3,070 research outputs found
Potential nutritional and pharmacological treatment of glycocalyx alterations during sepsis
No full textDuring sepsis, a combination of pathophysiological insults disrupts the glycocalyx. the thickness of the glycocalyx is correlated with parameters of disease severity, making it a potential new and independent target for therapeutic strategies in sepsis. The aim of this review was to examine potential beneficial effects of nutritional and pharmacological measures on glycocalyx alterations during sepsis and their timing. (Cite this article as: Pergolizzi c, Franchi F, taccone Fs, Preiser Jc, scolletta s. Potential nutritional and pharmacological treatment of glycocalyx alterations during sepsis. Minerva anestesiol 2023;89:341-50. Doi: 10.23736/s0375-9393.22.16834-3
Goal-directed Intraoperative therapy reduces morbidity and length of hospital stay in high-risk surgical patients
No full textAbstract: Background: Postoperative organ failures commonly occur after major abdominal surgery, increasing the utilization of resources and costs of care. Tissue hypoxia is a key trigger of organ dysfunction. A therapeutic strategy designed to detect and reverse tissue hypoxia, as diagnosed by an increase of oxygen extraction (0,ER) over a predefined threshold, could decrease the incidence of organ failures. The primary aim of this study was to compare the number of patients with postoperative organ failure and length of hospital stay between those randomized to conventional vs a protocolized strategy designed to maintain O2ER < 27%.
Methods: A prospective, randomized, controlled trial was performed in nine hospitals in Italy. One hundred thirty-five high-risk patients scheduled for major abdominal surgery were randomized in two groups. All patients were managed to achieve standard goals: mean arterial pressure > 80 mm Hg and urinary output > 0.5 mL/kg/h. The patients of the "pr..
Evaluation of innovative workplace design in the Netherlands
No full textOver the last decade many businesses are engaged in making organizational changes; adopting new management styles and ways of working. Concurrently, there has been a rise in the number of non-territorial “flexible” office designs based on job functions and work processes rather than individually assignedworkstations. Office buildings are becoming more ‘intelligent’ through the use of advanced building management systems, automatic indoor climate controls,innovative (day)lighting systems and so on. Such innovations in workplace design are intended to facilitate organizational change, improve user satisfaction, increase efficiency, and lower costs. To cope with the rapid innovation and changing nature of work environments, building environment-behaviour researchers in the Netherlands are developing ways to measure workplace performance.Accepted manuscriptReal Estate Managemen
Development of diagnostic tools for the detection of artemisinin resistance in the human malaria parasite plasmodium falciparum
No full textArtemisinin-based combination therapy (ACTs) remains the first-line treatment against
malaria infected by Plasmodium falciparum (P. falciparum). However, the spread of
artemisinin (ART)-resistant parasites in Cambodia and Thailand threatened the effectiveness
of ACTs. Till now, no molecular marker is found to be associated with the resistant
phenotype. Detection and tracking of resistant species proves to be a problem. Here, we
investigated on the possibility of using J-aggregate forming lipophilic cation 5,5',6,6'-
tetrachloro 1,1',3,3'- tetraethylbenzimidazolcarbocyanine iodide (JC-1) coupled with flow
cytometry to detect ART-sensitive or resistant parasites. Using sorbitol treatment, we generated synchronous ring stage parasites for our time-course assays. We showed that incubation time and ART concentration are the key parameters in detecting depolarization signal by JC-1. We also demonstrated that detection of depolarization signal by JC-1 remains a challenge in ART-treated parasite and thus may not be a useful diagnostic tool for detection of resistant species. This could be due to either the mechanism of ART, leading to rapid JC-1 loss or insensitivity of JC-1 on detecting the depolarization signal. Using an alternative strategy to detect ART resistance, we also identified changes of heat-shock protein 70 (CG4) protein expression across the life cycle of ART-sensitive 3D7 parasites by western blot analysis.Bachelor of Science in Biological Science
Perancangan Sistem Informasi Pengelola Barang/Inventaris Di Jc Komp
No full textInventory information system is a system used to enter inventory data into the database, so that there are no errors in input, output data, and reporting based on the desired data. based on surveys and interviews with jc comp personnel, information was obtained that the existing system in the jc comp warehouse section is still manual. therefore, the system that will be created by the author is the result of a replication of the existing system in the jc comp warehouse section. in addition to the process of input and output of goods, this information system is also equipped with features for creating data reports, input and output of goods, and searching for goods data by item name. with the inventory information system is expected to be useful for the warehouse parts jc comp. By implementing this system in the jc comp warehouse, it is hoped that it can reduce errors that may occur. this system is also expected to further speed up the process of input, output, and report generation, which in turn will help the jc comp warehouseSistem Informasi Persediaan Barang adalah sebuah sistem yang digunakan untuk memasukkan data-data persediaan barang ke dalam database, sehinggga tidak terjadi kesalahan dalam input, output data, dan pembuatan laporan berdasarkan data yang diinginkan. Berdasarkan survey dan wawancara dengan bagian personalia Jc Komp, didapatkan informasi bahwa sistem yang ada dibagian gudang Jc Komp masih manual. Oleh karena itu, sistem yang akan dibuat oleh penulis adalah hasil replikasi dari sistem yang telah ada dibagian gudang Jc Comp. Selain proses input dan output barang, pada sistem informasi ini juga dilengkapi fitur pembuatan laporan data, input, dan output barang, dan pencarian data barang berdasarkan nama barang. Dengan adanya Sistem Informasi persediaan barang ini diharapkan dapat bermanfaat bagi bagian gudang Jc Komp. Dengan diterapkannya sistem ini pada bagian gudang Jc Comp, maka diharapkan dapat mengurangi kesalahan-kesalahan yang mungkin terjadi. Sistem ini juga diharapkan dapat lebih mempercepat proses input, output, dan pembuatan laporan yang pada akhirnya dapat membantu bagian gudang Jc Komp
Amenable L-2-Theoretic Methods and Knot Concordance
No full textWe reveal new structures in the topological knot concordance group. As a key ingredient, we develop obstructions using L-2-theoretic methods for amenable groups in Strebel's class recently introduced by Orr and the author. Concerning (h)-solvable knots, which are defined in terms of certain Whitney towers of height h in bounding 4-manifolds, we show the following: for any n>1, there are (n)-solvable but non-(n. 5)-solvable (and therefore nonslice) knots, which are not detected by prior methods using Cochran-Orr-Teichner L-2-signature obstructions as well as Levine algebraic obstructions and Casson-Gordon invariants.X1197sciescopu
Dynamics of Network Formation Processes in the Co-Author Model
No full textThis article studies the dynamics in the formation processes of a mutual consent network in game theory setting: the Co-Author Model. In this article, a limited observation is applied and analytical results are derived. Then, 2 parameters are varied: the number of individuals in the network and the initial probability of the links in the network in its initial state. A simulation result shows a finding that is consistent with an analytical result for a state of equilibrium while it also shows different possible equilibria.Dynamics, Network, Game Theory, Model,Simulation, Equilibrium, Complexity
High-level polyomavirus JC viruria following long-term steroid therapy
No full textCASE REPORT JC virus is a highly seroprevalent ubiquitous polyomavirus which is acquired at an early age through respiratory or oral route, Thereafter JCV establishes persistent, but mainly asymptomatic, infections in various tissues, including the genitourinary tract and brain Corresponding author Cristina Costa, MD S.C.D.U. Virologia Azienda Ospedaliero-Universitaria San Giovanni Battista di Torino Via Santena, 9 -10126 Torino E-mail: [email protected] increasing with age, with adult prevalence rate often between 15% and 60
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