1,721,601 research outputs found
Tavole anatomiche
No full textTavole anatomiche disegnate dal vero di Giovanni Girardi, anatomico.
Le tavole sono litografie in bianco e nero, originariamente 7, mancante la n. 6.
Sono state stampate nello Stabilimento Prosperini di Padova, 1927
Accidental falls and imbalance in multiple sclerosis: diagnostic challenges, neuropathological features and treatment strategies
No full textBest Oral Presentation during the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis 18th Annual Conference of Rehabilitation in Multiple Sclerosis
No full text
Dimethyl fumarate in the management of multiple sclerosis: Appropriate patient selection and special considerations
Full text linkDelayed-release dimethyl fumarate (DMF), also known as gastroresistant DMF, is the most recently approved oral disease-modifying treatment (DMT) for relapsing multiple sclerosis. Two randomized clinical trials (Determination of the Efficacy and Safety of Oral Fumarate in Relapsing–Remitting MS [DEFINE] and Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis [CONFIRM]) demonstrated significant efficacy in reducing relapse rate and radiological signs of disease activity, as seen on magnetic resonance imaging. The DEFINE study also indicated a significant effect of DMF on disability worsening, while the low incidence of confirmed disability worsening in the CONFIRM trial rendered an insignificant reduction among the DMF-treated groups when compared to placebo. DMF also demonstrated a good safety profile and acceptable tolerability, since the most common side effects (gastrointestinal events and flushing reactions) are usually transient and mild to moderate in severity. Here, we discuss the place in therapy of DMF for individuals with relapsing multiple sclerosis, providing a tentative therapeutic algorithm to manage newly diagnosed patients and those who do not adequately respond to self-injectable DMTs. Literature data supporting the potential role of DMF as a first-line therapy are presented. The possibility of using DMF as switching treatment or even as an add-on strategy in patients with breakthrough disease despite self-injectable DMTs will also be discussed. Lastly, we argue about the role of DMF as an exit strategy from natalizumab-treated patients who are considered at risk for developing multifocal progressive leukoencephalopathy
“ACTIWI” Sistema con serramento adattivo per ottimizzare l’isolamento indoor
No full textAbstract
The research topic involves the design of technological system lower energy consumption and able to improve allowing a thermal performance of buildings, according to the logic of NZEB (Near Zero Energy Building). The major role is assigned to new features applied to the traditional system of the window. In order to achieve this goal, the research focuses on the relationship between academic studies and companies’ experience working in the Marche region. Thus, a know-how must be received by the companies, being able to ensure a good teaching for the project. The introduction explores the state of the art concerning the building masonries built after the mid 1900s, detecting the low thermal e ciency for the residences, often without any insulation. The- refore, the research aims to apply a new insulating frame, assembled with the window, in order to improve the energy saving and the indoor heating comfort. Moreover, the work aims to organize the interior space, using a precast dry wall system, associated to thermal detectors. Dry systems, thanks to their technological evolution, allow to achieve energy results in the eld of façades, due to the opaque walls organize the indoor habitat. For this reason, the construction industry wants to decrease the incidence of heat loss in exterior walls, especially in the buildings built during the post-war period. At the time, many buildings have a certain thermal vulnerability today, because they have not an adequate insulation in the wall. In the second part, the research has been analy- sed several masonries, in order to verify the best system to be applied above the current wall. In- deed, it is necessary to create an insulating connection between the new and the old wall, leaving intact the current one, using only the part of the old structure. In addition, a correct design to is needed assemble all frame elements: often some evidences, identify the weak thermally junction between the window frame and the masonry. To overcome these problems, the research wants to embed a prefabricated structure, to reach quickly and easily an abatement of dispersions. The technologic design resumes the dry system idea, based on the criteria of lightness and thermal performance. The retro t corrects the thermal loss and it increases the indoor comfort, with the aid of materials and construction techniques. Finally, building energy performance should be com- bined with an aesthetical study, to improve the appearance. Therefore, it is important to identify an architectural modular, to join an innovative architecture to an antiquated building to improve its thermal properties.
Keywords
Energy performance; Windows system; Comfort indoor; Natural ventilation; Experimental build- ings elements
MSJ765649_STROBE_Checklist – Supplemental material for Balance worsening associated with nabiximols in multiple sclerosis
No full textSupplemental material, MSJ765649_STROBE_Checklist for Balance worsening associated with nabiximols in multiple sclerosis by Letizia Castelli, Luca Prosperini and Carlo Pozzilli in Multiple Sclerosis Journal</p
MSJ765649_supplementary_tables – Supplemental material for Balance worsening associated with nabiximols in multiple sclerosis
No full textSupplemental material, MSJ765649_supplementary_tables for Balance worsening associated with nabiximols in multiple sclerosis by Letizia Castelli, Luca Prosperini and Carlo Pozzilli in Multiple Sclerosis Journal</p
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