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    Ruptured “occult” aneurysm disclosed by three-dimensional angiographic reconstructions.

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    Rotational angiographic sequences and their three-dimensional reconstructions have led to major improvements in angiographic diagnostics, especially in the study of brain aneurysms. Reconstructions accurately depict the morphology of the aneurysm, namely any wall irregularities and the possible origin of arterial branches from the aneurysmal sac, and display the aneurysm on multiple spatial planes, measuring its different diameters and ratios (particularly the dome to neck ratio). Lastly, three-dimensional angiographic reconstructions will sometimes disclose ruptured or intact aneurysms not depicted by digital subtraction angiography. A 43-year-old woman was admitted to the emergency room of Maggiore Hospital, Bologna Local Health Trust, presenting severe headache, confusion and nuchal rigidity. Emergency CT scan disclosed cisternal subarachnoid haemorrhage. Subsequent 3D sequences revealed an aneurysm of the left carotid artery siphon. This occult aneurysm found in our patient had been masked by the overlying infundibular origin of the posterior communicating artery. This prevented detection of the lesion not only in standard oblique anteroposterior, craniocaudal and lateral sequences but also in the rotational sequence. Identification of the aneurysm in our patient was the result of the diagnostic strategy adopted. When cisternal subarachnoid haemorrhage is detected, our protocol routinely includes a rotational angiographic sequence centred on the anterior circulation and on the posterior circulation when the standard examination fails to depict the course of all the vessels or when the features of subarachnoid haemorrhage strongly suggest aneurysm rupture in that anatomical location. Three-dimensional angiographic reconstructions are extremely useful not only to characterize brain aneurysms, but also to disclose ruptured occult aneurysms and additional zero grade lesions

    Aneurysmal and Perianeurysmal Changes After Endovascular Treatment: from Inflammation to Microbleed. A Case Report.

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    The advent of flow diverter (FD) stents has deeply changed the endovascular treatment of cerebral aneurysms. Endosac- cular devices have been replaced by endoluminal stents and the management of FD-treated patients differs markedly from that of patients treated with metal coils. Whichever technique or devices are used, a thrombus forms within the aneurysmal sac after treatment. The ensuing events are well known: clot formation and inflammation develop in a physiological healing process that takes from months to years These new devices have also given rise to several unpre- dictable complications, including still unexplained fatal case of spontaneous rupture of treated aneurysms The mechanism of post-flow-diversion haemorrhage remains difficult to clearly understand: aneurysm thrombosis, fol lowed by mural inflammation, leading to autolysis and rupture has been described.Nevertheless thrombosis followed by organization and neo-intimal closure of the neck is required for successful occlusion of treated aneurysms, thus there must be further elements to consider for thrombosis leading to rupture rather than occlusion. This report describes the favourable outcome of a focal wall rupture affecting a large carotid-ophthalmic artery aneurysm treated with FD and coils deployment. It displays the potential interaction between thrombosis, inflammation and residual flow in the aneurysm

    Treatment of carotid siphon aneurysms with a microcell stent. A case report.

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    The treatment of giant, large, multiple or wide-necked carotid siphon aneurysms has always represented a challenge for neurosurgeons and neuroradiologists. Very recently the use of stents with tiny holes has been proposed by two companies: Balt Silk Stent in Europe and Pipeline in America. We have used the Silk stent on a few patients and describe our first case who now has an eleven. month follow-up. The carotid siphon presented three converging aneurysms sharing a very large common neck. The Silk stent (Balt Extrusion, Montmorency, France) was deployed through a 4F Balt introducer. The procedure was uneventful and very quick. As soon as the stent was positioned contrast medium stagnation was displayed within. the aneurysm. The patient's post-operative course was normal and she was discharged three days later in good health

    Straged treatment of a blood blister-like aneurysm with stent-assisted coiling follone by flow diverter in-stent insertion. A case report.

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    Blood blister-like aneurysms (BBLA) are rare lesions sometimes difficult to recognize and in most cases associated with diffuse subarachnoid haemorrhage and severe clinical conditions. BBLA are life-threatening because they tend to enlarge rapidly and to rebleed, and no consensus has so far been reached on the best management strategy. We describe a patient with a BBLA in the right ICA treated successful by a two-stage embolization procedure first with coils and an open cell stent (Neuroform 3) and later by further coil placement and insertion of a flow-diverting stent (Silk)

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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