39 research outputs found
A bioinformatics resource for TWEAK-Fn14 signaling pathway
No full textTNF-related weak inducer of apoptosis (TWEAK) is a new member of the TNF superfamily. It signals through TNFRSF12A, commonly known as Fn14. The TWEAK-Fn14 interaction regulates cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, tissue remodeling and inflammation. Although TWEAK has been reported to be associated with autoimmune diseases, cancers, stroke, and kidney-related disorders, the downstream molecular events of TWEAK-Fn14 signaling are yet not available in any signaling pathway repository. In this paper, we manually compiled from the literature, in particular those reported in human systems, the downstream reactions stimulated by TWEAK-Fn14 interactions. Our manual amassment of the TWEAK-Fn14 pathway has resulted in cataloging of 46 proteins involved in various biochemical reactions and TWEAK-Fn14 induced expression of 28 genes. We have enabled the availability of data in various standard exchange formats from NetPath, a repository for signaling pathways. We believe that this composite molecular interaction pathway will enable identification of new signaling components in TWEAK signaling pathway. This in turn may lead to the identification of potential therapeutic targets in TWEAK-associated disorders.Mitali Bhattacharjee, Rajesh Raju, Aneesha Radhakrishnan, Vishalakshi Nanjappa, Babylakshmi Muthusamy, Kamlendra Singh, Dheebika Kuppusamy, Bhavya Teja Lingala, Archana Pan, Premendu Prakash Mathur, H. C. Harsha, T. S. Keshava Prasad, Gerald J. Atkins, Akhilesh Pandey, and Aditi Chatterje
Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: An in vivo and in silico study
No full text
Modeling, docking, simulation, and inhibitory activity of the benzimidazole analogue against β-tubulin protein from Brugia malayi for treating lymphatic filariasis
No full textThe various applications and methodological aspects of Finite element analysis in Dental Traumatology Research- A systematic review
No full text1. Review title.
The various applications and methodological aspects of Finite element analysis in Dental Traumatology Research- A systematic review
2. Original language title.
English
3. Anticipated or actual start date.
31-1-2022
4. Anticipated completion date.
30-3-2022
5. Stage of review at time of this submission.
Not yet started
6. Named contact.
Dr Mohammad Atif
7. Named contact email.
[email protected]
8. Named contact address.
Dr Mohammad Atif
Senior Resident,
Division of Peodontics and Preventive Dentistry
6th Floor, Centre for Dental Education and Research
All India Institute of Medical Sciences
New Delhi, India-110029
9. Named contact phone number.
+91-7620699744
10. Organisational affiliation of the review.
Centre for Dental Education and Research
All India Institute of Medical Sciences, New Delhi-110029
11. Review team members and their organisational affiliations.
Dr Atif Mohammad, Dr Nitesh Tewari, Dr Vijay P Mathur, Dr Rahul Morankar, Dr Manjari Rishikesh, Division of Pedodontics and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India, Dr Anoop Chawla, Indian Institute of Technology, Delhi, New Delhi.
12. Funding sources/sponsors.
None
13. Conflicts of interest.
None
14. Collaborators.
None
15. Review question.
What are the various applications and methodological aspects of Finite element analysis in Dental traumatology research?
16. Searches.
The PubMed, LILACS, Web of Science, EMBASE, Scopus and Cochrane databases will be searched on 2nd February 2022 without any restriction of language and year of publication. A search of the grey literature will be performed in Google Scholar and Open-Grey. The search strategy will include the use of text words and MeSH terms to address the Population (P), Intervention (I), Comparator (C), Outcome (O) of the research question-
P- Studies related to any aspect of dental traumatology
I- Finite element analysis
C- Not required/ Not mandatory
O- Distribution of the studies in different domains of dental traumatology and their methodological aspects
The search strategy will be
Field 1:
Traumatic-Dental-Injuries OR Dental-Trauma OR Tooth-avulsion OR Tooth-Fracture OR Tooth-Trauma OR Tooth-Injuries OR Tooth-Luxation or Dental-injuries OR Crown-Fracture OR Crown-Root-fracture OR Root-Fracture OR Dento-alveolar-fracture OR Subluxation OR Concussion OR Contusion OR Lateral-Luxation OR Intrusion OR Intrusive-Luxation OR Extrusion OR Extrusive-Luxation OR Fractured-Tooth
Filed 2:
Finite-element-analysis OR Finite-element-method OR FEA OR FEM OR Finite-element-model OR Finite-element-algorithms
Partial searches with the Boolean tools AND and OR will be done with the above keywords. The translations of the Keywords will be utilized to maximize the scope of the searches. Suitable modification shall be done for different databases and search of grey literature. References of the included articles will be searched. The searches will be saved electronically in EndNote online (Clarivate Analytics), which will also be used for removing the duplicates. The Literature search will be performed independently by two reviewers (MA and NT). In event of any disagreement, the consensus will be established by consulting the senior reviewer (VM). Reference lists of eligible studies will be cross-checked to identify additional studies.
