1,720,995 research outputs found
Nonlinear analysis for progressive collapse investigation on reinforced concrete framed structures
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Thirty-five patients with diagnosis of Axis II disorder and temperamental profile, in concurrent major depressive episode: response to short-time treatment with serotoninergic antidepressants
No full textAIM: The aim of this study was to identify individual characteristics that might influence response to treatment in patients with a depressive episode.
METHODS: Participants were interviewed using a structured clinical interview for DSM-IV Axis II (SCID-II, version 2.0) disorders, and the Italian version of Akiskal’s semi-structured clinical interview for temperamental profiles (TEMPS-I). A short-time (3 weeks) treatment with antidepressants (SSRI in therapeutic range: fluoxetine 20-80 mg/die, paroxetine 20-50 mg/die and citalopram 20-40 mg/die) is accompanied by careful monitoring of symptoms using the 21 items HAM-D scale (Hamilton Rating Scale for Depression).
RESULTS: An analysis of the mean HAM-D score of our sample underlined the highest values for histrionic personality, at baseline and at all treatment intervals compared to other personality disorders, corresponding to a weaker response to treatment in terms of reduction of depressive symptoms. Moreover, the patients with an irritable temperament presented a significantly higher mean HAM-D score at baseline and at all treatment intervals respect to other temperamental traits with a lower responsiveness to SSRI. Instead there was a statistically significant effect on the mean score obtained by the HAM-D at the third week in relation to the psychopathological characteristics of the sample. This indicated a poorer improvement in depressive symptoms with decreasing age at onset of depressive symptoms, age at first psychiatric contact and age at first hospitalization.
CONCLUSION: The identification of individual characteristics that might influence response to treatment in patients with a depressive episode may be extremely useful
Nor-clozapine Plasma Concentration/daily Clozapine Dose Ratio (Ncz/d): an Index of Response to Clozapine Treatment
No full textThe present study investigated relationships between plasma concentrations of clozapine (CZ) and nor-clozapine (NCZ), clozapine metabolic index (NCZ/CZ), nor-clozapine plasma concentration/daily clozapine dose ratio (NCZ/D) and response to clozapine treatment in schizophrenic patients. Twelve treatment-resistant schizophrenic patients, recruited for this study, were treated with clozapine for six weeks.
Our sample was composed by 4 males and 8 females aged 35-52 years recruited at the Department of Psychiatry, University of Naples SUN. The diagnosis of schizophrenia was established according to ICD-10 criteria (9 paranoid type and 3 residual type) and with history of illness from more than ten years, resistant to treatments with other typical and atypical antipsychotics. All the patients in this study were treated with clozapine, valproic acid, lorazepam or delorazepam.
Patient health improvement was assessed before (T0) and after six weeks of clozapine therapy (T6), using the Brief Psychiatric Rating Scale (BPRS). Plasmatic clozapine and nor-clozapine concentrations were determined by high-performance liquid chromatography (HPLC).
Analyses of variance (ANOVA) and χ2 -test (SPSS 19) were used to find correlations between the different studied parameters and the BPRS scores. No significant correlations between CZ, NCZ, NCZ/CZ and clinical health improvement in BPRS scores among our schizophrenic patients were found; however, a significant correlation (p<.0012) was observed between NCZ/D and clinical response to clozapine treatment in our sample
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Discrasie ematiche transitorie e persistenti indotte dalla clozapina durante le prime diciotto settimane di trattamento
No full textSCOPO
Le discrasie ematiche, tranne l’agranulocitosi, hanno ricevuto scarsa attenzione nei pazienti trattati con clozapina.
