159 research outputs found
Folic acid supplementation during pregnancy and its association with telomere length in children at four years: results from the inma birth cohort study
No full textPetermann-Rocha F., Valera-Gran D., Prieto-Botella D., Martens D.S., Gonzalez-Palacios S., Riaño-Galán I., Murcia M., Irizar A., Julvez J., Santa-Marina L., Tardón A., Sunyer J., Vioque J., Nawrot T., Navarrete-Muñoz E.-M
FOLIC ACID SUPPLEMENTATION DURING PREGNANCY AND ITS ASSOCIATION WITH TELOMERE LENGTH IN CHILDREN AT FOUR YEARS OF AGE: RESULTS FROM THE INMA PROJECT
No full textFOLIC ACID SUPPLEMENTATION DURING PREGNANCY AND ITS ASSOCIATION WITH TELOMERE LENGTH IN CHILDREN AT FOUR YEARS OF AGE: RESULTS FROM THE INMA PROJECT
No full textRed squirrels from south-east Iberia: low genetic diversity at the southernmost species distribution limit
No full textArdillas rojas del sureste ibérico: baja diversidad genética en el límite austral de la distribución de la especie
El sureste ibérico es el límite más austral de la distribución de esta especie en Europa, donde las ardillas habitan principalmente en bosques de Pinus. En este estudio, se investigó el patrón de variación genética mitocondrial de las ardillas rojas del sureste ibérico. Se secuenciaron fragmentos de dos genes mitocondriales, 350 pares de bases de la región control (D–loop) y 359 pb del citocromo b (Cytb) utilizando muestras obtenidas a partir de 88 ardillas atropelladas. Se encontró una baja variación genética, lo cual podría explicarse por la existencia de un cuello de botella reciente causado por la sobreexplotación histórica de los recursos madereros de la zona. La pérdida y fragmentación del hábitat debidas a la deforestación y al aislamiento geográfico podrían explicar la fuerte subdivisión genética observada entre las regiones del estudio. Se describen seis nuevos haplotipos para el fragmento D–loop y dos para el Cytb. Un haplotipo encontrado en el sureste ibérico para el Cytb se observó también en Albania y Japón, lo que sugiere una extinción local de este haplotipo en áreas intermedias. En los análisis filogenéticos, no se detectó un agrupamiento significativo de las ardillas del sureste ibérico, ni de ninguna otra población europea (excepto en Calabria)
Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study
No full textThis study examined the association between folic acid supplements (FAs) during different periods of pregnancy and offspring telomere length (TL) at age four in 666 children from the INMA study. FAs were self-reported using food-structured questionnaires during three periods of pregnancy (the first three months of pregnancy, from month fourth onward, and the whole pregnancy). For each period, the average daily dosage of FAs was categorised into (i) <400 μg/d, (ii) ≥400 to 999 μg/d, (iii) ≥1000 to 4999 μg/d, and (iv) ≥5000 μg/d. Leucocyte TL at age four was measured using quantitative PCR methods. Multiple robust linear log-level regression models were used to report the % difference among FA categories. During the first period, and compared with children whose mothers were classified in the reference group (<400 μg/d), children whose mothers took higher dosages of FAs showed shorter TL at age four (≥5000 μg/d). When the first and the second periods were mutually adjusted, children whose mothers self-reported ≥5000 μg/d during the first period of pregnancy had a statistically significant shorter TL than their counterparts (% difference: −7.28% [95% CI: −14.42 to −0.13]). Similar trends were observed for the whole period of pregnancy. When the analysis was stratified by sex, the association was more evident in boys (% difference: −13.5% [95% CI: −23.0 to −4.04]), whereas no association was observed in girls. This study suggests that high dosages of FAs in the first pregnancy period may be associated with a shorter TL in children at age four, particularly among boys. Further studies should confirm these results.This research was funded by Instituto de Salud Carlos III/Agencia Estatal de Investigación, grant number PI18/00825 Project: “Dieta y actividad física en embarazo y tras el nacimiento y longitud del telómero en niños y adolescentes: Proyecto TeloDiPA” and Unión Europea (FEDER) “Una manera de hacer Europa”; PI07/0314, PI11/01007 incl. FEDER funds; Generalitat Valenciana (GVA/2021/191); Dries Martens holds a postdoctoral grant by the Flemish Scientific Fund (FWO grant 12X9620N). In Sabadell was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds, PI15/00118 incl. FEDER funds, CPII18/00018), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010), EU Commission (261357, 308333, 603794 and 634453). We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. In Asturias was funded by ISCIII: PI04/2018, PI09/02311, PI13/02429, PI18/00909 co-funded by FEDER, “A way to make Europe”/“Investing in your future”, Obra Social Cajastur/Fundación Liberbank, and Universidad de Oviedo. This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867 and FIS-PI09/00090), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069 and 2013111089), and the Provincial Government of Gipuzkoa (DFG06/002 and DFG08/001) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). Jordi Julvez holds the Miguel Servet-II contract (CPII19/00015) awarded by the Instituto de Salud Carlos III (co-funded by the European Social Fund “Investing in your future”)
