1,720,966 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Goldnanopartikel: Eine Plattform für multimodale Diagnostik und Therapie in der experimentellen Nuklearmedizin
No full textEs wurden Goldnanopartikel (AuNP) hergestellt, die eine einheitliche Größenverteilung von 3–5 nm aufweisen. Damit kann eine Mehrfachfunktionalisierung erreicht werden, d.h. gleich mehrere tumorspezifischen Moleküle an einen AuNP gekoppelt werden können und somit eine stark erhöhte Avidität zur Tumorzelle erzielt werden kann. Diese so hergestellten AuNP wurden mit diagnostisch oder therapeutisch wirksamen Radionukliden beladen bzw. radiomarkiert. Diese so funktionalisierten und radiomarkierten AuNP reicherten sich in Tumorgewebe an mit nur geringfügiger Akkumulation in gesundem Gewebe.:1. Einleitung 1
1.1 Radioaktive Arzneimittel zur Diagnostik und Therapie in der Nuklearmedizin 1
1.2 Radioaktives Gold gegen Krebs 2
1.3 Aktueller Stand der Forschung zu Goldnanopartikeln 3
1.4 Chemische Charakterisierung von oberflächen-modifizierten AuNP 5
1.5 Zielstellung 7
2. Ergebnisse 8
2.1 Gastrin-Releasing Peptide Receptor- and Prostate-Specific Membrane Antigen-Specific Ultrasmall Gold Nanoparticles for Characterization and Diagnosis of Prostate Carcinoma via Fluorescence Imaging 8
2.2 Targeted 64Cu-labeled gold nanoparticles for dual imaging with positron emission tomography and optical imaging 20
2.3 αvβ3-Specific gold nanoparticles for fluorescence imaging of tumor angiogenesis 34
2.4 68Ga-NeoB: Preclinical results on imaging of gastrointestinal stromal tumors and determination of target receptor density in the gastrointestinal tract 65
2.5 GMP-compliant production of [68Ga]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor 80
2.6 Ac-EAZY! Towards GMP-Compliant Module Syntheses of 225Ac-Labeled Peptides for Clinical Application 93
3. Diskussion 105
3.1 Entwicklung von klinisch anwendbaren radiomarkierten Goldnanopartikeln gegen Krebs 105
3.2 Klinische Translation von neuen diagnostischen und therapeutischen Radiopharmaka 106
4. Zusammenfassung und Ausblick 108
5. Literaturverzeichnis 110
Abkürzungsverzeichnis 115
Erklärungen und Versicherung 117Gold nanoparticles (AuNPs) with a uniform size distribution of 3-5 nm were produced. This allows multiple functionalization to be achieved, i.e. several tumour-specific molecules can be coupled to one AuNP at the same time and thus a greatly increased avidity to the tumour cell can be achieved. These AuNPs produced in this way were loaded or radiolabeled with diagnostically or therapeutically effective radionuclides. These functionalized and radiolabeled AuNPs accumulated in tumour tissue with only slight accumulation in healthy tissue.:1. Einleitung 1
1.1 Radioaktive Arzneimittel zur Diagnostik und Therapie in der Nuklearmedizin 1
1.2 Radioaktives Gold gegen Krebs 2
1.3 Aktueller Stand der Forschung zu Goldnanopartikeln 3
1.4 Chemische Charakterisierung von oberflächen-modifizierten AuNP 5
1.5 Zielstellung 7
2. Ergebnisse 8
2.1 Gastrin-Releasing Peptide Receptor- and Prostate-Specific Membrane Antigen-Specific Ultrasmall Gold Nanoparticles for Characterization and Diagnosis of Prostate Carcinoma via Fluorescence Imaging 8
2.2 Targeted 64Cu-labeled gold nanoparticles for dual imaging with positron emission tomography and optical imaging 20
2.3 αvβ3-Specific gold nanoparticles for fluorescence imaging of tumor angiogenesis 34
2.4 68Ga-NeoB: Preclinical results on imaging of gastrointestinal stromal tumors and determination of target receptor density in the gastrointestinal tract 65
2.5 GMP-compliant production of [68Ga]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor 80
2.6 Ac-EAZY! Towards GMP-Compliant Module Syntheses of 225Ac-Labeled Peptides for Clinical Application 93
3. Diskussion 105
3.1 Entwicklung von klinisch anwendbaren radiomarkierten Goldnanopartikeln gegen Krebs 105
3.2 Klinische Translation von neuen diagnostischen und therapeutischen Radiopharmaka 106
4. Zusammenfassung und Ausblick 108
5. Literaturverzeichnis 110
Abkürzungsverzeichnis 115
Erklärungen und Versicherung 11
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Entwicklung von Radiotracern für die radiopharmakologische Charakterisierung von Eph-Rezeptoren
Full text linkEph receptors are known to be overexpressed in various types of cancer and are therefore promising targets for tumor cell imaging by positron emission tomography (PET). In this regard, imaging could facilitate the early detection of Eph-overexpressing tumors, monitoring responses to therapy directed toward Eph, and thus improvement in patient outcomes.