MATERIALI E METODI
Lo studio si è proposto di far luce su incidenza e decorso delle discrasie ematiche che si verificano durante le
prime diciotto settimane di trattamento con clozapina. Le discrasie sono state caratterizzate in base a diverse
variabili (sesso del paziente, età, numero di ricoveri precedenti, tempo di comparsa e scomparsa, dose di clozapina
quando appare la discrasia e alla fine della diciottesima settimana di trattamento, farmaci utilizzati prima
e in concomitanza al trattamento con clozapina, correlazione con la risposta clinica). Lo studio ha incluso 135
pazienti (M 75, F60), età media 33,1±10.4 anni. L’88.1% presentava discrasie ematiche, che sono state suddivise,
in base alla loro durata in transitorie e persistenti.
RISULTATI
I dati hanno rilevato che le discrasie persistenti hanno mostrato incidenza più alta (56.2%) rispetto a quelle
transitorie (11%), tra queste l’anemia persistente era più comune nelle donne (52.5% nelle F, 11.2% nei M)
mentre i maschi hanno presentato maggiore frequenza di eosinofilia (26.2% nei M, 21.2% nelle F), neutrofilia
(18.7% nei M, 15.0% nelle F) e leucocitosi (21.2% nei M, 8.7% nelle F). Le relazioni tra risposta clinica e discrasie
ematiche hanno rivelato correlazione positiva per i pazienti di sesso maschile con eosinofilia (p<.05)
e correlazione negativa per i pazienti di sesso maschile che hanno presentato leucocitosi persistente (p<.05).
CONCLUSIONE
I nostri dati mostrano che oltre all’agranulocitosi, vi sono diverse complicanze ematologiche comuni nei pazienti
trattati con clozapina
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
CLOZAPINA E ALTRI ANTIPSICOTICI ATIPICI E TIPICI: INCIDENZA E DECORSO DELLE DISCRASIE EMATICHE DURANTE LE PRIME DICIOTTO SETTIMANE DI TRATTAMENTO
No full textSCOPO
Gli studi di confronto tra le discrasie ematiche da clozapina e quelle da antipsicotici Tipici ed Atipici non sono
molti in letteratura. Sono stati esaminati incidenza e decorso delle discrasie indotte da clozapina durante le
prime diciotto settimane di trattamento rispetto a quelle da Tipici ed Atipici.
MATERIALI E METODI
Lo studio include 135 pazienti trattati con clozapina (M 75 e F 60), 75 con altri Atipici (M 35 e F40) e 75 con i
Tipici (M 39 e F 36), che sono stati ricoverati presso il Dipartimento di Psichiatria dell’Università di Napoli SUN
a partire dal Dicembre 1992 al Maggio 2011. I pazienti inclusi sono quelli che hanno completato le diciotto
settimane di trattamento e che hanno completato la documentazione dei dati.
RISULTATI
Si è rilevato che l’eosinofilia persistente è presente nel 36.8% dei trattati con clozapina, 4%, (p<.05) e 2.7%,
(p<.05), rispettivamente, dei trattati con Atipici e Tipici; la leucocitosi persistente nel 26.5% dei trattati con
clozapina, 13.3% e 18.7% dei trattati, rispettivamente, con Atipici e Tipici. La neutrofilia persistente, invece,
nel 27.2% dei soggetti trattati con clozapina, 12.0% con Atipici e 10.7%, (p=.027) con i Tipici. Inoltre, l’anemia
persistente nei trattati con clozapina ha presentato un’incidenza pari al 45.6% (62/136) rispetto all’8% (6/75),
(p<.05) dei trattati con Atipici e al 12% (9/75), (p<.05) dei trattati con i Tipici. Lo studio ha evidenziato nei
trattati con clozapina una maggiore rilevanza dell’anemia persistente in pazienti di sesso femminile (p<.001).
CONCLUSIONI
Prima di iniziare il trattamento con antipsicotici è importante conoscerne non solo rischi e benefici, ma anche
l’entità di questi, al fine di impostare la terapia più adeguata al paziente, ed evitare brusche modificazioni della
stessa alla comparsa di alterazioni ematologiche non rilevanti da un punto di vista clinico, e che non compromettono
la vita del pazient
Antipsychotic treatment and metabolic syndrome: a retrospective study in schizophrenic and bipolar patients
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