1,721,276 research outputs found
Evolving concepts in atrial fibrillation epidemiology: Advancing knowledge about cardiovascular health in sub-Saharan Africa
No full textAtrial fibrillation (AF) is the most common cardiac arrhythmia presenting in the daily clinical practice [1]. In the last 50 years, AF prev- alence and incidence have been shown to constantly increase, progres- sively becoming a worldwide healthcare issue, with relevant public health expenditure, both in terms of clinical management and conse- quences related to the main clinical adverse events related to AF (i.e. stroke, major bleeding, cardiovascular events) [1,2]
Atrial fibrillation as a clinical model of multimorbidity: current evidence, experimental data and a proposal for management
Full text linkLa Fibrillazione Atrial (FA) rappresenta una delle più diffuse aritmie cardiache nella popolazione generale. Nel corso degli ultimi anni, è emerso in maniera sempre più rilevante come i pazienti con FA siano ad elevato rischio di eventi cardiovascolari e morte, oltre che di eventi tromboembolici. Il rischio di morte e morte cardiovascolare è associato indipendentemente con diverse comorbidità sia cardiovascolari che non. Il concetto di multimorbidità è diventato di grande attualità nella valutazione clinica, soprattutto dei pazienti anziani. Attraverso l'analisi di cinque differenti corti di pazienti con FA (retrospettivo, RCT, European-wide, pazienti anziani ospedalizzati) si è potuto mettere in evidenza come esista uno stretto rapporto tra FA e multimorbidità e come nei pazienti con FA la multimorbidità sia in grado di influenza la gestione, l'andamento clinico e soprattutto il rischio di eventi clinici maggiori. L'uso di strategie integrate che contemplino la valutazione della multimorbidità da parte di medici, come l'internista, capaci di gestire accuratamente la multimorbidità, sono raccomandate al fine di ottenere una significativa riduzione del rischio di eventi clinici
The dangerous combination of atrial fibrillation and hypertension: An urgent need to handle complexity
No full textThe Recognizability of a Place Through Generative Representation of Intangible Qualities
No full textThe recent advancements in artificial intelligence (AI) platforms dedicated to image generation have revolutionized conceptual design across various creative disciplines, including architectural design. We are witnessing a growing integration of AI within this field, a phenomenon fuelled by its remarkable advantages and the ongoing evolution of application methods. This rapid adoption rate is primarily motivated by AI’s ability to enhance the productivity of architects and designers, providing them with a fast and effective tool for image generation
Impact of Frailty Dynamics in Patients With Atrial Fibrillation: Learning How Clinical Complexity Increases Risk in Cardiovascular Diseases
No full text
The Architecture of the Virtual Not-Place. Reflections on Design in the Metaverse
No full textThe development of new technologies in the context of the ‘Metaverse’ necessitates an in-depth reflection on the perception of space in the design of virtual environments. This article examines the importance of the concept of ‘presence’ and refers to Marc Augé’s work on the distinction between ‘places’ and ‘not-places’. It updates the same concept to virtual worlds and the design of architecture in the Metaverse. The absence of design control results in transit experiences that are more akin to virtual ‘not-places’, which in turn leads to a loss of a sense of community among users. Consequently, it is imperative for architecture in the Metaverse to address these issues, commencing with a critique of the concept of aesthetic and functional ‘skeuomorphism’. The design and modelling of architectural environments within the metaverse, conceived as virtual spaces, plays a pivotal role. The objective of this article is to stimulate reflections on the formulation of graphic codes to be used in the future design of virtual environments
Simple decision-making between a vitamin K antagonist and a non-vitamin K antagonist oral anticoagulant: using the SAMe-TT2R2score
Full text linkStroke prevention with oral anticoagulation (OAC) is central to the modern management of atrial fibrillation (AF) patients.1 For many years, vitamin K antagonists (VKAs, e.g. warfarin) have been the default class of OAC, but we now recognize that it is not simply prescribing VKA but very close attention to quality of anticoagulation control is necessary, as reflected by the individual time in therapeutic range (TTR).2 An average individual TTR of >70% is recommended to maximize efficacy and safety of the VKAs.2,3
Nonetheless, the VKAs have significant inter- and intra-patient variability, partly from diet and drug interactions, thus necessitating regular international normalised ratio (INR) monitoring.2 More recently, we have had the non-VKA oral anticoagulants (NOACs, previously referred to as new or novel OACs4) available, which offer efficacy, safety, and relative convenience compared with the VKAs, for stroke prevention in AF
Use of NOACs in the Perioperative Management of Patients with Atrial Fibrillation::To Stop, Bridge or Continue?
Full text linkOver the last decade, the availability of non-vitamin K antago- nist oral anticoagulants (NOACs) has significantly changed the daily clinical practice in managing thromboembolic risk in patients with atrial fibrillation (AF).1 Guidelines for AF man- agement have established that NOACs are the preferred treat- ment for the majority of AF patients;2 however, recent data from ‘real-life’ registries clearly show that a significant pro- portion of patients are still treated with vitamin K antago- nists.3–8 Nevertheless, the role of NOACs still seems to be debated in some specific circumstances, such as their role in the peri-operative management of patients with AF, in relation to interruption or continuation of anticoagulation
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