1,720,996 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pathological mechanisms of autosomal recessive centronuclear myopathy
No full textBIN1 est une protéine qui tubule les membranes. Elle est composée de plusieurs domaines : un domaine BAR, qui lie les membranes et possède une propriété de tubulation; un motif PI qui lie les phophoinositides et est uniquement exprimé dans le muscle squelettique; un domaine CLAP qui lie la clathrin et AP2 et qui n'est présent que dans les isoformes de BIN1 exprimées dans le cerveau; un domaine MBD impliqué dans la liaison à c-Myc; et un domaine SH3 impliqué dans les interactions avec les protéines riches en prolines. BIN1 est une protéine ubiquitaire, et l'organe où elle est le plus fortement exprimée est le muscle squelettique. Il a été montré que des mutations dans l'amphiphysine 2/BIN1 causent une myopathie centronucléaire récessive (ARCNM, OMIM 255200). Les mutations trouvées chez les patients sont réparties dans tous les domaines de la protéine, et deux d'entre elles aboutissent à un codon stop prémature dans l'exon 20, dernier exon de la protéine. Le motif PI, codé par l'exon 11, est régulé positivement pendant la myogenèse. Le but de cette recherche était de mieux comprendre le rôle de BIN1 dans le muscle sain et dans le cas de myopathie centronucléaire. Nous avons donc utilisé la technique de recombinaison homologue ciblée dans les cellules ES pour générer deux lignées de souris knockout: BIN1 exon 11 (délétion de l'exon 11) et BIN1 exon 20 (délétion de l'exon 20). La délétion de l'exon 20 détruit le domaine SH3, qui permet l'interaction de BIN1 avec différentes protéines, dont la dynamine 2, et induit une baisse considérable de l'expression de BIN1 au niveau protéique. Les délétions totales et spécifiques du muscle de l'exon 20 provoquent une létalité périnatale. Nous avons observé une perturbation de l'organisation des tubules T chez les souris KO, ce qui montre l'importance de BIN1 pendant la biogenèse des tubules T. Cependant, l'induction de la délétion chez la souris adulte n'a affecté ni la fonction ni l'organisation du muscle. Pour comprendre le rôle du motif PI, qui est spécifique du muscle, nous avons caractérisé les souris BIN1 KO exon 11. Même à 12 mois, la fonction du muscle n'était pas compromise chez ces souris. En revanche, nous avons observé des problèmes de régénération du muscle squelettique. Ce travail révèle, qu'in vivo, BIN1 est nécessaire pour la biogenèse des tubules T, mais pas indispensable pour le maintien du muscle. D'autre part, le domaine PI, spécifique du muscle, est impliqué dans la régénération musculaire. Sa function dans les muscles est régulée finement par l’expression de différentes isoformes et par des interactions intra-moléculaires. Comprendre ces caractéristiques nous aiderait à développer de nouvelles thérapies pour les patients atteints de ARCNM et de MD.BIN1 is a membrane tubulating protein and it consists of the BAR domain which binds membranes and has tubulating property; the PI motif which binds phosphoinositides and is expressed only in skeletal muscle; the CLAP domain binds clathrin and AP2 and is present exclusively in brain isoforms of BIN1; the MBD is involved in c-Myc binding and the SH3 domain is involved in interactions with prolin-rich proteins. BIN1 is an ubiquitously expressed protein with the highest expression in skeletal muscle. Mutations in amphiphysin 2 / BIN1 were found to cause autosomal recessive centronuclear myopathy (ARCNM, OMIM 255200). Mutations in patients were found in all the protein domains and include two mutations leading to a premature stop codon in the last exon 20. The PI motive, encoded by exon 11, is upregulated during myogenesis. The aim of this research was to better understand the role of BIN1 in healthy muscle and in the pathology of CNM. For this purpose, by using targeted homologous recombination in ES cells, we generated two knockout mouse models: BIN1 exon 11 and BIN1 exon 20, with exon 11 and 20 deleted, respectively. The deletion of exon 20 disrupts the SH3 domain, involved in interactions with different proteins, amongst which is dynamin 2 and induced a considerable loss of the total BIN1 protein expression. The total and muscle specific deletions of exon 20 were perinatally lethal. A disrupted T-tubules organization was observed in knockout mice, showing an importance of BIN1 during the T-tubule biogenesis. Interestingly, deletion induced in adult mice did not affect muscle function and organization. In order to understand the role of the muscle specific PI motif, we characterized the BIN1 exon 11 KO mice. Even at 12 months of age the muscle function in mice was not compromised by this deletion. However, further examination showed impairment of skeletal muscle regeneration. This work revealed that in vivo, BIN1 is necessary during the T-tubules biogenesis and dispensable for muscle maintenance, whereas the skeletal muscle specific PI motif of BIN1 is involved in muscle regeneration. Its function in muscle is tightly regulated by isoform switch and intramolecular binding. Understanding these features will help us step forward towards successful therapy in ARCNM and MD patients
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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