoms, except for the slow and progressive reduction in the haemoglobin value. Therefore, it is important to observe patients with clinical and/or radiological suspicion of sarcoma, even when there are no clinical manifestations
Effects of pomegranate juice and extract polyphenols on platelet function
No full textSeveral studies have shown that polyphenols reduce cardiovascular accidents in high-risk patients; in particular,
the inhibition of platelet function may be responsible for part of this benefit. This research studied the antiplatelet effect
of Wonderful variety pomegranate (Punica granatum) products, which contain primarily hydrolyzed tannins such as ellagitannins.
We have investigated in vitro the effects of treatment with either pomegranate juice (PJ) or the polyphenol-rich extract
from pomegranate fruit (POMx) on platelet aggregation, calcium mobilization, thromboxane A2 production, and hydrogen
peroxide formation, induced by collagen and arachidonic acid. PJ and POMx reduce all the platelet responses studied.
POMx showed a stronger action in reducing platelet activation; moreover, POMx is active at the concentration that it is possible
to obtain after polyphenol-rich food intake (2 M). These results demonstrated that the cardiovascular health benefits
of pomegranate may in part be related to the ability of polyphenols to inhibit platelet function. In fact, PJ and pomegranate
extract have similar effects at concentrations expected for normal intake
DIFFERENTIAL AGGREGATION OF THROMBIN-DEGRANULATED HUMAN PLATELETS IN RESPONSE TO ADP, EPINEPHRINE AND SQ26655.
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Interindividual variability of platelet sensitivity to aspirin is due to impaired platelet COX-1/Aspirin interaction
No full textIntracellular signalling of epinephrine in rat hepatocytes during fetal development and hepatic regeneration
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Collagen-induced platelet thromboxane A2 production in patients chronically treated with aspirin
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Aspirin does not equally inhibit thromboxane A2 formation in long-term treated patients
No full textSydney Australi
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