197,414 research outputs found
Research on the combination of water and membranes as a structural building material
No full textp. 3024-3033The aim of this paper is to investigate the combination of water and membranes for
temporary architectural applications.
Water as a construction material, can be useful for three different purposes: first of all,
thanks to its thermal mass, it can be used as a medium for cooling down or heating up
buildings (Pronk et al [6]); secondly water is uncompressible and, in combination with air,
can be used as part of a structural element; thirdly the mass of water could work as a sound barrier so it can be used as sound insulation material (Rodrigues and Coutinho [7]).
This paper shows the result of the structural behaviour. There is another paper about sound insulation properties of water. The research in both structural and sound insulation fields was carried out in the laboratories of Technische Universiteit Eindhoven, The Netherlands.
The prototype is a "waterbeam" of 2 m span. Starting from the Tensairity(R) technology
principle (Luchsinger et al [8]) developed by Airlight, the purpose of this experiment is to
replace the iron struts with a second membrane chamber filled with water. Water works
well in compression and air prevents buckling. The result is a rigid structural element made by non-rigid material (water, air, membranes and cables) with a significant reduction of weight and cost of transportation compared to the traditional iron beam but also compared with the Tensairity(R) system. Different bending tests were carried out. In each test, the two chambers of the beam were filled with air or water to understand the material behaviour.The comparison between the results shows that water works slightly better than air (stiffness increase of a range of 8-13% in the elements filled with water).
Water application in architecture showed promising results. Further investigation (pure
compression tests on columns, multiple layers sound barrier) should be carried out. These results could give architects new design opportunities and solutions concerning temporary buildings and moveable architecture. Moreover the company and building construction industry could develop innovative structural elements and new insulation components.Pronk, A.; Maffei, R.; Martin, H. (2009). Research on the combination of water and membranes as a structural building material. Editorial Universitat Politècnica de València. https://riunet.upv.es/handle/10251/670
Development and implementation of an ICF-based e-intake tool in clinical otology and audiology practice: viewing the patient from a biopsychosocial perspective
No full textKramer, S.E. [Promotor]Goverts, S.T. [Copromotor]Merkus, P. [Copromotor]Pronk, M. [Copromotor
Jan Pronk over de voortgang van EBM
No full textAfgelopen studiejaar heeft het Instituut Bestuurskunde naast de reguliere BBO track de EBM track geïntroduceerd. Wij spreken Jan Pronk, grondlegger van deze nieuwe track, over hoe het er na het eerste half jaar voor staat
Research on the combination of water and membranes as sound insulation building material
No full textp. 3034-3040This research concerns a 200 mm thick panel filled with water. The airborne sound
insulation of this panel was measured in accordance with standard ISO 140-3 [2]. Results
show that the single number rating for the airborne sound insulation Rw [3] for an average water layer thickness of 200 mm is 48 dB. This value is comparable to the one of a 150 mm brick wall or 100 mm concrete panel. Predictions about sound insulation of the same system at different thickness and possible applications such as highway sound barrier or construction site sound barrier are presented in the following pagePronk, A.; Maffei, R.; Martin, H. (2009). Research on the combination of water and membranes as sound insulation building material. Editorial Universitat Politècnica de València. https://riunet.upv.es/handle/10251/670
Pronk Poppenhuis: Establishing and Destabilizing Agency Among Seventeenth-Century Burgher Wives in the Dutch Republic
No full textThis thesis shines novel light on the Dutch pronk poppenhuis, as a microcosm which models the simultaneously destabilization and establishment of agency among the Baroque burgher wives who commissioned them. Closely discussing seventeenth-century Dutch female ambitions, this article will explore the ways in which these housewives were both taught to behave appropriately in Dutch society and how they then displayed obedience to those values. I concurrently argue that the commissioning of and interaction with the pronk poppenhuis, particularly Pronk Poppenhuis De Patronella Dunois, simultaneously represents and perpetuates the growth of agency within the commissioner. This will be done through close inspection of the commissioner along with the wide variety of foreign and costly materials included in Pronk Poppenhuis de Patronella Dunois. Research conducted on still life paintings from the same period and region provide relevant supplemental evidence along with various other theories to address understudied elements of the dollhouse. This thesis provides vital encouragement to return to seventeenth-century Dutch artifacts, particularly those denoted as toys, in order to better understand larger social and cultural expectations and ambitions through microcosmic objects representing lived in spaces. Finally, this thesis provides a platform for further research into under-explored subjects of female agency in seventeenth-century Netherlands
Finite-size corrections to the free energies of crystalline solids
No full textWe analyze the finite-size corrections to the free energy of crystals with a fixed center of mass. When we explicitly correct for the leading (ln N/N) corrections, the remaining free energy is found to depend linearly on 1/N. Extrapolating to the thermodynamic limit (N → ∞), we estimate the free energy of a defect-free crystal of particles interacting through an r–12 potential. We also estimate the free energy of perfect hard-sphere crystal near coexistence: at ρσ3 = 1.0409, the excess free energy of a defect-free hard-sphere crystal is 5.918 89(4)kT per particle. This, however, is not the free energy of an equilibrium hard-sphere crystal. The presence of a finite concentration of vacancies results in a reduction of the free energy that is some two orders of magnitude larger than the present error estimate
Deltares/als2dtm: Archived version
