709 research outputs found
Candidate Gene Analysis of the Price Foundation Anorexia Nervosa Affected Relative Pair Dataset
No full textThe eating disorders are severe psychiatric illnesses with significant morbidity and mortality that exhibit statistically significant familial risk and heritability, providing support for a molecular genetic approach toward defining etiological factors. An emerging candidate gene literature has concentrated on serotinergic and dopaminergic candidates. With the financial support of the Price Foundation, a group of investigators initiated an international multi-center collaboration (Price Foundation Collaborative Group) in 1995 to study the genetics of anorexia and bulimia nervosa by collecting and analyzing phenotypes and genotypes of individuals and their relatives affected with eating disorders. The first sample of families collected by this collaborative group, known as the Price Foundation Anorexia Nervosa Affected Relative Pair (AN-ARP) dataset, was ascertained on an proband affected with Anorexia Nervosa (AN), with relative pairs affected with the eating disorders AN, Bulimia Nervosa or Eating Disorders Not Otherwise Specified [1]. Biognosis U.S., Inc. was founded to identify and characterize candidate susceptibility genes for anorexia and bulimia nervosa phenotypes in the Price Foundation eating disorder datasets. During 2000-2001, Biognosis U.S., Inc. developed and implemented a research program with a focus on the analysis of candidate genes nominated by neurochemical characteristics of eating disorder patients [2], serotonergic and dopaminergic candidate gene polymorphisms [3], neuroendocrine regulation of appetite [4], and by a positional hypothesis from a linkage analysis of the AN-ARP dataset [5]. This report reviews the anorexia nervosa candidate gene literature through 2001, the candidate gene research program implemented at Biognosis U.S., Inc. and selected candidate gene findings in the AN-ARP dataset derived from that research program
Collaborative approach: a foundation for successful decommissioning
No full text
The industrial capability to decommission assets is in its formative stages, with knowledge and experience limited to a few organisations. Many see this intellectual property as a competitive advantage, underpinning an entrepreneurial approach to secure a share of the projected future spends. While success is usually measured by performance and profit, Wood Group has adopted a broader perspective. Choosing, along with others, to collaborate and actively share lessons, knowledge, and experience for the benefit of the industry and government. Any future strategy for decommissioning developed from the foundation of shared tools and guidance documents will maximise economic recovery for society.
The author outlines the journey so far, identifying the key drivers for collaboration to date, and set out a vision for the next stages. They advocate a truly collaborative approach that shares knowledge between the basins the industry operates in, thus allowing operators to maximise recovery and discharge their license obligations through a cost-effective approach to decommissioning.
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Development and leadership in computer-mediated collaborative groups
No full textComputer-mediated collaboration is an important feature of modern organisational and educational settings. Despite its ever increasing popularity, it is still commonly compared unfavourably with face-to-face collaboration because non-verbal and paralinguistic cues are minimal. Although research on face-to-face group collaboration is well documented, less is known about computer-mediated collaboration.
The initial focus of this thesis was an in-depth analysis of a case study of a computer-mediated collaborative group. The case study was a large international group of volunteer researchers who collaborated on a two-year research project using asynchronous communication (email). This case study was a window on collaborative dialogue in the early 1990s (1992-94) at a time when information and communication technologies were at an early stage of development.
After identifying the issues emerging from this early case study, another case study using technologies and virtual environments developed over the past decade, was designed to further understand how groups work together on a collaborative activity. The second case study was a small group of students enrolled in a unit of study at Murdoch University who collaborated on a series of nine online workshops using synchronous communication (chat room). This case study was a window on collaborative dialogue in the year 2000 when information and communication technologies had developed at a rate which few people envisioned in the early 90s.
The primary aim of the research described in this thesis was to gain a better understanding of how computer-mediated collaborative communities develop and grow. In particular, the thesis addresses questions related to the developmental and leadership characteristics of collaborative groups.
Internet research requires a set of assumptions relating to ontology, epistemology, human nature and methodological approach that differs from traditional research assumptions. A research framework for Internet research - Complementary Explorative Data Analysis (CEDA) - was therefore developed and applied to the two case studies.
