337 research outputs found
Love elegies ...
No full textAttributed to William Hayley. cf. Wrenn catalogue.Engraved title vignette.Mode of access: Internet
Palliative care research centre's move into social media: constructing a framework for ethical research, a consensus paper
No full textBackground Social media (SM) have altered the way we live and, for many, the way we die. The information available on even the rarest conditions is vast. Free from restrictions of mobility, time and distance, SM provides a space for people to share experiences of illness, death and dying, and potentially benefit from the emotional and practical support of others n similar positions. The communications that take place in these spaces also create large amounts of ‘data’ which, for any research centre, cannot be ignored. However, for a palliative care research centre the use of this ‘data’ comes with specific ethical dilemmas.
Methods This paper details the process that we, as a research, went through in constructing a set of ethical guidelines by which to work. This involved conducting two consensus days; one with researchers from within the centre, and one with the inclusion of external researchers with a specific interest in SM.
Results The primary themes that emerged from the consensus meetings includes; SM as a public or private space; the status of open and closed groups; the use of historical data; recruiting participants and obtaining informed consent and problems of anonymity associated with dissemination.
Conclusions These are the themes that this paper will focus on prior to setting out the guidelines that we subsequently constructed
Considerations and recommendations for conducting qualitative research interviews with palliative and end-of-life care patients in the home setting: a consensus paper
No full textObjectives To present and discuss the views of researchers at an academic palliative care research centre on research encounters with terminally ill patients in the home setting and to generate a list of recommendations for qualitative researchers working in palliative and end-of-life care.
Methods Eight researchers took part in a consensus meeting to discuss their experiences of undertaking qualitative interviews. The researchers were of varying backgrounds and all reported having experience in interviewing terminally ill patients, and all but one had experience of interviewing patients in their home environment.
Results The main areas discussed by researchers included: whether participation in end-of-life research unintentionally becomes a therapeutic experience or an ethical concern; power relationships between terminally ill patients and researchers; researcher reflexivity and reciprocity; researchers’ training needs. Qualitative methods can complement the home environment; however, it can raise ethical and practical challenges, which can be more acute in the case of research undertaken with palliative and patients at the end-of-life.
Conclusions The ethical and practical challenges researchers face in this context has the potential to place both participant and researcher at risk for their physical and psychological well-being. We present a set of recommendations for researchers to consider prior to embarking on qualitative research in this context and advocate researchers in this field carefully consider the issues presented on a study-by-study basis
The application of capillary electrophoresis to examine protein modifications in baked versus fried tortilla chips
No full textAlthough lipid oxidation is recognized as a major chemical reaction limiting shelf life of foods, its role in degrading food quality and the mechanisms involved remain incompletely elucidated. Interactions of oxidizing lipids with other food molecules have been largely ignored, even though these reactions can have dramatic impact on food properties. Lipid co-oxidation of proteins occurs extensively in nearly all processed foods and degrades textures, flavors, color, and nutritional value. It is important to measure both lipid and protein co-oxidation products to understand the full extent of oxidative deterioration during food storage. This thesis is part of a larger project examining baked and fried tortilla chips to differentiate thermal damage to proteins from lipid co-oxidation during processing and storage. In a previous study, gel electrophoresis revealed modification of protein surfaces that affected dye binding, as well as formation of sizeable protein aggregates too large to enter normal gels involving disulfide, free radical, and other crosslinks. As an alternative to polyacrylamide gels, capillary electrophoresis can separate peptides without molecular weight limits, by modes that may be more sensitive to side chain modifications, and requires only a few nanoliters of sample. Thus, this study investigated the use of capillary electrophoresis for tracking fragmentation and crosslinking in co-oxidized proteins. Results corroborated observations that fried tortilla chip samples had greater changes than baked tortilla chip samples and higher incubation temperature resulted in more protein damage, most notably in fried reducing fractions. In addition, surface modifications altered protein charge, which interfered with migration in capillary electrophoresis. Peptide detection was limited to zeins of about 50 kDa because the sample filtration step intended to prevent capillary blockage also removed higher molecular weight fractions, including glutelins. However, fragmentation products not distinguishable in gel electrophoresis were detected. Overall, results of this study suggest that capillary electrophoresis has intriguing possibilities for supplementing SDS-PAGE and other protein analyses, particularly in verifying the presence of surface modifications. However, significant hurdles—such as reasons for lack of high molecular weight peptide loading and migration—remain to be overcome before capillary electrophoresis can become a primary method for analysis of modified proteins.M.S.Includes bibliographical referencesby Lisa Hayley Schult
Hayley's biography of Dante
