889 research outputs found
Mind “De GaPP”: in vitro efficacy of deferiprone and gallium-protoporphyrin against Staphylococcus aureus biofilms
No full textData source: Supporting information, http://onlinelibrary.wiley.com/doi/10.1002/alr.21735/abstract#footer-support-infoAbstract not availableKatharina Richter, Mahnaz Ramezanpour, Nicky Thomas, Clive A. Prestidge, Peter-John Wormald and Sarah Vreugd
Clive Small on the real-life "Underbelly"
No full textOver the course of his career, Clive Small, one of NSW\u27s most successful detectives, saw it all. His book, "Smack Express: How organised crime got hooked on drugs" is an insight into drug trafficking and organised crime on Australia\u27s east coast. Written with journalist Tom Gilling, it features an extraordinary range of colourful characters and situations. Take "Aunty", the female drug lord who has been successfully importing kilos of cocaine into Australia for decades. Or the bloke who thought that throwing someone into the boot of a car and driving it to South Australia wasn\u27t kidnapping, because "he never asked to get out of the boot".
Clive Small is a former Assistant Commissioner of Police in NSW, and a former ICAC chief investigator. He resigned from ICAC in 2007 to pursue a defamation case against broadcaster Alan Jones. His investigations included the death of Griffith anti-drugs campaigner Donald McKay, the assassination of Cabramatta MP John Newman and the backpacker murders of Ivan Milat.
Tom Gilling is a former journalist and author. He has written a number of novels and co-authored "The Bagman: Final Confessions of Jack Herbert", about a corrupt Queensland policeman whose evidence in the 1980s Fitzgerald Inquiry had a huge impact on Queensland
Photograph - Burrows, Geoff, Accounting and Business Law, and Clive Morton, co-author, after receiving award for their book ‘The Canecutters’
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/283960Burrows, Geoff, Accounting and Business Law, and Clive Morton, co-author, after receiving award for their book ‘The Canecutters’286830
Item: [2003.0003.00938] "Photograph - Burrows, Geoff, Accounting and Business Law, and Clive Morton, co-author, after receiving award for their book ‘The Canecutters’
Photograph - Burrows, Geoff, Accounting and Business Law, and Clive Morton, co-author, who won award for their book ‘The Canecutters’
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/283981Burrows, Geoff, Accounting and Business Law, and Clive Morton, co-author, who won award for their book ‘The Canecutters’ 27 Feb 1987286851
Item: [2003.0003.00959] "Photograph - Burrows, Geoff, Accounting and Business Law, and Clive Morton, co-author, who won award for their book ‘The Canecutters’
Review of “St. Clive:” An Eastern Orthodox Author Looks Back at C. S. Lewis
No full textReview of C. J. S. Hayward, “St. Clive:” An Eastern Orthodox Author Looks Back at C. S. Lewis (Wheaton, Illinois: C. J. S. Hayward Publications, 2000-19). 381 pages. $49.99. ISBN 9781794669956
Silica-lipid hybrid (SLH) microcapsules: a novel oral delivery system for poorly soluble drugs
No full textAbstract not availableAngel Tan, Spomenka Simovic, Andrew K. Davey, Thomas Rades, Clive A. Prestidg
Temperature-induced gelation of emulsions stabilised by responsive copolymers: A rheological study
No full textThe steady-state and dynamic rheological properties of 1-bromohexadecane-in-water emulsions stabilised by responsive poly(N-isopropylacrylamide)-co-poly(ethyleneglycol methacrylate) (poly(NIPAM-co-PEGMa)) copolymer have been investigated. The data were compared to measurements performed using dilute and concentrated poly(NIPAM-co-PEGMa) copolymer solutions. These solutions exhibit viscosities that decrease and increase, respectively, with increasing temperature. The increase in viscosity for the concentrated solution is attributed to transient network formation. The presence of dispersed oil droplets (volume fraction = 0.30) in the emulsion causes temperature-induced gelation even though the copolymer concentration in the aqueous phase is such that transient network formation due to overlapping copolymer chains throughout the aqueous phase does not occur. Dynamic rheological data confirmed gelation for the emulsions at elevated temperatures. Emulsion gelation is attributed to flocculation between neighbouring droplets. The adhesive droplets form a network that entraps the aqueous phase. The strength of the network increased with increasing temperature. To our knowledge these data represent the first comprehensive rheological investigation of reversible, temperature-induced gelation for an oil-in-water emulsion.Andrew Y. C. Koh, Clive Prestidge, Igor Ametov and Brian R. Saunder
Plasma functionalized PDMS microfluidic chips: towards point-of-care capture of circulating tumor cells
No full textThe main challenge in the isolation of circulating tumor cells (CTCs) resides in their extreme rarity in blood. Here we report on the design of efficient and disposable microfluidic CTC capture devices based on the plasma functionalization of PDMS and its subsequent conjugation with the anti-epithelial-cell adhesion-molecule (EpCAM) mAb. Model studies on planar surfaces demonstrated excellent immuno-specificity of cancer-cell capture using NCI H69 small-cell lung cancer cells and SK-Br-3 breast cancer cells. Taking advantage of the transparency of the PDMS device, direct observation of the capture events on the internal 3D microstructure of the device could be achieved. At a flow rate of 16 μL min−1, an overall capture efficiency of 80 to 90% is determined in cell-spiking experiments in PBS. In accordance with direct microscopic observations, an increased flow rate (48 μL min−1) only has a minor effect (30% reduction) on cell-capture efficiency. Capture efficiency of the device using cancer cells spiked in whole blood is above 70%. The combination of soft lithography and plasma-based functionalization described in this work enables the facile fabrication of efficient and disposable CTC capture devices based on PDMS, which could facilitate the transition of this new technology into the clinical environment.Mahaveer D. Kurkuri, Fares Al-Ejeh, Jun Yan Shi, Dennis Palms, Clive Prestidge, Hans J. Griesser, Michael P. Brown and Benjamin Thierr
A topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity
No full textAccepted manuscript posted online 10 April 2017Many infectious diseases are associated with multidrug-resistant (MDR) bacteria residing in biofilms that require high antibiotic concentrations. While oral drug delivery is frequently ineffective, topical treatments have the potential to deliver higher drug concentrations to the infection site while reducing systemic side effects. This study determined the antibiofilm activity of a surgical wound gel loaded with the iron chelator deferiprone (Def) and the heme analogue gallium-protoporphyrin (GaPP), alone and in combination with ciprofloxacin. Activity against MDR Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Acinetobacter johnsonii biofilms was assessed in the colony biofilm and artificial wound model by enumeration of CFU and correlative light/electron microscopy. While Staphylococcus biofilms were equally susceptible to GaPP and Def-GaPP gels (log10 reduction of 3.8 and 3.7, respectively), the Def-GaPP combination was crucial for significant activity against P. aeruginosa biofilms (log10 reduction of 1.3 for GaPP and 3.3 for Def-GaPP). When Def-GaPP gel was combined with ciprofloxacin, the efficacy exceeded the activity of the individual compounds. Def-GaPP delivered in a surgical wound gel showed significant antibiofilm activity against different MDR strains and could enhance the gel's wound-healing properties. Moreover, Def-GaPP indicated a potentiation of ciprofloxacin. This antibiofilm strategy has potential for clinical utilization as a therapy for topical biofilm-related infections.Katharina Richter, Nicky Thomas, Jolien Claeys, Jonathan McGuane, Clive A. Prestidge, Tom Coenye, Peter-John Wormald, Sarah Vreugd
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