1,354,284 research outputs found
The Italian Implantable Cardioverter-Defibrillator Registry. A survey of the national activity during the years 2001-2003
No full textBACKGROUND:
In recent years several trials demonstrated the efficacy of implantable cardioverter-defibrillator (ICD) therapy for sudden cardiac death prevention and total mortality reduction in particular high-risk groups of patients. The aim of this review was to report the main epidemiological data and the most important clinical characteristics of patients enrolled in the Italian ICD Registry in the years 2001-2003.
METHODS:
The Italian ICD Registry--official member of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC)--collects 85% of the data concerning the national ICD implantation activity, based on the European Implantable Defibrillator form (EURID). Data are validated for quality of information and uniqueness at the moment of data entry and in successive steps at the time of the annual analysis.
RESULTS:
The number of ICDs implanted in Italy has been continuing to increase during the last years according to the general trend in European and non-European countries: 2400 in the year 2001, 3934 in the year 2002, and 5318 in the year 2003. The number of ICDs per million of inhabitants in Italy was 42.1 in the year 2001 (+11.8% with respect to 2000), 69.0 in the year 2002 (+63.9% with respect to 2001), and 93.3 in the year 2003 (+35.2% with respect to 2002). The number of implanting centers increased progressively from 273 in the year 2001 to 304 in the year 2002, and 340 in the year 2003. The median age of patients treated with ICD implantation was 67 years in the years 2001-2002, 68 years in the year 2003. The prevalence of male patients was significantly higher (79.3% in 2001, 82.3% in 2002, and 81.4% in 2003). The main indication was syncope (25.5, 29.3, and 32.9% in the years 2001, 2002, and 2003, respectively), followed by palpitations (17.7, 18.5, and 16.4% in the years 2001, 2002, and 2003, respectively), and cardiac arrest (10.0, 13.1, and 16.5% in the years 2001, 2002, and 2003, respectively). The use of ICD in patients considered at risk but without history of sustained ventricular tachycardia had a 3-fold increase during the 3 years, from 6.4% in 2001 to 18.2% in 2003. Ventricular tachycardia was the main arrhythmia in 50.4 to 55.0% of cases, ventricular fibrillation in 13.5 to 18.1%, both in 4.1 to 6.5%. The vast majority of patients presented at the enrolment either a mild or severe reduction in ejection fraction (30 to 50%, < 30%). Amiodarone was administered alone or in combination with antiarrhythmics in 29.7 to 40.0% of patients. Single-chamber ICDs were implanted in the years 2002 and 2003 in 45.7 and 39.2% of patients, dual-chamber ICDs in 34.9 and 32.4%, biventricular ICDs in 19.4 and 28.4%, respectively.
CONCLUSIONS:
The ICD implantation rate in Italy increased significantly in the period 2001-2003, similarly to the trend in the other western countries and following the publication of controlled studies in the field of primary and secondary prevention of sudden cardiac death. The Italian ICD Registry showed during the last 3 years an important increase in prophylactic ICD utilization. A sophisticated ICD, including dual-chamber pacing or cardiac resynchronization therapy, was chosen in a high percentage of patients
Scrittori e giornalismo. Sondaggi sul Novecento letterario italiano, Nuova edizione, con due testimonianze di Vittorio Emiliani e Anna Proclemer
No full textIl volume contiene alcuni risultati di un «Progetto giovani ricercatori» svolto presso l’Università di Macerata e coordinato da Marco Dondero.
Lo scopo del progetto non era offrire un quadro d’insieme, una mappa esaustiva del rapporto fra letteratura e giornalismo in Italia; era invece proporre alcune indagini più ravvicinate e puntuali che potessero precisare, definire, forse talvolta modificare il panorama generale sull’argomento che diversi studi precedenti avevano già tratteggiato, ma solo a grandi linee. Il programma della ricerca è stato dunque quello di estendere le conoscenze specifiche riguardo alla collaborazione a giornali e riviste di alcuni significativi autori del Novecento, e di analizzare l’influenza di tale collaborazione sui loro scritti creativi.
