1,720,997 research outputs found
How the Seven Countries Study contributed to the definition and development of the Mediterranean diet concept: a 50-year journey
No full textAbstract The Seven Countries Study of Cardiovascular Diseases was started at the end of the
1950s and it continues to be run after >50 years. It enrolled, at entry, 16 population cohorts in
eight nations of seven countries for a total of 12,763 middle-aged men. It was the prototype of
epidemiological studies seeking cultural contrasts and the first to compare cardiovascular disease
(CVD) rates related to diet differences. The study has shown that populations suffer widely
different incidence and mortality rates from coronary heart disease (CHD) as well as from other
CVDs and overall mortality. Higher rates were found in North America and northern Europe, and
lower rates in southern Europe e Mediterranean countries e and Japan. These differences in
CHD rates were strongly associated with different levels of saturated fat consumption and
average serum cholesterol levels, with lowest rates in Greece and Japan where the total fat intake
was very different. The cohorts were also different in dietary patterns defined by the ratio of calories
derived from plant foods and fish on the one hand and calories derived from animal foods
and sugar on the other. These findings pointed to the so-called Mediterranean diet, which is
characterized by large values of that plant/animal ratio, a pattern associated with lower incidence
and mortality from CHD and also with the lowest death rates and the greatest survival
rates. More recent studies have refined these concepts and documented on a larger scale the virtues
of these eating habits
Ultrastructure of superfused human atrial muscles before and after stimulation of contractile activity.
No full textInsight into the pathophysiological mechanisms underlying heart and brain interaction: clinical, neuroimaging, and pharmacological predictors of troponin I elevation in acute stroke
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L'importanza dello studio ecocardiografico nella valutazione della cardiopatia ipertensiva
No full textMolecular myocardial injury biomarkers in acute stroke: prognostic significance of troponin I changes
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Red blood cell count in short-term prediction of cardiovascular disease incidence in the Gubbio population study.
No full textAumento della conduttanza al potassio ed attività elettrica spontanea "in vitro": confronto tra nicorandil e cicletanine.
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