No full textWilliam Hayley’s literary relationship with Dante had a central role in the rediscovery of the Italian poet at the turn of the nineteenth century in England. His knowledge of Dante likely dates back to his student years at Trinity Hall in the 1760s, when he learned “to read, write, and speak Italian with fluency” from his master Agostino Isola, “an elderly, ingenious and distressed Italian” who taught in Cambridge. Hayley invoked Dante in The Triumphs of Temper (1781) and An Essay on Epic Poetry (1782) and was one of the earliest to attempt rendering the Commedia from the original terza rima, offering the most extended English version available in print at the time. The translation was first published in his notes to An Essay on Epic Poetry and encompassed the first three cantos of Inferno. Contemporary writers’ views on his Dante translation, particularly those expressed by Anna Seward and Horace Walpole, are significant. Seward had little admiration for “the fire and smoke poet” and Walpole was notorious for his hostility to Dante. However, they greatly admired Hayley’s version, even more so than Boyd’s. In a letter to Helen Williams, Seward confesses that “after reading and comparing it with Mr. Hayley’s sublime English version of the three first cantos, we cannot place great confidence in Boyd’s justice to his author” (25 August 1785). Boyd himself praised Hayley’s translation and highlighted that in his edition “many biographical particulars of Dante, are taken from Mr. Hayley’s Notes to his Essay on Epic Poetry.” But Hayley’s An Essay on Epic Poetry, apart from his acclaimed translation of the Commedia, includes other noteworthy parts such as his translations of sonnets by Dante, Petrarch, and Camõens and a series of European poets’ biographies, including those of Dante, Boccaccio, and Tasso. In his sketch of Dante’s life, Hayley emphasizes “the lighter graces of sprightly composition,” going beyond the common perception of Dante as a poet “inclined to melancholy.” Hayley’s notes raise questions about the readership of Italian poetry at the time, particularly in what way poets such as Dante were introduced to the English reader, and how the inclusion of Dante’s biography in An Essay might have contributed to the reception of his verse-in-translation. This chapter revolves around the exploration of these concerns in order to contextualize Hayley as a prominent figure who, besides his important connections to Blake and Romney, crucially contributed to literary and artistic negotiations across borders.</p
Patients’ Experiences of LIving with CANcer-associated thrombosis: the PELICAN study
No full textSimon Noble, Hayley Prout, Annmarie Nelson Marie Curie Palliative Care Research Centre, Cardiff University, Cardiff, Wales, UK Introduction: Thrombosis remains the most common preventable cause of mortality in cancer patients receiving chemotherapy. Whilst the prophylaxis and treatment of this condition is well understood, the patient experience and subsequent behavioral factors are not. Methods: Patients receiving treatment for cancer-associated thrombosis (CAT) were interviewed about their experiences of CAT within the context of their cancer journey. Twenty interviews were transcribed and analyzed using framework analysis. Results: Chemotherapy patients were well informed about the risks of febrile neutropenia, how to recognize it, and when to seek medical attention. However, they had limited knowledge about CAT and received no information about the condition. Red flag symptoms suggestive of CAT were attributed to chemotherapy or the underlying cancer, resulting in delayed presentation to hospital, and diagnosis. The CAT journey was considered a distressing one, with limited support or information, in complete juxtaposition with the treatment they received for their cancer. Patients felt there was little ownership for the management of CAT, which further added to their distress. Conclusion: CAT is a common occurrence and patients view their experiences of it within the context of their overall cancer journey. However, patients receive little information to help recognize CAT and access timely treatment on the development of symptoms. Whilst other cancer complications have clear treatment pathways, thrombosis does not appear to have been afforded the same priority. A proactive approach to increase patient awareness, coupled with established CAT pathways is likely to reduce mortality, morbidity, and long-term psychological distress. Keywords: venous thromboembolism, qualitative, patient journey, low-molecular-weight heparin, patient experienc
Cutting edge: Basophils are transiently recruited into the draining lymph nodes during Helminth infection via IL-3, but infection-induced Th2 immunity can develop without Basophil lymph node recruitment or IL-3
No full textData source: Supplementary material, http://www.jimmunol.org/content/suppl/2009/12/28/jimmunol.0902447.DC1Basophils are recognized as immune modulators through their ability to produce IL-4, a key cytokine required for Th2 immunity. It has also recently been reported that basophils are transiently recruited into the draining lymph node (LN) after allergen immunization and that the recruited basophils promote the differentiation of naive CD4 T cells into Th2 effector cells. Using IL-3−/− and IL-3Rβ−/− mice, we report in this study that the IL-3/IL-3R system is absolutely required to recruit circulating basophils into the draining LN following helminth infection. Unexpectedly, the absence of IL-3 or of basophil LN recruitment played little role in helminth-induced Th2 immune responses. Moreover, basophil depletion in infected mice did not diminish the development of IL-4–producing CD4 T cells. Our results reveal a previously unknown role of IL-3 in recruiting basophils to the LN and demonstrate that basophils are not necessarily associated with the development of Th2 immunity during parasite infection.Sohee Kim, Melanie Prout, Hayley Ramshaw, Angel F. Lopez, Graham LeGros and Booki Mi
Ode inscribed to John Howard: Esq. F.R.S. author of "The state of English and foreign prisons." By William Hayley, Esq.
No full textOde inscribed to John Howard: Esq. F.R.S. author of "The state of English and foreign prisons." By William Hayley, Esq.
No full text19,[1]p.,plate ; 4⁰.With a half-title.Reproduction of original from the British Library.English Short Title Catalog, ESTCT89526.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)
Ode inscribed to John Howard: Esq. F.R.S. author of "The state of English and foreign prisons." By William Hayley, Esq.
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