The results of the two case studies using the CEDA methodology indicate that computer-mediated collaborative groups are highly adaptive to the aim of the collaborative task to be completed, and the medium in which they collaborate. In the organisational setting, it has been found that virtual teams can devise and complete a collaborative task entirely online. It may be an advantage, but it is certainly not mandatory to have preliminary face-to-face discussions. What is more important is to ensure that time is allowed for an initial period of structuration which involves social interaction to develop a social presence and eventually cohesiveness. In the educational setting, a collaborative community increases pedagogical effectiveness. Providing collaborative projects and interdependent tasks promotes constructivist learning and a strong foundation for understanding how to collaborate in the global workplace. Again, this research has demonstrated that students can collaborate entirely online, although more pedagogical scaffolding may be required than in the organisational setting. The importance of initial social interaction to foster a sense of presence and community in a mediated environment has also been highlighted.
This research also provided greater understanding of emergent leadership in computer-mediated collaborative groups. It was found that sheer volume of words does not make a leader but frequent messages with topic-related content does contribute to leadership qualities.
The results described in this thesis have practical implications for managers of virtual teams and educators in e-learning
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial and updated meta-analysis
No full textAcknowledgments Above all, we thank the thousands of patients who participated in this trial. We also thank the many doctors, nurses, pharmacists, other allied health professionals, and research administrators at National Health Service hospital organisations across the whole of the UK, supported by staff at the National Institute of Health Research (NIHR) Clinical Research Network, NHS DigiTrials, Public Health England, Department of Health & Social Care, the Intensive Care National Audit & Research Centre, Public Health Scotland, National Records Service of Scotland, the Secure Anonymised Information Linkage at the University of Swansea, and the NHS in England, Scotland, Wales, and Northern Ireland. The RECOVERY trial is supported by grants to the University of Oxford from UK Research and Innovation and NIHR (MC_PC_19056), the Wellcome Trust (grant reference 222406/Z/20/Z) through the COVID-19 Therapeutics Accelerator, and by core funding provided by the NIHR Oxford Biomedical Research Centre, the Wellcome Trust, the Bill and Melinda Gates Foundation, the Foreign, Commonwealth and Development Office, Health Data Research UK, the Medical Research Council Population Health Research Unit, the NIHR Health Protection Unit in Emerging and Zoonotic Infections, and NIHR Clinical Trials Unit Support Funding. TJ is supported by a grant from UK Medical Research Council (MC_UU_00002/14). WSL is supported by core funding provided by NIHR Nottingham Biomedical Research Centre. Tocilizumab was provided free of charge for this trial by Roche Products. Regeneron Pharmaceuticals supported the trial through provision of casirivimab and imdevimab. Baricitinib was provided from routine NHS stock. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.Peer reviewe
Scope, Scale, and Sustainability: What It Takes to Create Lasting Community Change
No full text· This article examines success factors that relate specifically to the ability of a comprehensive community initiative (CCI) to achieve the scope and scale required to generate community-level outcomes and to sustain those positive impacts over time.
· The CCIs selected for study represent a wide range of goals, strategies, and organizational structures.
· Six factors were found to cut across scope, scale, and sustainability. These factors include having a single broker or entity that holds the vision of the change effort; clearly defined roles; alignment among interventions, resources, and geography; meaningful community engagement; competent leadership and staff; and strategic, cross-level relationships.
· Additional factors were found to relate to success in achieving scope, scale, or sustainability individually.
· Lessons include to plan, operate, and evaluate based on a systems- and community-change framework; choose focused and affordable strategies; build the capacity to use data; and plan for change and conflict
The Medical Treatment of Depression, 1991-1996: Productive Inefficiency, Expected Outcome Variations, and Price Indexes
No full textWe examine the price of treating episodes of acute phase major depression over the 1991-1996 time period. We combine data from a large retrospective medical claims data base (MarketScanTM, from the MedStat Group) with clinical literature and expert clinical opinion elicited from a two-state Delphi procedure. This enables us to construct a variety of treatment price indexes that include variations over time in the proportion of off-frontier' production, as well as the corresponding variations in expected treatment outcomes. We also incorporate the fact that the no treatment option ( waiting list') frequently results in spontaneous remission of depressive symptoms. We find that in general the incremental cost of successfully treating an episode of acute phase major depression has generally fallen over the 1991-96 time period. Based on hedonic regression equations that account for the effects of changing patient mix, we find price reductions that range from about -1.66% to -2.13% per year. An implication of this is that, since expenditures on depression are thought to be increasing since at least 1991, the source of the spending increases is volume (quantity) increases, and not price increases.
