5,730 research outputs found
Sir Victor Horsley: pioneer craniopharyngioma surgeon
No full textSir Victor Horsley (1857–1916) is considered to be the pioneer of pituitary surgery. He is known to have performed the first surgical operation on the pituitary gland in 1889, and in 1906 he stated that he had operated on 10 patients with pituitary tumors. He did not publish the details of these procedures nor did he provide evidence of the pathology of the pituitary lesions operated on. Four of the patients underwent surgery at the National Hospital for Neurology and Neurosurgery (Queen Square, London), and the records of those cases were recently retrieved and analyzed by members of the hospital staff. The remaining cases corresponded to private operations whose records were presumably kept in Horsley’s personal notebooks, most of which have been lost.
In this paper, the authors have investigated the only scientific monograph providing a complete account of the pituitary surgeries that Horsley performed in his private practice, La Patologia Chirurgica dell’Ipofisi (Surgical Pathology of the Hypophysis), written in 1911 by Giovanni Verga, Italian assistant professor of anatomy at the University of Pavia. They have traced the life and work of this little-known physician who contributed to the preservation of Horsley’s legacy in pituitary surgery. Within Verga’s pituitary treatise, a full transcription of Horsley’s notes is provided for 10 pituitary cases, including the patients’ clinical symptoms, surgical techniques employed, intraoperative findings, and the outcome of surgery. The descriptions of the topographical and macroscopic features of two of the lesions correspond unmistakably to the features of craniopharyngiomas, one of the squamous-papillary type and one of the adamantinomatous type. The former lesion was found on necropsy after the patient’s sudden death following a temporal osteoplastic craniectomy. Surgical removal of the lesion in the latter case, with the assumed nature of an adamantinomatous craniopharyngioma, was successful. According to the evidence provided in Giovanni Verga’s monograph, it can be claimed that Sir Victor Horsley was not only the pioneer of pituitary gland surgery but also the pioneer of craniopharyngioma surger
A new acylated quercetin glycoside from Ranunculus lanuginosus
No full textA new acylated quercetin glycoside, quercetin 3-O-(2-t-p-coumaroyl)-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside , together with the known 3-(3,4-dihydroxyphenyl)lactic acid were isolated from Ranunculus lanuginosus leaves and identified on the basis of detailed spectral anal., including 2D-NMR spectrometry and ESI-M
Optimización del plan de gestión de mantenimiento preventivo en la empresa Montajes JM s.a.s Bogotá, Colombia
No full textEl proyecto esta basado en la optimización de un plan de gestión de mantenimiento preventivo en la empresa Montajes JM S.A.S. Para ello, se realizó una investigación documental, debido a la necesidad de obtener especificaciones técnicas de los equipos. La información se obtuvo mediante registros de mantenimiento y gestión. La población y muestra corresponde a la empresa Montajes JM S.A.S. Se logró, optimizar el plan de mantenimiento para la empresa de servicios de ingeniería Montajes JM S.A.S. Seguidamente, se ejecutó el diagnóstico del sistema actual de gestión del mantenimiento. Posteriormente, se desarrolló un sistema de información técnica y documental de los vehículos y maquinarias. Finalmente, se elaboró un plan de mantenimiento anual que operará con información técnica y documental.PregradoIngeniero(a) Mecánico(a
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
Anti-inflammatory activity of beta-sitosterol in a model of oxazolone-induced contact delayed type hypersensitivity.
No full textTo <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
Furostanol saponins and quercetin glycosides from the leaves of Helleborus viridis L
No full textPhytochem. anal. of the polar exts. of the leaves of Helleborus viridis (Ranunculaceae) resulted in the isolation of two new furostanol saponins (25R)-26-[(alfa-L-rhamnopyranosyl)oxy]-22alfa-methoxyfurost-5-en-3beta-yl O-beta-D-glucopyranosyl-(1-3)-O-[6-acetyl-beta-D-glucopyranosyl-(1-3)]-O-beta-D-glucopyranoside (1) and (25R)-26-[(alfa-L-rhamnopyranosyl)oxy]-22alfa-methoxyfurost-5-en-3beta-yl O-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(13)-O-beta-D-glucopyranoside (2) and three new quercetin glycosides, quercetin 3-O-(2-E-caffeoyl)-alfa-L-arabinopyranosyl-(1-2)-beta-D-galactopyranoside-7-O-beta-D-glucopyranoside (3), quercetin 3-O-(2-E-caffeoyl)-alfa-L-arabinopyranosyl-(1-2)-beta-D-galactopyranoside (4), and quercetin 3-O-alfa-L-arabinopyranosyl-(1-2)-beta-D-galactopyranoside (5). The structures of the new compds. were detd. by spectroscopic anal., including 2D NMR data and mass spectrometry
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
Interaction of gadolinium with phospholipids bilayer membranes - Photon correlation spectroscopy and DSC study
No full textA non-invasive spectroscopic study to evaluate both technological features and conservation state of two types of ancient Roman coloured bricks
No full textThe study of both original and decaying compounds is relevant in understanding the chemistry behind the deterioration processes, above all in open museum contexts where environmental stressors affect the artefacts. In this sense, a combination of non-invasive spectroscopy techniques (Raman spectroscopy, μ-X-ray fluorescence and X-ray diffraction) was applied on an ancient Roman building (130 CE), the “Casa di Diana” Mithraeum at Ostia Antica archaeological site. The aim is to study the raw materials, manufacturing and decaying products of the two observed types of Roman fired bricks (red and yellow) that compose the building.
The present study estimates an illite raw material of carbonate-bearing marine clay likely referring to the common deposits of central/southern Italy, which contain calcite as accessory phase and a-plastic fraction constituted by quartz, feldspar and opaques. This clay material was added with volcanic temper characterised by abundant clinopyroxene and analcime (from analcimization of leucite) that are typical of the Roman Province volcanism. The firing would be probably the result of oxidizing conditions, as proved by the hematite presence. Thanks to the existence of specific neoformed mineral phases during firing it was possible to assess different temperatures ranges. In detail, the red/orange bricks, for the existence of gehlenite (formed from calcite and its reaction with silicates), were fired at 800–900 °C range; whereas, the yellow ones are characterised by the lack of gehlenite and the disappearance of illite/muscovite, which indicates firing temperature at over 900 °C.
Regarding the decaying products, the gypsum covers most of the surface of most bricks, both red and the yellow ones, but these latter are more susceptible to environmental stressors (sulphates and carbonates).
Therefore, this work points out how by integrated non-invasive approaches it is possible trace back to original firing temperature, technology of manufacture, interpreting ceramic data
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