646 research outputs found
Understanding the role of membrane cholesterol upon Epstein Barr virus infection in astroglial cells.
No full textBackground: EBV infection has long been postulated to trigger multiple sclerosis (MS) and anti-EBV antibodies showed a consistent presence in MS patients. Previous reports from our group have shown that the EBV infects different brain cells. Entry of the virus in neuronal cells is assisted by several host factors including membrane cholesterol. By using an inhibitor, methyl-β-cyclodextrin (MβCD), we evaluated the role of membrane cholesterol in EBV infection and pathogenesis.
Methodology: The membrane cholesterol depleted cells were infected with EBV and its latent genes expression were assessed. Further, EBV-mediated downstream signalling molecules namely STAT3, RIP, NF-kB and TNF-α levels was checked at protein level along with spatial (periphery and nucleus) and temporal changes in biomolecular fingerprints with Raman microspectroscopy (RS).
Results: Upon treatment with MβCD, lmp1 and lmp2a suggested significant downregulation compared to EBV infection. Downstream molecules like STAT3 and RIP, exhibited a decrease in protein levels temporally upon exposure to MβCD while NF-kB levels were found to be increased. Further, the intensity of the Raman spectra exhibited an increase in triglycerides and fatty acids in the cytoplasm of EBV-infected LN-229 cells compared to MβCD+EBV. Likewise, the Raman peak width of cholesterol, lipid and fatty acids were found to be reduced in EBV-infected samples indicates elevation in the cholesterol specific moieties. In contrast, an opposite pattern was observed in the nucleus. Moreover, the ingenuity pathway analysis revealed protein molecules such as VLDLR, MBP and APP that are associated with altered profile of cholesterol, fatty acids and triglycerides with infection-related CNS disorders.
Conclusion: Taken together, our results underline the important role of membrane cholesterol over EBV entry/pathogenesis in astroglia cells which further trigger/exacerbate virus-associated neuropathologies. These results likely to aid into the prognosis of neurological disease like MS
A panoramic view of motherhood by juxtaposing the select trilogies of Flora Nwapa and Perumal Murugan
Get PDF<p>This article by Vimala Johnshi Rani compares the portrayal of motherhood in the works of African writer Flora Nwapa and Indian writer Perumal Murugan. By examining trilogies by each author, Rani explores how women in post-colonial South Africa and India navigate societal expectations and personal desires.</p>
Social Media in Tourism A Double Edged Sword
No full textExtensive spread of the Internet and speedy technological advancement have revolutionized all industries in the World specifically tourism. The presence of the information and communication technology have fundamentally change the way how tourists collect detailed information, how do they can carefully map decision substitutes, how they book their travel and how they share their unique travel experience with others. A vital step forward in the progress of the internet has been made by a noteworthy growth in the popularity of social media platforms. Social media plays a very important role in tourism which is an information based industry. Consumers need information that can assist them in the process of travel planning and making decisions related to selection of tourism destination and other travel related products. Social media has also extended the reach of industry as now they can easily target consumers sitting far away without even meeting them. Destination marketer use social media before the travel so as to engage and inform the tourists, during the travel so as to facilitate at destination and after the travel to remember and share experiences. But social media in tourism marketing can be both an aid and a threat as social media influences the tourism industry both in positive and negative ways, as the decisions of prospective travellers have been strongly affected by comments and personal experiences of other users on social media. The main objective of the paper is to understand the relationship between social media and destination marketing and to examine the positive and negative impact of social media marketing in tourism industry. Ms. Priyanka Sharma | Mr. Ravi Kumar | Ms. Asha Rani "Social Media in Tourism- A Double-Edged Sword" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-1 , December 2017, URL: https://www.ijtsrd.com/papers/ijtsrd8222.pd
Introduction: Why is philosophy relevant for clinical practice?
