1,720,986 research outputs found
Norman G. Bowery: A Founding Father of the GABAB Receptor Research Field: Reflections on His Contribution (Second Edition)
Get PDFThis chapter is dedicated to the history of Norman George Bowery and his groundbreaking discovery of GABAB receptor. This chapter focuses on Norman’s brilliant career from the beginning, toward his retirement, and to the legacy that he left in the scientific community: that is why Norman is called the “Father of GABAB receptor.” Reported here are the first evidence of GABAB receptor existence spanning to the pharmacological characterization, the following development of Norman’s own group on GABAB receptor, and the huge innovation that he brought to the scientific community because the GABAB receptor is a major factor in the central nervous system inhibition; therefore, when not working properly, it is involved in many diseases. The chapter also reports about the collaboration between Norman Bowery and Alessandra Princivalle, who was so honored and fortunate to have the opportunity to work with such an inspirational and worldwide recognized scientist and is now the author of this work. This chapter consider a brief overview of the latest Noman’s work, before moving to GlaxoSmithKline, Verona, Italy. This chapter concludes with the greatest recognition to Norman Bowery for being Norman and discovering the GABAB receptor
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Studies of biomarkers in temporal lobe epilepsy.
Get PDFRefractory temporal lobe epilepsy associated with hippocampal sclerosis (TLE-HS) affects about 30% of TLE patients, where antiepileptic drugs are not effective in controlling seizures. These patients become candidates for surgical treatment which is effective in only 60-70% of cases. In addition, surgical treatment causes memory and cognitive impairments as well as psychopathological disturbance. Therefore, the aim of this study is to investigate potential biomarkers in surgically resected sclerotic TLE-HS (n = 49) and non-spiking superior temporal gyrus samples (TLE-STG; n = 25) from TLE patients and post-mortem hippocampi (PMC; n = 10), in order to increase our understanding of refractory TLE pathophysiology and help in identifying new potential drug targets for treatment of TLE patients. GABA b receptor subunits were investigated in TLE-HS, TLE-STG and PMC tissue by quantitative real time polymerase chain reaction (qRT-PCR) and quantitative western blot (WB) techniques. Alterations in expressions of SGK1, SCN4B, IP3R1 and SYNPR were investigated in TLE-HS, TLE-STG and PMC specimens by qRT-PCR and WB. The transcriptome profiling of TLE-HS, TLE-STG and PMC samples was done by microarray analysis (MA). MA was followed by functional annotation clustering analysis (FAC) of the MA differentially expressed genes (DEGs). Genes from FAC analysis were further investigated by qRT-PCR. MA Aquaporin (AQP1, 3, 4, 5, 8, 9, 11) expressions were further validated by qRT-PCR. Expression of the inhibitory GABA b2 receptor subunit was significantly up regulated in TLE-HS compared to PMC but its expression was reduced in TLE-HS compared to TLE-STG.The expression of SCN4B, IP3R1 and SYNPR, which are involved in regulating neuronal excitability, were significantly reduced in TLE-HS compared to TLE-STG and were significantly increased compared to PMC. The expression of SGK1 mRNA was significantly increased in TLE-HS compared to both TLE-STG and PMC. MA analysis revealed 1821 genes were significantly up regulated and 1511 genes were significantly down regulated in TLE-HS compared to TLE-STG and PMC. The first cluster from FAC analysis of DEGs showed that the up regulated inflammatory genes such as cytokines had the highest enrichment score. The qRT-PCR data showed that expression of IL-1B, IL-18, Fas, ICAM-1, CCL2, CCL4, CXCL1, CXCL2, CXCL12, CXCR4 and CX3CR1 were significantly higher in TLE-HS compared to TLE-STG and PMC therefore validating MA data. AQP1 and -4, which are involved in water homeostasis, were significantly up regulated in TLE-HS compared to TLE-STG. AQP11 expression was significantly reduced in TLE-HS while AQP3, -5, -8 and -9 were not significantly altered in TLE-HS compared to TLE-STG and PMC. The significant dysregulation of biomarker expression investigated in this study indicate that different biological processes such as neuronal excitability, neuronal and astrocytic energy metabolism, neurogenesis, apoptosis, neuroinflammation, intracellular calcium and water homeostasis are affected in the epileptogenic TLE-HS tissue. These biomarkers seem to be associated with TLE-HS pathophysiology. Furthermore, they highlight the role of neuronal, astrocytic, microglia and endothelial cell dysfunction in TLE-HS pathology. In conclusion, the biomarkers investigated increased our understanding of biological processes affected in TLE-HS pathophysiology and they represent potential drug targets for refractory TLE-HS. However, further research is still needed to understand the temporal and spatial changes of those genes and their proteins during TLE
- …
