2,413 research outputs found
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
No full textThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
Experimental Study of Concrete Mixes with Nano-Silica and Silica Fume
No full textPh.D Thesis_Anil Kumar NandaDuring the manufacturing of cement, when limestone and clay are crushed and heated at high temperature, there is emission of global warming gasses including carbon dioxide (CO2) into the atmosphere. As the current atmospheric concentration of CO2 has reached an alarming high value to the tune of 410 ppm (April, 2017), it has become obligatory to develop ‘Green concretes’ in order to decrease the CO2 emission from cement industry. The aim of the study undertaken herein is to highlight the utilization of nano silica in high performance concrete in order to reduce the environmental pollution and to also see if the strength as well as the durability properties of the concrete can be altered positively.
In the experimental work undertaken, cement was partially replaced by nano silica at 2%, 3% & 4% replacement levels and replacement level of silica fume was kept constant at 8% for four different water binder ratios (w/b) of 0.30, 0.34, 0.38 and 0.42. The concrete samples were casted and tested for strength (compressive and split tensile) and durability properties (abrasion resistance and rapid chloride ion penetration resistance) after 7, 28 and 56 days of curing ages. Scanning Electron Microscopy, X-Ray diffraction and Energy Dispersive Spectroscopy tests were also conducted to analyze changes in the concrete microstructure. The results were statistically analyzed as well.
The test results after 56 days curing period show 34.54 % and 36.52 % increase in compressive and split tensile strength for w/b ratios 0.38 and 0.30, respectively whereas a 56.31% reduction in average loss of thickness and 38% increase in resistance of chloride ions penetration was observed for w/b ratio of 0.30. Although, the experimental results also show that the maximum increase in compressive and split tensile strength, maximum reduction in abrasion and maximum decrease in rapid chloride ion penetration value were found at 0.30 w/b ratios at the replacement level of 4% of nano silica and 8% silica fume for 56 days of curing. It is also observed that average loss of thickness decreases with the increase in compressive strength of concrete. The percentage decrease in average loss of thickness was doubled or near to double with the percentage increase in compressive strength of concrete after 28 days of curing. The Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS) test results showing the level of Ca (OH)2 in plain concrete and consumption level of Ca (OH)2 along with level of CSH in concrete containing nano silica & silica fume have also been presented. The relation between compressive strength and other properties i.e. split tensile strength, abrasion resistance and rapid chloride penetration of high-performance concrete has been developed and the results are found significant. The verification of actual compressive and rebound hammer compressive strength has been done by determining the percentage of difference between these two and found the result well within specified limit. The correlation among split tensile and compressive strength ratios has been developed to calculate the Integral Absolute Error (IAE) and it has been found that the maximum values are within specified limit. The comparison of relationship of compressive and split tensile strength of the current study with the study of other three authors has been done and found the result well within line of the study of Oluokun et al. (1991).
The reliability analysis has been done by considering the results of compressive strength of concrete in terms of mean, standard deviation and with-in-test coefficient of variation corresponding to the variation in the designated parameters which have already been generated. The compressive strength data generated experimentally has been analyzed using normal-probability distribution and partial safety factors of composite concretes have been evaluated. The experimental results show that the properties of concrete having nano silica and silica fume in combination were better than that of a plain concrete. The with-in-test coefficient of variation (WCV) being less than the acceptance value of 3.0 percent (ACI-214-77) indicates that the testing condition is uniform and under very good control. It is known that the compressive strength that is to be advised at site can be done so with greater degree of confidence if the partial safety is on lower side. There is little variation in the PSF values, for mixes with and without nano-silica and silica fume, for reliability indices of 1, 1.3 and 2.0, whereas the change is significant for β = 3.0, indicating that to achieve higher reliability at site, a strict control on water-binder ratio plays a significant role in strength development of concrete. For concrete mixes having 2% nano-silica, for a reliability index of β = 3.0, the lowest values of partial safety factors are achieved for w/b ratios of 0.38 at all ages, indicating that higher quality control is required while replicating mixes, specifically at the w/b ratio of 0.38. For all other reliability indices at all the w/b ratios the variation in the partial safety factor values is almost negligible.