No full textThis book is intended as an intellectual resource for clinicians and healthcare professionals who are interested in digging deeper into the philosophical foundations of their daily practice. It is a tool for understanding some of the philosophical motivations and rationality behind the way medicine and healthcare are studied, evaluated and practiced. In particular, this book illustrates the impact that our thinking about causality, both philosophically and conceptually, has on the clinical encounter. The aim is to engage and empower healthcare professionals to take part in changing and defining the premises for their own practice. After all, if clinical decisions should be based on evidence, this ought to be evidence that is relevant and well-suited for the clinic. The book has two parts, Philosophical Framework and Application to the Clinic. The first part is written from the philosophical perspective and presents a singular overall framework. The second part is written primarily by clinicians who address some implications of the philosophical framework for different aspects of their own practice.Ethics & Philosophy of Technolog
Conclusion: Causehealth recommendations for making causal evidence clinically relevant and informed
No full textFrom the philosophical perspective presented in the first part of this book, together with the clinical application of this framework in the second part, it follows that we must change the way we approach causal evidence of health and illness conceptually, methodologically and practically. This has some practical consequences for the clinical encounter, as discussed throughout the book. We here offer some specific CauseHealth recommendations for making causal evidence more clinically relevant and better informed by the clinical encounter. The recommendations follow from an overall consideration of the previous chapters, both the philosophical framework and its clinical implications.Ethics & Philosophy of Technolog
Nuevos datos sobre el verdadero autor de «La Rani-ratiguerra» (1790), en la correspondencia del conde de Lumiares
Get PDFRESUMENEn la correspondencia que, entre 1773 y 1778, mantuvo Antonio Valcárcel Pío de Saboya, conde de Lumiares, con el ilustrado Gregorio Mayans y con el anticuario gaditano Antonio Mosti, se contienen ciertas manifestaciones relativas a una poesía manuscrita inédita que Valcárcel tenía intención de publicar de forma anónima pese a saber que su autor era el jesuita Martín Marín. El texto de dicho poema, conservado hoy en la Biblioteca Estense Universitaria de Módena, evidencia que se trata de la misma obra que en 1790 apareció publicada anónimamente en Valencia con el nombre de «La Raniratiguerra», y cuya autoría se atribuyó, bien entrado ya el siglo XIX, al dramaturgo José March Borrás; una atribución que ha perdurado hasta hoy y que debe ser objeto de revisión a la luz de los testimonios aportados por Valcárcel en su correspondencia.PALABRAS CLAVEConde de Lumiares, correspondencia, Batracomiomaquia, Rani-ratiguerra, José March Borrás, Martín Marín. TITLENew data about the true author of «La Rani-ratiguerra» (1790), in the correspondence of the count of Lumiares.ABSTRACTIn the correspondence maintained between 1773 and 1778 by Antonio Valcárcel Pío de Saboya, count of Lumiares, with the illustrated Gregorio Mayans and the antiquarian Antonio Mosti, there are certain manifestations related to an unpublished manuscript poetry that Valcárcel intended to publish anonymously despite knowing that its author was the jesuit Martín Marín. The text of this poem, preserved today in the Estense University Library of Modena, shows that it is the same poem that in 1790 was published anonymously in Valencia under the name of «La Rani-ratiguerra», whose authorship was attributed in the nineteenth century to the playwright José March Borrás; an attribution that has lasted until today and that must be object of revision in the light of the testimonies contributed by Valcárcel in his correspondence.KEY WORDSCount of Lumiares; correspondence, Batracomiomaquia, Rani-ratiguerra; José March Borrás, Martín Marín
Description of the Meaning of the Text and the Function of the Three Chants in the Rani Work Ceremony at GBKP (Batak Karo Protestant Church) Runggun Tiga Juhar, STM Hulu District, Deli Serdang District
No full textThis paper discusses three songs in the rani work ceremony at GBKP Runggun Tiga Juhar, STM Hulu sub-district, Deli Serdang Regency. Kerja rani is one of the ceremonies held on cultural week at GBKP Runggun Tiga Juhar. The rani work ceremony is one of the sources of church finances by collecting offerings and then conducting an auction. Some of the songs used in the rani work ceremony are Sendah kerja rani, Mbuah page, and Mejuah-juah. Sendah kerja rani is a song that must be sung because it is directly related to agriculture in the Karo tribe. While the other two songs, namely the songs Mbuah page and Mejuah-juah are taken from folk songs created by Djaga depari. This research aims to analyze the meaning of the text and the musical function of the three rani work ceremony songs. In answering the research objectives, the author uses the method of field work and desk work proposed by Bruno Netll. The theory used to answer the main problem in this paper is the semiotic theory pioneered by Roland Barthes, especially the meaning of denotation and connotation. The results of the study revealed that the rani work ceremony at GBKP Runggun Tiga Juhar is one way for the church to maintain culture and liven up the atmosphere of the ceremony. The three songs in the rani work ceremony have the process of the ceremony, the meaning of the text and its functions. It can be concluded that the rani work ceremony still continues by using the rani songs.100 PagesSkripsi Sarjan