No full text<p>All code required to create DTMs from raw .las or .laz files, used in Vernimmen, R., Hooijer, A., Yuherdha, A.T., Visser, M., Pronk, M., Eilander, D., Akmalia, R., Fitranatanegara, N., Mulyadi, D., Andreas, H., Ouellette, J., Hadley, W., 2019. Creating a lowland and peatland landscape DTM from interpolated partial coverage LiDAR data for Central Kalimantan and East Sumatra. Remote Sensing 11, 1152, <a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.org%2F10.3390%2Frs11101152&data=02%7C01%7C%7C931c0a4179da428c120c08d6d9be67e7%7C15f3fe0ed7124981bc7cfe949af215bb%7C0%7C0%7C636935809139113127&sdata=cPh9VZO27r8tKQvlX1%2BQL4gRsQeHFCrgXxU4PGgSp%2Fo%3D&reserved=0">https://doi.org/10.3390/rs11101152</a>.</p>
Old Church Slavonic (j)utro, Vedic uṣár- ‘daybreak, morning’
No full textDescriptive and Comparative Linguistic
Brain development in a dish
No full textThis thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole new fields of study and unprecedented possibilities of generating human cells in vitro. iPSCs have due to their pluripotent state the theoretical ability to be an unlimited source of cells, capable to generate any cell of the human body. They can be derived from somatic tissue and therefore used to generate disease specific cells.In paper I, we show the generation of disease specific neural stem cells from lissencephaly patients carrying a mutation in doublecortin (DCX). Lissencephaly is a disorder that affects cell migration, a phenotype we could replicate in our model. Furthermore, we show a defect in proper neurite outgrowth that we could rescue through the SLIT/ROBO pathway, and a prolonged proliferation. Together, showing the feasibility of using iPSC derived neural stem cells to model human neurodevelopmental disorders such as lissencephaly.In paper II we explored the role of p53 in neurodevelopment using both iPSC derived neuroepithelial stem cells (NES) and 3D brain organoids.Here we used lentiviral knockdown of tumor protein (TP53) in both the NES and iPSCs to follow neural development. We show the importance of p53 in maintaining genomic stability of NES cells and the involvement in maintaining the metabolic balance, resulting in lower expression of oxidative phosphorylation (OXPHOS) genes, shifting the cells to a more glycolytic state. Further differentiation into neurons showed an increased pace of differentiating. When placing p53 in the context of brain organoids, we show the reduction of TBR2+ intermediate progenitor cells (IPCs) and TBR1+ neurons. Analyzing metabolic gene profile also revealed the downregulation of OXPHOS related genes, indicating the regulation by p53 of the metabolism in brain organoids.In the manuscript, we explored amore metrological aspect for modeling neurodevelopmental diseases. By generating brain organoids and evaluating the neuronal activity we show the feasibility for future drug screening. Furthermore, we could perform an in vitro transplantation of NES cells and show their differentiation, making a small step towards an alternative for in vivo transplantation.In summary, this thesis shows some of the potential of in vitro brain development and the applications these brain models can be used for.List of scientific papersI. An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis. M Shahsavani, RJ Pronk, R Falk, M Lam, M Moslem, SB Linker, J Salma, K Day, J Schuster, B-M Anderlid, N Dahl, FH Gage, and A Falk. Molecular Psychiatry. https://doi.org/10.1038/mp.2017.175 II. p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Ana Marin Navarro#, Robin Johan Pronk#, Astrid Tjitske van der Geest, Ganna Oliynyk, Ann Nordgren, Marie Arsenian-Henriksson, Anna Falk, and Margareta Wilhelm. Cell Death and Disease. #Authors contributed equally. https://doi.org/10.1038/s41419-019-2208-7 III. Generation of a 2D and 3D System to Understand Neuropsychiatric Disorders. Pronk R.J., Hauger P.C., Marin Navarro A, Wilhelm M, and Falk A. [Manuscript]</p
Combining cognitive bias modification training with motivational support in alcohol dependent outpatients: study protocol for a randomized controlled trial
No full textBackground
Addiction research has hypothesised that automatic and reflective cognitive processes play an important role in the onset and maintenance of alcohol (ab)use, wherein automatic reactions to drug-related cues steer the drug user towards consuming before reflective processes can get over and steer towards a different behavioural response. These automatic processes include the tendency to attend and approach alcohol cues. These biases may be trained away from alcohol via computerised cognitive bias modification (CBM). The present protocol describes the design of a double-blind randomised controlled trial (RCT) testing the effectiveness of attentional bias and approach bias re-training with a 2×2 factorial design, alongside a brief motivational support (MS) program.
Methods/Design
Participants (n = 120) are adult alcohol dependent outpatients, recruited from a public health service for addiction in Italy, who have been abstinent for at least two months, and with a main diagnosis of alcohol dependence disorder. Participants are randomly assigned to one of four experimental conditions and complete 11 sessions of training after a baseline assessment. The MS takes place before each training session. Post-intervention and three-month follow-up assessments examine the change in clinical outcome variables and attentional and approach biases (measured with the Visual Probe Task and the Approach-Avoidance Task, respectively). Alcohol approach-avoidance implicit memory associations (measured with the Brief Implicit Association Test) are also evaluated at pre- and post-intervention to explore generalisation effects. Primary outcome measure is relapse rate at follow-up. Secondary outcome measures include change in cognitive biases, in alcohol-related implicit memory associations, and in the clinical variables assessed. An exploratory analysis is also planned to detect interaction effects between the CBM modules and possible moderators (interference control capacity, gender, age, number of previous detoxifications) and mediators (change in cognitive bias) of the primary outcome measure.
Discussion
This RCT is the first to test the effectiveness of a combined CBM intervention alongside motivational support in alcohol-dependent outpatients. The results of this study can be extremely valuable for future research in the optimisation of CBM treatment for alcohol addiction
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