17. URL to search strategy.
None
18. Condition or domain being studied.
Application of Finite element methods in Dental traumatology research
19. Participants/population.
Studies related to any aspect of dental traumatology
Exclusion:
• Studies not related to dental trauma research.
• Letter to editors
• Short communications
20. Intervention(s), exposure(s).
Finite Element Analysis/Methods
21. Comparator(s)/control.
Not required/ Not mandatory
22. Types of study to be included.
In vitro studies, in silico
23. Context.
All studies involving the use of Finite element method in Dental traumatology will be included.
24. Main outcome(s).
Various applications of FEA in different domains dental traumatology
25. Additional outcome(s).
Methodological aspects of the FEA studies
26. Data extraction (selection and coding).
Two authors NT, MA will assess studies to determine inclusion and undertake data extraction independently. The data extraction will be done using a specially designed pre piloted data extraction form. In event of difference of opinions, the Senior Expert VM will be consulted for agreement.
27. Risk of bias (quality) assessment.
Risk of Bias for the studies will be evaluated by using self developed risk of bias tool for use of Finite element analysis in dentistry and will be done by two reviewers MA and MR independently. In event of disagreement, opinion of VP will be taken as final.
28. Strategy for data synthesis.
The data will be entered in MS Excel format and synthesized as per the desired outcome variables.
The data extraction will be done using a specially designed pre piloted data extraction form. The pilot testing of the sheet will be done in a sample of 10 studies. This will also be done for calibration of the reviewers. The different elements extracted will be-
1. Author (first author)
2. Year
3. Journal
4. Domain of TDI
5. Subdomain of TDI
6. Aim of the study described in the Population (P), Intervention (I), Comparator (C), Outcome (O)
7. Tooth/ Structure modelled
8. DICOM image/ Radiograph/ Photograph used for model development and its source.
9. Designing and Analytical Softwares used
10. 2D/3D model used
11. Static/ dynamic analysis done shape of elements
12. Number of elements and nodes in each model
13. Sub-structures defined in the model,
14. Boundary conditions
15. Restrains
16. Mechanical properties such as isotropic/anisotropic
17. Material behaviour: Linear/non-Linear/plastic/elastoplastic/viscoelastic/ viscoplastic
18. Poissons ratio
19. Youngs modulus(GPA)
20. Density of materials(g/cm3)
21. Material stiffness number
22. Damping effect (if used)
23. Range of force used
24. Point of application of force
25. Duration of force µs
26. Direction of force (Angle)
27. Shape of impact object(if modelled)
28. Degree of freedom
29. Mechanical Modelling(if done)
30. Other findings
31. disadvantage of model
29. Analysis of subgroups or subsets.
None planned
30. Type and method of review.
Systematic Review
31. Language.
English
32. Country.
India
33. Other registration details.
None
34. Reference and/or URL for published protocol.
None
35. Dissemination plans.
The systematic review will be submitted to the leading Journal in the field for publication.
36. Keywords.
Traumatic Dental Injuries, Dental Trauma, Finite element analysis, Finite element model, Finite element method, Tooth fracture.
37. Details of any existing review of the same topic by the same authors.
None
38. Current review status.
Not yet started
39. Any additional information.
This review is being undertaken to help in providing research directions for use of FEA in Dental traumatology.It will also help to evaluate the shortcomings in extrapolating the results of FEA into clinical practise. This will further aid in developing appropriate interventions for improving the same
An investigative and evaluative study of factors affecting quality of agricultural and farm information services in Kerala
No full textAgriculture is not only a country’s backbone of food, livelihood and ecological security systems, but is also the very soul of its sovereignty. In Kerala population density is high and land is scarce. To achieve sustainable advancement in quality of human life, meeting the domestic food requirement is to be given foremost priority in development plans. As the area of cultivation cannot be increased and growth of population cannot be controlled growth in food production is to be achieved by qualitative improvement in farming. This requires improvements in material inputs, farming techniques, storage technology and research. Effective integration of these factors is tied closely to adequate information flow, which can be ensured only by an efficient information system for agricultural education, research, extension and development. So evaluation and improvement of existing information services is very crucial for sustainable agricultural growth. The study evaluates the existing information resources, facilities, services, possibilities for resource sharing, accessibility of external sources, and the factors that affect the quality and efficiency of information services in agricultural sector. Coverage is limited to the State of Kerala. Sample consist 105 institutions of different levels, and information users consisting of 426 scientists and 220 farmers. Different sets of questionnaires and interview schedule were used to elicit information. The study found that agricultural research conducted at various institutions in the region at huge public expense has generated knowledge for improving production. Along with these huge collections of acquired content is also stored in the sector. But when a farmer, an extension worker, a scientist or an administrator needs information it is not easily accessible. The study found that agricultural sector fails to effectively bank on information resources available due to the lack of an information system and network. Recommends an Agricultural and Farm Information System for Kerala. Suggests a model plan for a computer communication network for resource sharing between the agricultural institutions in the State, which will also ensure, smooth flow of results of research down to the grassroots level to achieve maximum productivity in agriculture
