1,721,238 research outputs found
The application of cancer stem cell model in malignant mesothelioma
No full text: The high mortality rate of malignant pleural mesothelioma led to study the mechanisms for chemoresistance. The cancer stem cell (CSC) model has been proposed to explain chemoresistance. CSCs are characterized by self-renewal capacity, that is detected through tumor-initiating cell assays. As in other malignancies, many studies sought to identify surface markers to isolate CSCs from malignant mesothelioma. Other studies characterized malignant mesothelioma CSCs for the expression of specific genes involved in stemness and the expression of proteins involved in chemoresistance. However, the main methods to characterize isolated CSCs include sphere formation, invasiveness, tumor-initiating capacity and expression of specific surface markers. The better knowledge of malignant mesothelioma CSCs allowed exploring new potential targets to develop specific treatments
New aspects on the role of lipoxygenases in cancer progression
Full text linkThe Lipoxygenases (LOXs) are a class of
enzymes that convert arachidonic, linoleic, and other
polyunsaturated fatty acid into biologically active
metabolites involved in the inflammatory and immune
responses. Recent evidences indicate that LOXs and the
signaling pathways that are involved in their activation
are also important for carcinogenesis and tumor
progression. LOXs should therefore receive as much
attention from cancer researchers as it has already from
immunologists. In this article, we will review some
evidence that the LOXs pathways affect several aspects
of lung, pancreatic and prostate cancer progression.
Moreover, we discuss how this new perspective on the
roles of LOXs and their metabolites can have important
implications to cancer therapy
Circulating microRNAs (miRs) for diagnosing acute myocardial infarction: An exciting challenge.
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Noncytotoxic functions of natural killer (NK) cells: large granular lymphocytes (LGL) produce a B cell growth factor (BCGF).
No full textExperimental therapy of malignant mesothelioma: new perspectives from anti-angiogenic treatments
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