1,720,966 research outputs found
A REVIEW OF TESTICULAR INTRATUBULAR GERM-CELL NEOPLASIA IN INFERTILE MEN
No full textA group of 2,739 infertile men whose testes were biopsied during the investigation of infertility in the period from January 1955 to December 1992 have been reviewed. Unilateral intratubular germ cell neoplasia was seen in the testicular biopsies of 16 patients and was always associated with testicular atrophy (Johnsen score lower than 4). Germ cell tumors of the testis occurred in 50% of untreated patients within 6 years and the longest period of tumor-free follow-up was 10 years. A retrospective study was performed to evaluate the incidence of tumors in a subset of 1,639 infertile men biopsied between 1955 and 1982. Three of the patients, without intratubular germ cell neoplasia on the biopsy, were found to have developed a germ cell tumor. The incidence and management of intratubular germ cell neoplasia in infertile men is discussed
Pedicled pubic phalloplasty in females with gender dysphoria
No full textOBJECTIVE:
To describe a novel phalloplasty technique and to study the results and complications in female patients with gender dysphoria.
PATIENTS AND METHODS:
Between 1989 and 2000, 85 female-to-male transsexual patients had a phalloplasty fashioned from suprapubic abdominal wall flap that was tubed to form the phallus, and which incorporated the neourethra made from a pedicled tube of labial skin. The complete neourethral reconstruction was in one stage in 32 patients and in two in 48; five patients did not wish to have the neourethra fashioned.
RESULTS:
The cosmetic appearance of the phallus was considered good in 68% of the patients. The major complications (in 60 patients) were related to the neourethra (75%) with stricture formation (64%) and/or fistulae (55%) predominating. This complication rate was significantly less (P < 0.001) when the neourethra was created in two stages. Once the neourethra was completed, patients were then offered both penile and testicular prostheses. Sexual intercourse was possible with no prosthesis in 16 patients.
CONCLUSIONS:
The pubic phalloplasty offers an acceptable neophallus without disfiguring the donor skin site. The main complications stem from creating the neourethra and these may be reduced by a two-stage procedure
Clinical aspects associated with Sertoli-cell-only histology
No full textObjective To assess the clinical features found in infertile men in whom the histological diagnosis of Sertoli-cell-only (SCO) was made on testicular biopsy. Patients and methods A retrospective review was carried out of the seminal fluid analysis, testis size and follicle-stimulating hormone (PSR) levels of 72 men who had bilateral testicular biopsies due to infertility when one (30) or both (42) of bilateral testicular biopsies showed tubules containing only Sertoli cells. Ln a subgroup of 15 men, the biopsies were re-examined to correlate the morphological features with the plasma FSH level. Results When both biopsies showed bilateral SCO the patient bad azoospermia (86%) or oligozoospermia (14%): the testicular size was normal in 36% and the FSH level was normal (43%), raised (21%) or grossly elevated (more than twice normal, 36%), When one biopsy showed SCO, the opposite testis showed appearances which varied from grossly impaired spermatogenesis to almost normal spermatogenesis. The clinical findings were also very variable. Conclusions The clinical features associated with the histological diagnosis of SCO are extremely variable, Biopsy evidence of bilateral SCO cannot be relied upon to indicate a total absence of spermatogenesis in the testes
Sildenafil: Efficacy and safety in daily clinical experience
No full textObjectives: Sildenafil citrate (Viagra (TM)) is a potent selective inhibitor of phosphodiesterase type 5 proposed for the oral treatment of erectile dysfunction (ED). The aim of this study was to evaluate its efficacy and safety when used in daily practice in patients with ED of various aetiology. Patients and Methods: From September 1998 to April 1999, 380 patients chose sildenafil as treatment for their ED. One hundred and forty-five (38%) of them suffered from psychogenic ED, 125 (33%) organic and 110 (29%) of mixed aetiology. The grade of erection achieved and the occurrence of satisfactory sexual intercourse assessed the efficacy. Safety and tolerance were evaluated recording any side effect or adverse event. Results:The overall efficacy of Viagra (TM) was 77%, with a response of 100% among the group of hormonal patients, 88% for psychogenic, 72% for mixed, 69% for diabetes, 65% for vascular and 60% for neurological symptoms. A few and mild to moderate side effects were recorded. Conclusion:These results indicate that the use of sildenafil citrate is an effective and well-tolerated therapy for men with ED of various aetiology with an overall success rate of 77%. Copyright (C) 2001 S. Karger AG, Basel
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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