1,584 research outputs found
Recommended from our members
A study of John Clare in his historical and political context
No full textAs the title indicates, the basis of the thesis is to set John Clare’s life and work within the context of the social and political history of his time. It is a study that is long overdue. The manner in which topical and political matters were mediated to him and were reflected in his work are analysed. His introduction to the literary and social worlds of Stamford and London is evaluated, and the advantages and disadvantages of patronage assessed. The active and complex political culture of Stamford has been taken into account as this may have affected his later political statements and a growing awareness of his audience. His antagonism to enclosure and the social changes that it engendered are considered. Three major questions that arise from this are addressed. The two local newspapers that Clare is known to have read are used throughout. His correspondence with friends, colleagues and casual correspondents has provided valuable insights as have his poetry and prose writings. Research in the Northamptonshire Record Office has revealed important new information in the form of one book of Enclosure Commissioners’ Minutes dated 1809-14, the first five years of the enclosure of Helpstone, Clare’s native village
Progress and Distress on the Stratford Estate in Clare during the Eighteen Forties
Get PDFIn the late 1980s and early 1990s, the author acquired about 30,000 letters written mainly in the 1840s. These pertained to estates throughout Ireland managed by James Robert Stewart and Joseph Kincaid, hereafter denoted SK. Until the letters - called the SK correspondence in what follows - became the author’s property, they had not seen light of day since the 1840s. Addressed mainly to the SK office in Dublin, they were written mainly by landlords, tenants, the partners in SK, local agents, etc. After about 200 years in operation as a land agency, the firm in which members of the Stewart family were the principal partners - Messrs J. R. Stewart & Son(s) from the mid-1880s onwards -- ceased business in the mid-1980s. Since 1994 the author has been researching the SK correspondence of the 1840s. It gives many new insights into economic and social conditions in Ireland during the decade of the great famine, and into the operation of Ireland’s most important land agency during those years. It is intended ultimately to publish details on several of the estates managed by SK in book form. The proposed title is Landlords, Tenants, Famine: Business of an Irish Land Agency in the 1840s, a draft of which has now been completed. A majority of the letters in the larger study from which the present article is drawn are on themes some of which one might expect - rents, distraint (seizure of assets in lieu of rent) ; ‘voluntary’ surrender of land in return for ‘compensation’ upon peacefully quitting; formal ejectment (a matter of last resort on estates managed by SK); landlord-assisted emigration (on a scale much more extensive than most historians of Ireland in the 1840s appear to believe); petitions from tenants; complaints by tenants, both about other tenants and local agents; major works of improvement (on almost all of the estates managed by SK); applications by SK, on behalf of proprietors, for government loans to finance improvements; recommendations of agricultural advisers hired by SK, ete. Thus, most of the SK correspondence is about aspects of estate management. It seems, in the 1840s, that the only estate in Clare managed by SK was that of the elderly Col. Stratford. Although the files on the relatively small Stratford estate are much less extensive than those on some of the estates investigated in detail in the draft of Landlords, Tenants, Famine, they do refer to most of the core aspects of estate management mentioned above. But in the case of the Clare estate, the material on some of those themes is extremely thin.