It can be concluded that for mixes where early age strength is the criteria, the optimum replacement percentage of cement by nano-silica is 2 to 3%, whereas, for concrete mixes cured for normal or higher ages, it is easy to replicate mixes, containing 3 to 4% nano-silica, at the site. The partial safety factor decreases with the decrease in with-in-test coefficient of variation leading to the conclusion that a better-quality control of the concrete mixes would lead to optimal design of reinforcement for mixes containing optimal dosages of nano-silica and silica fume. The replacement of cement with nano-silica and silica fume leads to lower values of WCV and partial safety factor (PSF) indicating that it is advisable to use these supplementary cementitious materials for producing efficient RCC designs.
The results confirmed that the joint use of nano silica and silica fume has better impact on strength and durability properties than conventional concrete. The results show that the use of nano silica and silica fume as replacement of cement not only makes the concrete more durable but also reduces the emission of CO2 during the production of cement. It also solves the waste disposal problem along with saving of the natural resources
Targeting Nuclear Receptors in Lung Cancer—Novel Therapeutic Prospects
No full textLung cancer, the second most commonly diagnosed cancer, is the major cause of fatalities worldwide for both men and women, with an estimated 2.2 million new incidences and 1.8 million deaths, according to GLOBOCAN 2020. Although various risk factors for lung cancer pathogenesis have been reported, controlling smoking alone has a significant value as a preventive measure. In spite of decades of extensive research, mechanistic cues and targets need to be profoundly explored to develop potential diagnostics, treatments, and reliable therapies for this disease. Nuclear receptors (NRs) function as transcription factors that control diverse biological processes such as cell growth, differentiation, development, and metabolism. The aberrant expression of NRs has been involved in a variety of disorders, including cancer. Deregulation of distinct NRs in lung cancer has been associated with numerous events, including mutations, epigenetic modifications, and different signaling cascades. Substantial efforts have been made to develop several small molecules as agonists or antagonists directed to target specific NRs for inhibiting tumor cell growth, migration, and invasion and inducing apoptosis in lung cancer, which makes NRs promising candidates for reliable lung cancer therapeutics. The current work focuses on the importance of various NRs in the development and progression of lung cancer and highlights the different small molecules (e.g., agonist or antagonist) that influence NR expression, with the goal of establishing them as viable therapeutics to combat lung cancer
Scientometric Portrait of Homi Jehangir Bhabha: The Father of Indian Nuclear Research Programme
No full textQuantitative and qualitative analysis with graphic representation of the publication productivity of a scientist facilitates easy and clear perception about the work of a scientist. Bhabha’s scientific work spanned over more than three decades (1933-1967) during which he published 104 publications, which could be classified into nine fields: Interaction of Radiation with Matter (4), Quantum Electrodynamics (5), Mathematical Physics (2), Cosmic Ray Physics (18), Elementary Particle Physics (14), Field Theory (15), General Physics (2), Nuclear Physics (4) and General (40). The highest number of publications (6) were published in 1941, 1945 and 1964 respectively. The average number of publications published per year was 3.05. His productivity coefficient was 0.05 which is a clear indicates that his publication productivity was quite consistent throughout his scientific career. He was single author in 79 of his publications and the main author in 24 publications indicates that he always preferred to work himself and lead the team as ‘mentor’. Bhabha had 22 collaborators during the period. Team of research collaborators working with a successful scientist documents the sociological aspect of history of science while generating knowledge by a leader in a domain.
