1,720,968 research outputs found
Atypical femoral fracture as first sign of non-hodgkin lymphoma- case report with a brief review of the literature
No full textAtypical subtrochanteric and diaphyseal femoral fractures (AFF) have been suggested to be associated with the use of bisphosphonates (BPs), but the role of these drugs is still under debate. A 64-year old female, never treated with BPs was admitted to our Rehabilitation Institute because of a recent right AFF. The patient began suffering from low back pain radiating to the groin and to the anterior regions of the right thigh and leg, A nuclear magnetic resonance (NMR) of the lumbar spine showed disc protrusions at the L3-L4 and L5-S1 levels with impingement of the spinal nerve root. Therefore she was treated with analgesic, anti-inflammatory and muscle relaxing compounds for nine months without reduction of symptoms. Being the pain still present, the patient felt down the street breaking the right femoral neck and the femoral distal shaft. Following the ASBMR criteria the fracture was classified as a complete AFF and the patient underwent surgical ostheosynthesis with nail. A bone biopsy of the fracture site was performed showing findings consistent with B-cells non-Hodgkin lymphoma (NHL). Immuno-histochemical analysis highlighted that the atypical cells were follicolar G2 pattern diffuse large B cells
Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome
No full textBackground: Long-term nocturnal non-invasive mechanical ventilation (NIMV) is an
effective treatment for obesity-hypoventilation syndrome (OHS), improving central carbon
dioxide (CO2) sensitivity. Leptin might contribute to sustain adequate ventilation in
obesity. The aim of the study was to investigate the role of leptin in the OHS pathogenesis
looking at its relationship to CO2 sensitivity before and after NIMV in OHS patients.
Methods: In six obese patients (3F/3M; aged 6379 yr; BMI 47.074.5 kg/m2) with OHS and
without obstructive sleep apnoea–hypopnoea (OSAH) diurnal arterial blood gases, fasting
plasma leptin concentration and CO2 chemosensitivity were determined before and after
10.375.6 (range 6–20) months of NIMV.
Results: After NIMV improvements were observed in gas exchange (PaO2 from 51.376.7 to
75.0710.3 mmHg, po0.01; PaCO2 from 55.574.8 to 43.771.2 mmHg, po0.01; [HCO3 ]
from 33.373.8 to 29.871.7 mmol/l, po0.05) and CO2 chemosensitivity, measured as P0.1/
PetCO2 slope (from 0.0970.07 to 0.1870.07 cmH2O/mmHg, po0.05) and VE/PetCO2 slope
(from 0.470.3 to 0.970.5 l/min/mmHg, p1⁄4 0:07). Plasma leptin increased from
34.5721.1 ng/ml to 50.2722.9 ng/ml (po0.01) after NIMV and changes of the P0.1/
PetCO2 slope correlated with percent changes of plasma leptin (r2 1⁄4 0:79, po0.05).
Conclusions: These findings suggest a possible role of leptin in the recovery of
neuromuscular response to hypercapnia obtained during long-term nocturnal NIMV in
OHS patients without OSAH
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Increase prevalence of silent myocardial ischemia and severe ventricular arrhythmias in untreated patients with AD and MCI without overt coronary artery disease
No full textObjective: To assess the prevalence and the characteristics of silent myocardial ischaemia (SMI) and ventricular arrhythmias (VA) in subjects
with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and their relationships with QT interval dispersion (QTD).
Methods: Thirty-three subjects with AD, 39 subjects with MCI, and 29 cognitive healthy control subjects matched for demographic
characteristics, hypertensive condition, smoking habits, and laboratory parameters were enrolled. Each subject underwent clinical and cognitive
examination, a structural brain imaging study, electrocardiogram (ECG), 24-h ECG recording, 24-h blood pressure monitoring, and
echocardiogram.
Detection and characterization of QT dispersion, SMI and VA were performed.
Results: The three groups were comparable regarding demographic and basal cardiovascular characteristics: notwithstanding this, SMI
episodes were observed only in AD and MCI patients (19 and 14, respectively). A significantly greater prevalence of repetitive ventricular
premature beats was observed in AD (mean 8.56±13.1) and in MCI (1.8±7.2) vs. control (0.7±1.7). The QTD, the ischaemic burden and
the number of repetitive ventricular beats revealed to be significantly related.
Conclusions: Increased prevalence of SMI and potentially ominous VA were found in AD and, to a lesser extent, in MCI. SMI and repetitive
VA were significantly related with QTD. These findings could be related to an increased risk of sudden cardiac death in AD and MCI patients
- …