Author interview: considering Emma Goldman with Professor Clare Hemmings
Get PDFWe speak to Professor Clare Hemmings about her new book, Considering Emma Goldman: Feminist Political Ambivalence and the Imaginative Archive (Duke UP, 2018), which examines Goldman’s significance as an anarchist activist and thinker to the past and present of feminist theories and activism. Hemmings shows that the contradictions and tensions within Goldman’s approach to race, gender and sexuality speak to unresolved questions that continue to shape feminist practices and politics today
Why feminist stories matter: Katy Deepwell interviews Clare Hemmings
No full textClare Hemmings is Professor of Feminist Theory and Director of the Gender Institute at the London School of Economics. She is the author of Why Stories Matter: The Political Grammar of Feminist Theory (Duke University Press, 2011). For this volume, Katy Deepwell interviewed her about her views on feminist historiography and feminist theory, which Hemmings has defined in terms of three dominant narratives about the direction of feminism’s past, present and future
The life and works of Osbert of Clare
No full textOsbert of Clare was an English monastic writer, whose works extended from
the mid-1120s to the mid-1150s. His Latin hagiography reflects a deep admiration for
Anglo-Saxon saints and spirituality, while his letters provide a personal perspective
on his turbulent career. As prior of Westminster Abbey, Osbert of Clare worked to
strengthen the rights and prestige of his monastery. His production of forged or
altered charters makes him one of England's most prolific medieval forgers. At times
his passion for reform put him at odds with his abbots, and he was sent into exile
under both Abbot Herbert (1121-c.1136) and Abbot Gervase (1138-c.1157). Also
Osbert, as one of the first proponents of the Immaculate Conception of Mary, wrote
about the feast, worked to legitimize its celebration, and provided us with the only
significant narration of its introduction to England.
This thesis is divided into two sections. The first section is principally
historical and the second is principally literary. In the first section, I provide an
overview of Osbert of Clare's career and examine in greater detail two of his most
significant undertaking: his promotion of Westminster Abbey and his attempted
canonization of Edward the Confessor. In the second section, I give a philological
study of Osbert Latin style and examine themes that nm throughout his writings, such
as virginity, exile and kingship. Osbert's promotion of the feast of the Immaculate
Conception is included in the second section of the thesis because of its ties to the
themes of virginity and femininity within his writings. There are also two appendices:
the first is a survey of the extant manuscripts of Osbert's writings, and the second is
an edition of Osbert's unpublished Life of St Ethelbert from Gotha,
Forschungsbibliothek MS Memb. i. 8l
Observations on the nature and cure of abscesses, [electronic resource] : and of wounds in general; with a particular account of the art of healing, and the great utility of medical surgery. Chiefly Selected from Authors who have written on this important Subject. By Peter Clare, Surgeon.
No full textThe second 24pp. section contains 'Observations upon the origin and art of surgery in general';the last few paged and unpaged leaves contain letters to Peter Clare on surgical matters.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Microglia regulate myelin growth and integrity in the central nervous system white matter
Get PDFDisruption of myelin structure occurs with ageing and neurodegenerative
disease, and involves myelin which is outfolding, unravelling, less compact,
and thicker. This is associated with nerve dysfunction and cognitive decline;
however, the mechanisms underpinning appropriate myelin structure, i.e.
myelin integrity, are unclear.
The central nervous system (CNS)-resident macrophages microglia are prime
candidates, as they are considered to instruct maturation of the myelinproducing
oligodendrocytes and thus, myelin formation in development and
following demyelination, based on studies of microglial depletion following
loss-of-function of the pro-survival colony stimulating factor 1 receptor
(CSF1R).
As this approach also targets other CNS macrophages which may contribute
to these processes, I sought to investigate the specific roles of microglia in
regulating myelin health. To achieve this, I utilised a recently developed
transgenic mouse model, in which deletion of the FIRE super-enhancer of the
Csf1r gene (FIREΔ/Δ) leads to an absence of microglia, while other CNS
macrophages are present.
FIREΔ/Δ mice had no impairment in oligodendrocyte maturation or myelin
formation in the white matter, yet showed a loss of its integrity, with impaired
compaction, increased thickness and outfoldings and unravelling of myelin,
culminating in demyelination. Results were recapitulated by depleting
microglia in adulthood, indicating a role for microglia in myelin maintenance
rather than development. These myelin changes were associated with
impaired cognitive flexibility. Loss of myelin integrity was also observed in a
human condition (ALSP) where CSF1R mutations result in reduced white
matter microglia and dementia.