Bhabha became a citable author in 1937. Bhabha received 1211 citations to his 30 publications out of 104 publications. Out of 104, 74 publications did not receive any citations. Out of 74 publications, 40 publications dealt subjects mainly of general interest. Bhabha’s 86.66 percent of cited publications received their first citations within four years of their publication indicates that his publications were noticed immediately and had direct impact among the fellow researchers working all over the world. His overall citation rate was 11.64 per cited publication. The highest citations 389 were received to the domain ‘Cosmic ray physics’. The highest number of citations received were 45 in 1938. His self-citations were only 24 (1.98%) and citations by others were 1187 (98.02%). The highest self citations were six in 1946. Bhabha’s mean diachronous self-citation rate was 1.98. The highest citation rate 28.4 was to the domain ‘Quantum electrodynamics. His single authored publications have received the highest number 863 (71.26%) of citations. Bhabha’s five publications have been cited more than 100 times each. His publications have been cited by the authors working in various diverse fields like nuclear physics, mathematical physics, instrumentation, optics, geophysics and geochemistry, condensed matter physics, applied physics, electrical and electronic engineering, mechanical engineering etc., indicating a very diverse influence and impact of Bhabha’s publications. Bhabha’s publications have also been cited by the Nobel laureates like V. L. Ginzberg, Wolfgang Pauli, H. A. Bethe, M. Born, W. Bothe, E. P. Wigner, H. Yukawa, P. M. S. Blackett and C. N. Yang which is an indication of his originality of ideas and high quality of publications
Scientometric portrait of Nobel laureate Leland H. Hartwell
No full textLeland H. Hartwell was honoured with the Nobel Prize in Physiology or Medicine (2001) at his 62 years age and at 41 years of research publishing career. The first contribution of the author was in 1961 at the age of 22. The number of his contributions in a year peaked in 1997 when it touched 8. He had 108 publications during 1961 – 2001 in domains: Molecular Biology of Cell Cycle Regulation (43), Genetics of Cell Division (48), Genomic Re-arrangement and DNA Repair (9), Molecular Genetics of Yeast Cell Fission (5), and Drug Target Interaction (3) which were analysed for authorship pattern with his 101 collaborators. Most active researchers having number of publications with Leland H. Hartwell were : Weinert, T. A. (10), Garvik, B. M. (8), McLaughlin, C. S. (8), Jenness, D. D. (5). His productivity coefficient was 0.76 which clearly indicates that his productivity increased after 50 percentile age. Highest collaboration coefficient (1) for Leland H. Hartwell was found during 1963-1965, 1968-1969, 1977, 1981-1983, 1985-1990, 1996 and 1998-2001. Journals have been the most preferred channel of communication where, as many as 96 papers out of 108 have been published. The core journals publishing his papers were: Cell (14), Genetics (12), Mol. Cell Biol. (8), J. Bactariol. (7), J. Cell Biol. ( 7), Science (7) J. Mol. Biol.(6), Exp. Cell Res. (5), and Proc. Nat. Acad. Sci.(5). Publication density is 2.63 and Publication concentration is 14.63. Most prolific keywords in titles of publications were: Saccharomyces cerevisiae , Yeast , Cell division cycle , RAD9, DNA Damage , Genes , Cell cycle, Genetic control , Check point (s) , Cell division , Mutant of Yeast
From Simple Mouth Cavities to Complex Oral Mucosal Disorders—Curcuminoids as a Promising Therapeutic Approach
No full text10.1021/acsptsci.1c00017ACS Pharmacology & Translational Scienc
Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
No full textCucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium
Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines
No full text10.1016/j.gene.2021.145421GENE77
Demystifying the Functional Role of Nuclear Receptors in Esophageal Cancer
No full textEsophageal cancer (EC), an aggressive and poorly understood disease, is one of the top causes of cancer-related fatalities. GLOBOCAN 2020 reports that there are 544,076 deaths and 604,100 new cases expected worldwide. Even though there are various advancements in treatment procedures, this cancer has been reported as one of the most difficult cancers to cure, and to increase patient survival; treatment targets still need to be established. Nuclear receptors (NRs) are a type of transcription factor, which has a key role in several biological processes such as reproduction, development, cellular differentiation, stress response, immunity, metabolism, lipids, and drugs, and are essential regulators of several diseases, including cancer. Numerous studies have demonstrated the importance of NRs in tumor immunology and proved the well-known roles of multiple NRs in modulating proliferation, differentiation, and apoptosis. There are surplus of studies conducted on NRs and their implications in EC, but only a few studies have demonstrated the diagnostic and prognostic potential of NRs. Therefore, there is still a paucity of the role of NRs and different ways to target them in EC cells to stop them from spreading malignancy. This review emphasizes the significance of NRs in EC by discussing their diverse agonists as well as antagonists and their response to tumor progression. Additionally, we emphasize NRs’ potential to serve as a novel therapeutic target and their capacity to treat and prevent EC
Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases
No full text10.1007/s00018-019-03053-0CELLULAR AND MOLECULAR LIFE SCIENCES76101947-196
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