Capítulo 10: Los “ninis”: jóvenes que no trabajan ni estudian en una colonia de Guadalajara Jalisco, México
No full textLa botella de salsa Valentina se vacía hasta casi la tercera parte: es la
de etiqueta negra, la más picosa y temida por quienes padecen úlcera
gástrica. Rancio anega con ella su paquete grande de frituras de harina de papa, disolviéndolas, volviendo el contenido de la bolsa de botanas en una mezcla acuosa color ámbar. Antes, agregó el jugo de tres
limones completos, sal de grano y generosas cucharadas de una salsa
mexicana, típica del barrio, la cual contiene una mezcla explosiva de
jitomate, cebolla, cilantro y repollo, finamente picados, amén de sendas
rebanadas de chiles habaneros frescos, casi un veneno de tan enchilosos. Rancio anuda con destreza su bolsa de churritos de medio kilo,
sellándola por fuera y luego perfora con sus grandes dientes amarillentos y deteriorados su lado opuesto, realizando un pequeño orificio
por donde succionará la potente mezcla para ingerirla.http://unidadinvestigacion.usta.edu.c
Concentración de vitamina D en niños diabéticos de tipo 1. Asociación con el control glucémico y el metabolismo óseo y lipídico
No full textIntroducción: debido a que la vitamina D juega un papel primordial en la regulación de la secreción de insulina y su déficit parece conferir un mayor riesgo de desarrollar diabetes mellitus, se ha pretendido analizar la prevalencia del déficit de vitamina D en nuestra población de niños diabéticos de tipo 1 y si se relaciona con un peor control de la enfermedad, así como con el metabolismo lipídico y óseo.
Material y métodos: se trata de un estudio retrospectivo en el cual se disponía de los datos clínicos y analíticos de 124 niños diabéticos de tipo 1, controlados en la Unidad de Diabetes Pediátrica de nuestro hospital.
Resultados: la concentración mediana de vitamina D del total de la muestra fue de 25,41 (7,43) ng/mL, siendo más elevada en el sexo masculino que en el femenino (p = 0,006). Un 43,55 % de los niños presentaron buen control metabólico, con hemoglobina glicosilada inferior al 7,5 %, siendo la concentración de glucosa y la de colesterol ligeramente más bajas, y la de fosfatasa alcalina ósea más elevada, cuando la concentración de vitamina D era ≥ 20 ng/ml.
Conclusiones: no hemos encontrado diferencias significativas en el control metabólico de los niños con concentración suficiente o insuficiente de vitamina D. Los niños del estudio tenían concentraciones de vitamina D muy parecidas a las de un estudio similar en niños sanos, así como un buen control metabólico de su diabetes, siendo su perfil óseo y lipídico más favorable cuando presentaban buen control metabólico
Classically studied coherent structures only paint a partial picture of wall-bounded turbulence
No full text[EN] For the last 140 years, the mechanisms of transport and dissipation of energy in a turbulent flow have not been completely understood. Previous research has focused on analyzing the so-called coherent structures, organized flow patterns characterized by their spatial coherence, lifespan and significant contribution to momentum and energy transfer. However, the connection between these structures and the flow development is still uncertain. Here, we show a data-driven methodology for objectively identifying high-importance regions. A deep-learning model is trained to predict a future state of the flow and the gradient-SHAP explainability algorithm is used to calculate the importance of each grid point. Finally, high-importance regions are computed using the SHAP data and are compared to the other coherent structures. The SHAP analysis provides an objective way to identify the regions of higher importance, which exhibit different levels of agreement with the classical structures without being completely related to any particular one.The authors acknowledge Adrián Lozano-Durán and Álvaro MartíinezSánchez for their support with the validation of the causal nature of the
SHAP values. The deep-learning-model training was enabled by
resources provided by the National Academic Infrastructure for Supercomputing in Sweden (NAISS) at Berzelius (NSC), partially funded by the
Swedish Research Council through grant agreement no. 2022-06725.
Part of the postprocessing was made in the supercomputer Sirius of the
Universitat Politècnica de València. SH has the support of grant PID2021-
128676OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by
ERDF A way of making Europe , by the European Union. RV acknowledges the financial support from ERC grant no. 2021-CoG-101043998,
DEEPCONTROL. Views and opinions expressed are however those of the
author(s) only and do not necessarily reflect those of the European Union
or the European Research Council. Neither the European Union nor the
granting authority can be held responsible for them.
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Parallel implementation of the multiple endmember spectral mixture analysis algorithm for hyperspectral unmixing
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