To identify the mechanism by which microglia regulate myelin integrity, singlecell
RNA sequencing of FIREΔ/Δ mice was performed, which revealed a new
oligodendrocyte subpopulation. The genes upregulated in this oligodendrocyte
population were predicted to be regulated by transforming growth factor β 1
(TGFβ1), a factor primarily produced by microglia, which regulates expression
ii
of its receptors e.g., TGFβR1. Accordingly, TGFβ1 levels in FIREΔ/Δ white
matter were reduced, and oligodendroglial TGFβR1 expression was
downregulated. Additionally, the conditional knockout of Tgfbr1 in mature
oligodendrocytes was sufficient to cause a loss of myelin integrity, mirroring
the results in the FIREΔ/Δ mice. Reinstating TGFβ downstream signalling via
administration of a small molecule agonist (SRI-011381) rescued the loss of
myelin integrity in FIREΔ/Δ mice, significantly reducing inner tongue
enlargement and myelin thickness versus vehicle-treated mice such that these
were comparable to wildtype controls.
My findings reveal that microglia regulate myelin health at later stages than
previously thought, preserving the structural integrity of myelin rather than
driving initial myelin formation. These findings have important implications for
understanding the pathological mechanisms underpinning loss of myelin
integrity in ageing and neurodegenerative diseases, where dysregulated
microglia may represent key therapeutic targets to restore CNS health
Voor 't gewone leven ongeschikt. Een biografie van Clare Lennart
Get PDF
Voor ’t gewone leven ongeschikt. A biography of Clare Lennart, is a literary and historical biography of author Clare Lennart (Clara Helena van den Boogaard-Klaver, 1889-1972). Her work contains many recognisably autobiographical elements, especially from her youth. An extensive overview of the life of this 'forgotten author' is the basis for this critical and interpretive biography. In addition it shows Clare Lennart's unique position in her time, the unusual choices she made and ‘the roads not taken’ in her life. The main focus of the research is the question of how Clare Lennart gained an economic position as a woman of letter. A second question focuses on the concepts of posture and self-fashioning. The thesis demonstrates that Clare Lennart was aware of her image as a 'poetic nature lover' and that she openly presented herself as a hack writer. Clare Lennart's poetic style nowadays seems more dated than the sober language used by contemporary authors. Nevertheless, she had a large audience between 1945 and 1972 and the reception was nearly always positive. The biography discusses the contemporary reception of her work in detail and why Clare Lennart's work is omitted from the Dutch canon, using the concept of ‘middle-brow’ literature.Modern and Contemporary Studie
120 - Anna Clare Monlezun
No full textDepartment of Ecosystem Science and Sustainability.Natural Resources Ecology Lab.Warner College of Natural Resources.Includes bibliographical references.2020 Fall.Could conceptualizing cattle as partners in conservation be a win-win for the livestock and rangeland conservation sectors, resolving the [often] paradoxical objectives of food production and natural resource management? To learn more about the collaborative grazing management that occurs across much of Colorado's rangelands, we are conducting an investigation of partnerships between private ranchers and government-owned land managers along the Front Range. Our research process addresses the sustainability of these rangelands as complex social-ecological systems where livestock production and natural resource conservation are woven together in a tapestry of management, culture, and science. Recent literature indicates that scientific research engaging the ecological, economic and social elements of grazing management is lacking. Therefore, our study reflects a holistic model evaluating these three components of sustainability (ecological, economic, and social) to answer our overarching question: Can strategic grazing partnerships on multi-use government-owned landscapes achieve the dual goals of assisting land management agencies with natural resource conservation, and ranchers with maintaining sustainable beef production? We are exploring multiple themes in alignment with the three components of sustainability: soil health, plant biodiversity, forage nutritive quality, ecosystem services, and socio-cultural values. System dynamics modeling will be used to examine relationships and interactions among these themes within and across our study sites. System dynamics modeling will allow us to apply qualitative and quantitative context-specific variables to generate and visualize management alternatives that will ultimately aid in adaptive and integrated decision-making. Our intention is to produce results that are meaningful to stakeholders, solution-focused, and application-oriented
- …