Dialogue and Collaboration in the Creation of New Works for Clarinet
No full textThis PhD thesis explores dialogue-based, “intimate” collaboration through the creation of new works for clarinet. It borrows from Grounded Theory in order to facilitate an analysis through which emergent themes within a dialogue-based
collaboration are discovered. The aim has not been to insist on one model of collaboration, but to discover methods for improving one’s collaborative skills and to identify ways in which one benefits from a focus on dialogue in
collaboration. Furthermore, it aims to suggest that through collaboration one can make discoveries about the instrument: original contributions to clarinet technique are made within this thesis. The literature from which the research draws inspiration to further collaborative “technique” is cross-disciplinary and wide-ranging: it draws from social theory, collaborative creative writing, dance, the visual arts and of course, music. Added to this is a select discussion of collaboration throughout the repertoire of the clarinet. Finally, this consists of practice-based research. Seven new pieces for clarinet accompany the text
Temporal characterization of the requests to Wikipedia
No full textThis paper presents an empirical study about the temporal patterns
characterizing the requests submitted by users to Wikipedia.
The study is based on the analysis of the log lines registered by the
Wikimedia Foundation Squid servers after having sent the appropriate
content in response to users' requests. The
analysis has been conducted regarding the ten most visited editions of
Wikipedia and has involved more than 14,000 million log lines
corresponding to the traffic of the entire year 2009. The conducted methodology
has mainly consisted in the parsing and filtering
of users' requests according to the study directives. As a result, relevant information
fields have been finally stored in a database for persistence and further
characterization. In this way, we, first, assessed, whether the traffic to Wikipedia could serve
as a reliable estimator of the overall traffic to all the Wikimedia Foundation
projects. Our subsequent analysis of the temporal evolutions corresponding to
the different types of requests to Wikipedia revealed interesting differences
and similarities among them that can be related to the users' attention to the Encyclopedia.
In addition, we have performed separated characterizations of each Wikipedia edition
to compare their respective evolutions over time
Wrestling with Japanese Tribalism Emerging Collaborative Opportunities For India and Japan
No full textJapanese firms, with their strong technology base and high domestic factor costs, have the potential of teaming with India, with its more basic infrastructure and eight times the population. Japan's poorly-performing excess capital could fuel India's strongly-developing middle class and robust entrepreneurialism. Especially promising are collaborative information technology projects. What stands in the way of a greatly expanded relationship? Much of the blockage stems from Japan's insularism, an impetus here labeled tribalism. A hopeful dimension is that this tribalism can be clearly defined as archaic, recognized as detrimental, and then toned-down. Further points for development include an active campaign to encourage diversity in Japan, teaming up to provide alternatives to investment in neighboring China, and agitating for representation on the UN Security Council. India can help initiate all these processes, and can in turn benefit from a Japan reaching out for regional economic partnerships.homogeneity; tribalism; UN Security Council; partnership; immigration; trade; e-Japan strategy
Students' perceptions of issues arising from and factors influencing group interaction in computer conferencing : a grounded theory approach.
No full textThe present study aimed to identify students' perceptions of issues arising from and factors influencing on-line group interaction and dynamics in computer conferencing in higher education by recording the perceptions of a group of students who acted as members of on- line groups. The emergent objectives were to develop recommendations and guidelines for the effective deployment of on-line group interaction and elements of a possible model. The research has taken an inductive interpretative approach applying qualitative methods. Interviews were the main tool of data collection and the grounded theory approach, as developed by Strauss and Corbin in 1990, adopted for the analysis of the interview data. The analysis was also assisted by the use of the Atlas. ti software, specially designed for analysis of qualitative data. Issues of validity of qualitative research, following Lincoln and Guba's (1985) proposed criteria of establishing "trustworthiness" such as credibility, transferability, dependability and confirmability were addressed and discussed in connection to the current study. Findings of the study were placed around five main categories addressing ways group participants utilised in order to express themselves in the computer conferencing environment, issues of participation, decision-making procedures, conflicts and disagreements, and finally co-ordination issues. A number of factors affected the categories arose were identified. Relationships between the categories proposed and the code named lack of communication cues were also identified. Conclusions drawn from the study formulated guidelines and recommendations on computer conferencing issues and factors found to affect interaction among the group participants in the text-based on-line environment and proposed elements of a theory following the grounded theory procedures. Suggestions and points for further research along with implications for practice were also included
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