This work report the synthesis and evaluation of several fluorine-18-labeled peptides containing the SNEW and SWLAY amino acid motif, with high affinity for the EphA2 and B2 receptor, for their potential as radiotracers in the non-invasive imaging of cancer using PET. For the purposes of radiofluorination, EphA2- and EphB2-antagonistic peptides were varied at the C-terminus by the introduction of L-cysteine, and further by alkyne- or azide-modified amino acids. In addition, two novel bifunctional and bioorthogonal labeling building blocks [18F]AFP and [18F]BFP were applied, and their capacity to introduce fluorine-18 was compared with that of the established building block [18F]FBAM.
Copper-assisted Huisgen 1,3-dipolar cycloaddition, which belongs to the set of bioorthogonal click chemistry reactions, was used to introduce both novel building blocks into azide- or alkyne-modified peptides under mild conditions. Finally, the depletion of copper immediately after radiolabeling is a highly important step of this novel methodology
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Goldnanopartikel: Eine Plattform für multimodale Diagnostik und Therapie in der experimentellen Nuklearmedizin
No full textEs wurden Goldnanopartikel (AuNP) hergestellt, die eine einheitliche Größenverteilung von 3–5 nm aufweisen. Damit kann eine Mehrfachfunktionalisierung erreicht werden, d.h. gleich mehrere tumorspezifischen Moleküle an einen AuNP gekoppelt werden können und somit eine stark erhöhte Avidität zur Tumorzelle erzielt werden kann. Diese so hergestellten AuNP wurden mit diagnostisch oder therapeutisch wirksamen Radionukliden beladen bzw. radiomarkiert. Diese so funktionalisierten und radiomarkierten AuNP reicherten sich in Tumorgewebe an mit nur geringfügiger Akkumulation in gesundem Gewebe.:1. Einleitung 1
1.1 Radioaktive Arzneimittel zur Diagnostik und Therapie in der Nuklearmedizin 1
1.2 Radioaktives Gold gegen Krebs 2
1.3 Aktueller Stand der Forschung zu Goldnanopartikeln 3
1.4 Chemische Charakterisierung von oberflächen-modifizierten AuNP 5
1.5 Zielstellung 7
2. Ergebnisse 8
2.1 Gastrin-Releasing Peptide Receptor- and Prostate-Specific Membrane Antigen-Specific Ultrasmall Gold Nanoparticles for Characterization and Diagnosis of Prostate Carcinoma via Fluorescence Imaging 8
2.2 Targeted 64Cu-labeled gold nanoparticles for dual imaging with positron emission tomography and optical imaging 20
2.3 αvβ3-Specific gold nanoparticles for fluorescence imaging of tumor angiogenesis 34
2.4 68Ga-NeoB: Preclinical results on imaging of gastrointestinal stromal tumors and determination of target receptor density in the gastrointestinal tract 65
2.5 GMP-compliant production of [68Ga]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor 80
2.6 Ac-EAZY! Towards GMP-Compliant Module Syntheses of 225Ac-Labeled Peptides for Clinical Application 93
3. Diskussion 105
3.1 Entwicklung von klinisch anwendbaren radiomarkierten Goldnanopartikeln gegen Krebs 105
3.2 Klinische Translation von neuen diagnostischen und therapeutischen Radiopharmaka 106
4. Zusammenfassung und Ausblick 108
5. Literaturverzeichnis 110
Abkürzungsverzeichnis 115
Erklärungen und Versicherung 117Gold nanoparticles (AuNPs) with a uniform size distribution of 3-5 nm were produced. This allows multiple functionalization to be achieved, i.e. several tumour-specific molecules can be coupled to one AuNP at the same time and thus a greatly increased avidity to the tumour cell can be achieved. These AuNPs produced in this way were loaded or radiolabeled with diagnostically or therapeutically effective radionuclides. These functionalized and radiolabeled AuNPs accumulated in tumour tissue with only slight accumulation in healthy tissue.:1. Einleitung 1
1.1 Radioaktive Arzneimittel zur Diagnostik und Therapie in der Nuklearmedizin 1
1.2 Radioaktives Gold gegen Krebs 2
1.3 Aktueller Stand der Forschung zu Goldnanopartikeln 3
1.4 Chemische Charakterisierung von oberflächen-modifizierten AuNP 5
1.5 Zielstellung 7
2. Ergebnisse 8
2.1 Gastrin-Releasing Peptide Receptor- and Prostate-Specific Membrane Antigen-Specific Ultrasmall Gold Nanoparticles for Characterization and Diagnosis of Prostate Carcinoma via Fluorescence Imaging 8
2.2 Targeted 64Cu-labeled gold nanoparticles for dual imaging with positron emission tomography and optical imaging 20
2.3 αvβ3-Specific gold nanoparticles for fluorescence imaging of tumor angiogenesis 34
2.4 68Ga-NeoB: Preclinical results on imaging of gastrointestinal stromal tumors and determination of target receptor density in the gastrointestinal tract 65
2.5 GMP-compliant production of [68Ga]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor 80
2.6 Ac-EAZY! Towards GMP-Compliant Module Syntheses of 225Ac-Labeled Peptides for Clinical Application 93
3. Diskussion 105
3.1 Entwicklung von klinisch anwendbaren radiomarkierten Goldnanopartikeln gegen Krebs 105
3.2 Klinische Translation von neuen diagnostischen und therapeutischen Radiopharmaka 106
4. Zusammenfassung und Ausblick 108
5. Literaturverzeichnis 110
Abkürzungsverzeichnis 115
Erklärungen und Versicherung 11
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