Gli scrittori analizzati nei vari saggi sono Gabriele D’Annunzio, Leo Ferrero, Cesare Pavese, Vitaliano Brancati, Carlo Levi e Tiziano Terzani; cronologicamente, si parte dagli anni Ottanta dell’Ottocento per arrivare ai primi anni del Duemila; i punti di vista con cui si è analizzato il tema, infine, sono diversi: si va dalla considerazione dell’intera esperienza di un giornalista-scrittore all’indagine sulla collaborazione di alcuni autori a singole testate, all’analisi della trasposizione romanzesca di reali esperienze giornalistiche, fino allo studio delle varianti fra testi pubblicati sia in riviste sia in volumi.
La nuova edizione è arricchita di due preziose testimonianze: di Vittorio Emiliani su Terzani e di Anna Proclemer su Brancati
Impact of the main implantable cardioverter-defibrillator trials for primary and secondary prevention in Italy: A survey of the national activity during the years 2001-2004
No full textBackground: Several trials demonstrated the lifesaving role of implantable cardioverter-defibrillator (ICD) in high-risk groups of patients. Aim of this review was to report the clinical characteristics of patients enrolled in the ICD Registry of the Italian Association of Arrhythmology (AIAC) in the years 2001-2004. Methods: The Registry collects prospectively 85% of national ICD implantation activity on the basis of European ICD form (EURID). Results: The number of implanted ICDs in Italy was 2,418 in the year 2001, 3,992 in the year 2002, 5,595 in the year 2003, and 7,190 in the year 2004. The number of ICDs per million of inhabitants was 42.1 in the year 2001 (+11.8% respect to 2000), 70.0 in the year 2002 (+65.1% respect to 2001), 98.3 in the year 2003 (+40.4% respect to 2002), and 125.0 in the year 2004 (+27.2% respect to 2003). The median age was 67 years in the years 2001-2002, 68 years in the years 2003-2004. The main indications during the study were syncope (24.2-14.9%) and ..
The use of implantable cardioverter-defibrillators in patients with hypertrophic and arrhythmogenic right ventricular cardiomyopathy. A large national database
No full textEARLY REPOLARIZATION IN TIME: COMPARISON OF THE EARLY REPOLARIZATION PATTERN BETWEEN ADULT AND PEDIATRIC POPULATION
No full textThe Daphne study: a randomised trial to test the combined role of drugs and dedicated device to prevent and treat atrial tachyarrhythmias
No full textLong-term outcome of 'super-responder' patients to cardiac resynchronization therapy.
No full textAIMS: To evaluate the long-term changes of clinical and echocardiographic parameters, the incidence of cardiac events and parameters associated with late cardiac events in 'super-responders' to cardiac resynchronization therapy (CRT) with [CRT defibrillator (CRT-D)] or without defibrillator back-up.
METHODS AND RESULTS: In all consecutive patients treated with CRT in two Italian centres (Trieste and Udine) with left ventricular ejection fraction (LVEF) ≤0.35 at implantation (Timp) and LVEF > 0.50 1 and/or 2 years (Tnorm) after implantation, the long-term outcome and the evolution of echocardiographic parameters were assessed; factors associated with a higher risk of cardiac events, defined as hospitalization or death for heart failure (HF), sudden death, or CRT-D appropriate interventions, were also analysed. Among the 259 patients evaluated, 62 (24%) had LVEF ≥ 0.50 at Tnorm (n = 44 with at 1 year, n = 18 at 2 years). During a mean follow-up of 68 ± 30 months, one cardiac death (for HF) and eight cardiovascular events (two hospitalization for HF and six appropriate CRT-D interventions) occurred. At the last echo evaluation (Tfup) performed 51 ± 26 months after Timp, LVEF was 0.45 in four of them). At univariable analysis, only LV end-systolic volume evaluated at Tfup was associated with a higher risk of cardiac events during follow-up.
CONCLUSION: In 'super-responders' to CRT long-term outcome is excellent. However, cardiac events, mainly CRT-D appropriate interventions, can occur despite the persistence of LVEF > 0.50. Early identification of these patients is still an unsolved issu
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Current European practice in post MI patients: interim analysis of the first 804 patients enrolled in a multicentre registry
No full textThe role of implantable cardioverter defibrillator for primary vs secondary prevention of sudden death in patients with idiopathic dilated cardiomyopathy.
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