Isolation and Identification of Lactic Acid Bacteria with Antimicrobial Activity from Different Food Sources
No full textHuman genetic factors associated with pneumonia risk, a cue for COVID-19 susceptibility
Get PDFPneumonia, an acute respiratory tract infection, is one of the major causes of mortality worldwide. Depending on the site of acquisition, pneumonia can be community acquired pneumonia (CAP) or nosocomial pneumonia (NP). The risk of pneumonia, is partially driven by host genetics. CYP1A1 is a widely studied pulmonary CYP family gene primarily expressed in peripheral airway epithelium. The CYP1A1 genetic variants, included in this study, alter the gene activity and are known to contribute in lung inflammation, which may cause pneumonia pathogenesis. In this study, we performed a meta-analysis to establish the possible contribution of CYP1A1 gene, and its three variants (rs2606345, rs1048943 and rs4646903) towards the genetic etiology of pneumonia risk. Using PRISMA guidelines, we systematically reviewed and meta-analysed case-control studies, evaluating risk of pneumonia in patients carrying the risk alleles of CYP1A1 variants. Heterogeneity across the studies was evaluated using I2 statistics. Based on heterogeneity, a random-effect (using maximum likelihood) or fixed-effect (using inverse variance) model was applied to estimate the effect size. Pooled odds ratio (OR) was calculated to estimate the overall effect of the risk allele association with pneumonia susceptibility. Egger's regression test and funnel plot were used to assess publication bias. Subgroup analysis was performed based on pneumonia type (CAP and NP), population, as well as age group. A total of ten articles were identified as eligible studies, which included 3049 cases and 2249 healthy controls. The meta-analysis findings revealed CYP1A1 variants, rs2606345 [T vs G; OR = 1.12 (0.75–1.50); p = 0.02; I2 = 84.89%], and rs1048943 [G vs T; OR = 1.19 (0.76–1.61); p = 0.02; I2 = 0.00%] as risk markers whereas rs4646903 showed no statistical significance for susceptibility to pneumonia. On subgroup analysis, both the genetic variants showed significant association with CAP but not with NP. We additionally performed a spatial analysis to identify the key factors possibly explaining the variability across countries in the prevalence of the coronavirus disease 2019 (COVID-19), a viral pneumonia. We observed a significant association between the risk allele of rs2606345 and rs1048943, with a higher COVID-19 prevalence worldwide, providing us important links in understanding the variability in COVID-19 prevalence
Povijest znanosti i prirodne filozofije u Hrvata (s osobitim obzirom na egzaktne znanosti) Knjiga III Rani novi vijek
Get PDFThis volume (The Early Modern Period) is the third part of The History of Science and Natural Philosophy among the Croats (with particular reference to the exact sciences) by academician Žarko Dadić. The first two volumes were The Middle Ages (2015) and The Renaissance (2016). Volume I covered the Middle Ages up to 1526, and Volume II the period from 1526 to the end of the sixteenth century. The third part covers events from 1600 to 1699. According to the author, “the 17th century, though considered part of late medieval times, can also be identified as the Early Modern Age. In philosophical and scientific terms, it was a particular age which differed from the Renaissance and in which the foundations of completely new philosophical and scientific attitudes were laid”. (page 8)Knjiga Rani novi vijek treći je dio cjeline Povijest znanosti i prirodne filozofije u Hrvata (s osobitim obzirom na egzaktne znanosti) autora akademika Žarka Dadića. Prethodno su objavljene dvije knjige: Srednji vijek 2015. i Renesansa 2016. godine. U knjizi koja se bavi srednjim vijekom obrađeno je razdoblje do 1526. godine, a u drugoj knjizi obrađeno je razdoblje od 1526. do kraja 16. stoljeća. Rani novi vijek pak obrađuje događaje od 1600. do 1699. godine. Naime, „Razdoblje 17. stoljeća je usprkos činjenici da je samo dio novog srednjeg vijeka označeno kao rani novi vijek. To je razdoblje u filozofskom i znanstvenom pogledu posebna cjelina različita od renesanse i u njemu se stvaraju temelji potpuno novih filozofskih i znanstvenih stavova).“ (str. 8
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