1,720,961 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Molecular bases of Phosphodiesterase-4D inhibition by memory-enhancing GEBR-library compounds
Full text linkL’inibizione della famiglia di enzimi umani PDE4, espressi nei tessuti cerebrali e responsabili della regolazione dei livelli di adenosina monofosfato ciclico, è stata proposta come strategia per il trattamento di alcune patologie neurodegenerative ed infiammatorie. Negli ultimi anni, il design di composti che inibiscono selettivamente alcune isoforme di PDE4 è stato esplorato al fine di limitare l’insorgenza di effetti indesiderati, la cui causa è da ricercare in un approccio che mira ad inibire genericamente tutte le PDE4. La strategia più promettente al fine di ottenere una finestra terapeutica per malattie neurodegenerative, limitando al contempo gli effetti indesiderati, sembra essere lo sviluppo di inibitori dell’isoforma PDE4D. Infatti, la particolare importanza della PDE4D nello sviluppo della memoria e la sua associazione con i processi cognitivi, è stata dimostrata in topi knock-out. La GEBR-library, una famiglia di composti sviluppati per avere una finestra terapeutica simile, contiene molecole parzialmente specifiche per l’enzima PDE4D. Gli inibitori più importanti di questa libreria sono GEBR-7b e GEBR-32a. Questi, studiati in modelli murini, hanno prodotto effetti di miglioramento della memoria associata ai processi di riconoscimento di spazi ed oggetti, conseguentemente all'aumento dei livelli di cAMP nell'ippocampo.
Investigando sul comportamento biochimico di una selezione di molecole appartenenti alla libreria GEBR, sia dal punto di vista strutturale che funzionale, il lavoro si propone di studiarne il rapporto struttura-funzione, contribuendo alla caratterizzazione delle basi molecolari dell’inibizione dell’enzima PDE4D. Lo studio identifica interessanti proprietà strutturali, come l’esistenza di tre principali famiglie di composti che differiscono per le modalità di interazione con l’enzima. Tra queste, un gruppo di composti mostra una coda che si sviluppa verso la parte esterna della cavità catalitica, dove una possibile interazione con domini regolatori potrebbe in futuro essere sfruttata ed ottimizzata al fine di migliorare la potenza e la specificità del farmaco.The inhibition of human phosphodiesterase-4 (PDE4), an enzyme that is expressed in the brain and that is responsible for the regulation of the level of cyclic adenosine monophosphate (cAMP), has been proposed as a strategy for the treatment of several neurodegenerative and inflammatory pathologies. Over the last few years, the design of compounds that are selective for specific PDE4 isoforms has been explored as a way to limit the side effects that are associated with non-specific PDE4 inhibition. The design of PDE4D selective inhibitors is generally regarded as the most promising strategy to obtain a suitable therapeutic window for neurodegenerative pathologies and avoid side effects. Indeed, PDE4D has been demonstrated to be particularly important in memory development; its association with cognition processes has been demonstrated in knock-out mice, which have shown memory improvements similar to those shown by mice treated with Rolipram. In an effort to develop a drug that selectively targets the PDE4D isoforms without side effects, a number of compounds, commonly referred to as the GEBR library, that show partial selectivity for the PDE4D isoform have been synthesized. The reference inhibitors of the GEBR library are GEBR-7b and GEBR-32a, which have been shown to improve spatial and objects recognition memory and to increase hippocampal levels of cAMP in transgenic mice.
By addressing the biochemical behavior of a selection of GEBR-library compounds, both at the structural and at the functional level, we investigated their structure-function relationship and contribute to the elucidation of the molecular bases of PDE4 inhibition. Our characterization identified interesting structural properties, as well as three major families of compounds that differently dock inside the PDE4D catalytic pocket with different conformations: extended, twisted and protruding. Among them, the protruding compounds feature a tail that develops within the S-pocket, pointing towards the external part of the pocket, where a putative interaction with the regulatory UCR2 helix could in principle be exploited to increase drug potency and selectivity.DIPARTIMENTO DI CHIMICA, MATERIALI E INGEGNERIA CHIMICA "GIULIO NATTA"31MASI, MAURIZIOFRASSOLDATI, ALESSI
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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