170,094 research outputs found
Pruss o wymogu powszechnej miłości
No full textW swojej znakomitej książce One Body Alexander Pruss opiera się na przekonaniu, że istnieje wymóg powszechnej miłości: wszyscy jesteśmy zobowiązani do wzajemnej miłości. Zawarte w niniejszej pracy tezy Pruss w dużej mierze uzasadnia, odwołując się do prawdy objawionej, mimo to wymóg powszechnej miłości wzmacnia argumentacją filozoficzną. Ten sposób argumentacji nazywam „argumentem z wrażliwości na wartość”. Jego podstawą jest przekonanie, że wszyscy ludzie posiadają pewien rodzaj wsobnej wartości, która to wartość dostarcza wszystkim innym podmiotom racji, aby odpowiedzieć na nią pozytywnie, stąd każdy człowiek jest zobowiązany do miłości drugiego człowieka. W niniejszym artykule dyskutuję z tym argumentem, zwracając uwagę na jego dwie istotne słabości: pierwsza z nich dotyczy tego, jakiego rodzaju racji dostarcza wartość osoby, a druga tego, na ile odpowiedź na ową wartość musi być odpowiedzią miłości.Throughout his excellent book One Body, Alex Pruss relies upon the view that there is a requirement of universal love: each and every one of us is required to love each and every one of us. Although he often appeals to revealed truth in making arguments for his various theses, he supports the requirement of universal love primarily through a philosophical argument, an argument that I call the “argument from responsiveness to value.” The idea is that all persons bear a sort of nonrelational value, and because this value gives every agent reasons to respond to it positively, each and every person is bound to love each and every person. The aim of this paper is to criticize this argument. Pruss’s argument has two important gaps, one concerning the sort of reasons that the value of persons gives and one concerning whether the required response is the response of love
MUTATIONS IN NADH-UBIQUINONE OXIDOREDUCTASE OF ESCHERICHIA-COLI AFFECT GROWTH ON MIXED AMINO-ACIDS
No full textWe isolated and characterized mutants defective in nuo, encoding NADH dehydrogenase I, the multisubunit complex homologous to eucaryotic mitochondrial complex I. By Southern hybridization and/or sequence analysis, we characterized three distinct mutations: a polar insertion designated nuoG::Tn10-1, a nonpolar insertion designated nuoF::Km-1, and a large deletion designated A(nuoFGHIJKL)-1. Cells carrying any of these three mutations exhibited identical phenotypes. Each mutant exhibited reduced NADH oxidase activity, grew poorly on minimal salts medium containing acetate as the sole carbon source, and failed to produce the inner, L-aspartate chemotactic band on tryptone swarm plates. During exponential growth in tryptone broth, nuo mutants grew as rapidly as wild-type cells and excreted similar amounts of acetate into the medium. As they began the transition to stationary phase, in contrast to wild-type cells, the mutant cells abruptly slowed their growth and continued to excrete acetate. The growth defect was entirely suppressed by L-serine or D-pyruvate, partially suppressed by alpha-ketoglutarate or acetate, and not suppressed by L-aspartate or L-glutamate. We extended these studies, analyzing the sequential consumption of amino acids by both wild-type and nuo mutant cells growing in tryptone broth. During the lag and exponential phases, both wild-type and mutant cells consumed, in order, L-serine and L-aspartate. As they began the transition to stationary phase, both cell types consumed L-tryptophan. Whereas wild-type cells then consumed L-glutamate, glycine, L-threonine, and L-alanine, mutant cells utilized these amino acids poorly. We propose that cells defective for NADH dehydrogenase I exhibit all of these phenotypes, because large NADH/NAD(+) ratios inhibit certain tricarboxylic acid cycle enzymes, e.g., citrate synthase and malate dehydrogenase
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Stratified Archaeological Evidence and Compared Periodizations in the Syrian Jezirah during the Third Millennium BC
No full textFIGURE 5 in A new phosphatized ophiuroid from the lower Triassic of Nevada and its position in the evolutionary history of the Ophiuroidea (Echinodermata)
No full textFIGURE 5: Dissociated disc plates of the ophiuroid Ophiosuperstes praeparvus gen. et sp. nov., from the Virgin Limestone Member of the Moenkopi Formation, Spathian, lower Triassic, Lost Cabin Springs locality, southern Nevada. A: paratype (OPH188), oral plate in abradial view. B: paratype (OPH189), radial shield in external view, with outline of missing proximal tip reconstructed using a dashed grey line. C: paratype (OPH190) adradial genital plate in dorsal view. Abbreviations: AMF: abradial muscle fossa; do: dorsal; LG: longitudinal groove; pr: proximal. All scale bars equal 0.2 mm.Published as part of Thuy, Ben, Maxwell, Vivienne & Pruss, Sara B., 2021, A new phosphatized ophiuroid from the lower Triassic of Nevada and its position in the evolutionary history of the Ophiuroidea (Echinodermata), pp. 369-383 in Zootaxa 5071 (3) on page 378, DOI: 10.11646/zootaxa.5071.3.4, http://zenodo.org/record/572374
Triga Controversiarum Philosophicarum, I. Donatione Constantini M. II. De Noctivagis, III. Materia Ventorum / Quam Auxiliante D. O. M. Suffragio Amplissimae Facultatis Philosophicae, Praeside M. Michaele Hoynovio, Disputationi publicae committet Daniel Hoynovius, Milca Pruss. SS. Theol. & Phil. Stud. Autor & Respondens. In Auditorio Minori, H. L. Q. S. Anno M D C LXXXIIX. d. [ ] Novembr.
No full textTRIGA CONTROVERSIARUM PHILOSOPHICARUM, I. DONATIONE CONSTANTINI M. II. DE NOCTIVAGIS, III. MATERIA VENTORUM / QUAM AUXILIANTE D. O. M. SUFFRAGIO AMPLISSIMAE FACULTATIS PHILOSOPHICAE, PRAESIDE M. MICHAELE HOYNOVIO, DISPUTATIONI PUBLICAE COMMITTET DANIEL HOYNOVIUS, MILCA PRUSS. SS. THEOL. & PHIL. STUD. AUTOR & RESPONDENS. IN AUDITORIO MINORI, H. L. Q. S. ANNO M D C LXXXIIX. D. [ ] NOVEMBR.
Triga Controversiarum Philosophicarum, I. Donatione Constantini M. II. De Noctivagis, III. Materia Ventorum / Quam Auxiliante D. O. M. Suffragio Amplissimae Facultatis Philosophicae, Praeside M. Michaele Hoynovio, Disputationi publicae committet Daniel Hoynovius, Milca Pruss. SS. Theol. & Phil. Stud. Autor & Respondens. In Auditorio Minori, H. L. Q. S. Anno M D C LXXXIIX. d. [ ] Novembr. (1)
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A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
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