1,720,968 research outputs found
Breast cancer classification through multivariate radiomic time series analysis in DCE-MRI sequences
Get PDFBreast cancer is the most prevalent disease that poses a significant threat to women’s health. Despite the Dynamic Contrast-Enhanced MRI (DCE-MRI) has been widely used for breast cancer classification, its diagnostic performance is still suboptimal. In this work, the Radiomic workflow was implemented to classify the whole DCE-MRI sequence based on the distinction in contrast agent uptake between benign and malignant lesions. The radiomic features extracted from each of the seven time instants within the DCE-MRI sequence were fed into a multi-instant features selection strategy to select the discriminative features for time series classification. Several time series classification algorithms including Rocket, MultiRocket, K-Nearest Neighbor, Time Series Forest, and Supervised Time Series Forest were compared. Firstly, a univariate classification was performed to find the five most informative radiomic series, and then, a multivariate time series classification was implemented via a voting mechanism. The Multivariate Rocket model was the most accurate (Accuracy = 0.852, AUC-ROC = 0.852, Specificity = 0.823, Sensitivity = 0.882). The intelligible radiomic features enabled model findings explanations and clinical validation. In particular, the Energy and TotalEnergy were among the most important features, and the most descriptive for the change in signal intensity, which is the main effect of the contrast agent
Interpretable Radiomic Signature for Breast Microcalcification Detection and Classification
Get PDFBreast microcalcifications are observed in 80% of mammograms, and a notable proportion can lead to invasive tumors. However, diagnosing microcalcifications is a highly complicated and error-prone process due to their diverse sizes, shapes, and subtle variations. In this study, we propose a radiomic signature that effectively differentiates between healthy tissue, benign microcalcifications, and malignant microcalcifications. Radiomic features were extracted from a proprietary dataset, composed of 380 healthy tissue, 136 benign, and 242 malignant microcalcifications ROIs. Subsequently, two distinct signatures were selected to differentiate between healthy tissue and microcalcifications (detection task) and between benign and malignant microcalcifications (classification task). Machine learning models, namely Support Vector Machine, Random Forest, and XGBoost, were employed as classifiers. The shared signature selected for both tasks was then used to train a multi-class model capable of simultaneously classifying healthy, benign, and malignant ROIs. A significant overlap was discovered between the detection and classification signatures. The performance of the models was highly promising, with XGBoost exhibiting an AUC-ROC of 0.830, 0.856, and 0.876 for healthy, benign, and malignant microcalcifications classification, respectively. The intrinsic interpretability of radiomic features, and the use of the Mean Score Decrease method for model introspection, enabled models' clinical validation. In fact, the most important features, namely GLCM Contrast, FO Minimum and FO Entropy, were compared and found important in other studies on breast cancer
Shallow and deep learning classifiers in medical image analysis
Get PDFAbstract An increasingly strong connection between artificial intelligence and medicine has enabled the development of predictive models capable of supporting physicians’ decision-making. Artificial intelligence encompasses much more than machine learning, which nevertheless is its most cited and used sub-branch in the last decade. Since most clinical problems can be modeled through machine learning classifiers, it is essential to discuss their main elements. This review aims to give primary educational insights on the most accessible and widely employed classifiers in radiology field, distinguishing between “shallow” learning (i.e., traditional machine learning) algorithms, including support vector machines, random forest and XGBoost, and “deep” learning architectures including convolutional neural networks and vision transformers. In addition, the paper outlines the key steps for classifiers training and highlights the differences between the most common algorithms and architectures. Although the choice of an algorithm depends on the task and dataset dealing with, general guidelines for classifier selection are proposed in relation to task analysis, dataset size, explainability requirements, and available computing resources. Considering the enormous interest in these innovative models and architectures, the problem of machine learning algorithms interpretability is finally discussed, providing a future perspective on trustworthy artificial intelligence. Relevance statement The growing synergy between artificial intelligence and medicine fosters predictive models aiding physicians. Machine learning classifiers, from shallow learning to deep learning, are offering crucial insights for the development of clinical decision support systems in healthcare. Explainability is a key feature of models that leads systems toward integration into clinical practice. Key points • Training a shallow classifier requires extracting disease-related features from region of interests (e.g., radiomics). • Deep classifiers implement automatic feature extraction and classification. • The classifier selection is based on data and computational resources availability, task, and explanation needs. Graphical Abstrac
Explainable Machine-Learning Models for COVID-19 Prognosis Prediction using Clinical, Laboratory and Radiomic Features
Get PDFThe SARS-CoV-2 virus pandemic had devastating effects on various aspects of life: clinical cases, ranging from mild to severe, can lead to lung failure and to death. Due to the high incidence, data-driven models can support physicians in patient management. The explainability and interpretability of machine-learning models are mandatory in clinical scenarios. In this work, clinical, laboratory and radiomic features were used to train machine-learning models for COVID-19 prognosis prediction. Using Explainable AI algorithms, a multi-level explainable method was proposed taking into account the developer and the involved stakeholder (physician, and patient) perspectives. A total of 1023 radiomic features were extracted from 1589 Chest X-Ray images (CXR), combined with 38 clinical/laboratory features. After the pre-processing and selection phases, 40 CXR radiomic features and 23 clinical/laboratory features were used to train Support Vector Machine and Random Forest classifiers exploring three feature selection strategies. The combination of both radiomic, and clinical/laboratory features enabled higher performance in the resulting models. The intelligibility of the used features allowed us to validate the models' clinical findings. According to the medical literature, LDH, PaO2 and CRP were the most predictive laboratory features. Instead, ZoneEntropy and HighGrayLevelZoneEmphasis - indicative of the heterogeneity/uniformity of lung texture - were the most discriminating radiomic features. Our best predictive model, exploiting the Random Forest classifier and a signature composed of clinical, laboratory and radiomic features, achieved AUC=0.819, accuracy=0.733, specificity=0.705, and sensitivity=0.761 in the test set. The model, including a multi-level explainability, allows us to make strong clinical assumptions, confirmed by the literature insights
Rad4XCNN: A new agnostic method for post-hoc global explanation of CNN-derived features by means of Radiomics
Get PDFBackground and Objective: In recent years, machine learning-based clinical decision support systems (CDSS) have played a key role in the analysis of several medical conditions. Despite their promising capabilities, the lack of transparency in AI models poses significant challenges, particularly in medical contexts where reliability is a mandatory aspect. However, it appears that explainability is inversely proportional to accuracy. For this reason, achieving transparency without compromising predictive accuracy remains a key challenge. Methods: This paper presents a novel method, namely Rad4XCNN, to enhance the predictive power of CNN-derived features with the inherent interpretability of radiomic features. Rad4XCNN diverges from conventional methods based on saliency maps, by associating intelligible meaning to CNN-derived features by means of Radiomics, offering new perspectives on explanation methods beyond visualization maps. Results: Using a breast cancer classification task as a case study, we evaluated Rad4XCNN on ultrasound imaging datasets, including an online dataset and two in-house datasets for internal and external validation. Some key results are: (i) CNN-derived features guarantee more robust accuracy when compared against ViT-derived and radiomic features; (ii) conventional visualization map methods for explanation present several pitfalls; (iii) Rad4XCNN does not sacrifice model accuracy for their explainability; (iv) Rad4XCNN provides a global explanation enabling the physician to extract global insights and findings. Conclusions: Our method can mitigate some concerns related to the explainability-accuracy trade-off. This study highlighted the importance of proposing new methods for model explanation without affecting their accuracy
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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