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Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction
Get PDFSirman Y. V., Preis N. I., Savytskyi I. V. Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction. Journal of Education, Health and Sport. 2021;11(10):411-422. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.10.038
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.10.038
https://zenodo.org/record/6449122
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
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provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
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The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 30.09.2021. Revised: 12.10.2021. Accepted: 29.10.2021.
UDC:616-06:616-092.9
RESEARCH OF CHANGES IN THE LEVEL of ENDOTHELIN-1 IN EXPERIMENTAL DIABETIC RETINOPATHY. COMPARISON OF METHODS OF CORRECTION
Y. V. Sirman, N. I. Preis, I. V. Savytskyi
SE "Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine"
Abstract
Diabetic retinopathy (DR) according to the WHO is the main cause of decreased vision and blindness due to diabetes.
The aim of the study: to compare the effectiveness of correction of vasoconstriction in experimental diabetic retinopathy under the influence of different methods of correction.
Our results indicate a violation of the functional state of blood vessels on the 30th day of experimental diabetic retinopathy with subsequent progression of pathological changes on the 60th and 180th day of the study, as evidenced by a significant increase in endothelin-1 in the 2nd group (p <0.001), most pronounced in the 3rd stage.In the analysis of data of group №3 it was found that the correction of pathological conditions with hypoglycemic agents has a positive effect, but does not allow to significantly correct pathologically increased levels of endothelin-1, which indicates the need for additional correction tools other than hyperglycemia.The results of group 4 indicate that the involvement of a donor of nitric oxide and aflibercept in the correction of diabetic retinopathy corrects the level of the studied marker, the most pronounced effect is observed on the 180th day of the experiment, but normative values can not be achieved. It was found that in the 5th group, in which the correction of the simulated pathological condition was performed by reducing hyperglycemia, the introduction of aflibercept and bromfenac gives positive results, but less pronounced than in the 4th group, where L-arginine solution was added to the complex correction. .It was found that rats of group 6, which simulated diabetic retinopathy with subsequent correction of hyperglycemia, administration of aflibercept, L-carnitine and bromfenac have a pronounced effectiveness of the proposed method of correction compared to previous methods, the level of vasoconstriction stage and continues to recover in the following stages of the experiment, but does not reach the normative values. The obtained data suggest that the method of correction selected in group 7, which includes reduction of hyperglycemia, administration of aflibercept, solution of L-arginine and citicoline is most effective for normalizing vascular tone and structural and functional state of the endothelium.
Key words: experimental diabetic retinopathy; endothelial dysfunction; endothelin-1; vasoconstriction; correction
Characterizing the time-perspective of nations with search engine query data
Get PDFVast quantities of data on human behavior are being created by our everyday internet usage. Building upon a recent study by Preis, Moat, Stanley, and Bishop (2012), we used search engine query data to construct measures of the time-perspective of nations, and tested these measures against per-capita gross domestic product (GDP). The results indicate that nations with higher per-capita GDP are more focused on the future and less on the past, and that when these nations do focus on the past, it is more likely to be the distant past. These results demonstrate the viability of using nation-level data to build psychological constructs
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Davidde penitente
No full textvon W.A. Mozart ; Im Clavierauszuge von C. ZulehnerIndividualtitel in der Vorlage mit doppelten Anführungsstrichen.Vorlageform der Veröffentlichungsangabe: Bonn bei N. Simrock. ; Preis der drei Singstimmen allein 75 Cs ; Preis 2 Francs.Bibliographischer Nachweis: RISM A/I: M 4175 ; KV, Seite 788.Lithographie [Titelblatt] ; Plattendruck [Notentext
Thamos, König in Aegypten
No full textMusik von W. A. Mozart. Im Clavierauszug von C. ZulehnerBibliogr. Nachweis: RISM A/I: M 5248Vorlageform des Erscheinungsvermerkes: No. 1180. Bonn und Cöln bei N. Simrock ; Preis 2 Fr
Kanons Singstimme (4)
No full textcomposé par W. A. MozartKV 557Bibliogr. Nachweis: RISM A/I: M 5498 ; KV, S. 628 ; Haberkamp, Erstdrucke Bd. 1, S. 314Vorlageform des Erscheinungsvermerks: À Bonn chez N. Simrock. [hs.: Preis 50 c]PlattendruckText ital
Xenicola taroba Fianco & Preis & Szinwelski & Braun & Faria 2019, sp. n.
No full textXenicola taroba Fianco, Faria & Braun sp. n. (Figs. 6, 9 A–D, 10C and 11C) Diagnosis: This species can by recognized by fastigium of frons at most a sixth of the scape width; CuP black; superior spine of all genicular lobes at least three times longer than the inferior one; tergite X with a protuberance equal to one third of the tergite; subgenital plate wider than long; cerci curved, thickness tapering towards their apical curvature, then becoming abruptly narrow; lower fold of ventral lobe of male genitalia trespassing the ventral fold of dorsal lobe. Female ovipositor twice as long as pronotum. Etymology: In the legend of how the Iguazu Falls were created (e.g. Carneiro Jr. 2005), Tarobá, a young warrior, and his beloved Naipí were punished by M’Boi, the serpent god, son of Tupã. In his anger against Tarobá and Naipí, that were trying to escape on a canoe, M’Boi dug the riverbed, forming these astonishing falls. The specific epithet honors Tarobá, this curious legend and all the native people of trinational region (Argentina, Brazil and Paraguay). Noun in apposition. Description: Holotype male (Fig. 6 A–E; 9A, C; 11C): Head (Fig. 6C, D): Fastigium of frons at most a sixth of the scape width. Sulcus of fastigium of the vertex as long as diameter of the eye. Antennae at least three times as long as the body; scape dorsoventrally flattened; pedicel cylindrical. With a brown strip from eye in direction to pronotum. Thorax: Pronotum: pronotal disc pubescent, setae arising from existing granulations; Lateral lobes with a curved sulcus in the middle, below lateral carina; pubescent, without granulations; lateral carinae with an uninterrupted straight tricolour band from anterior to posterior edge, yellow-white-light brown pattern from top to bottom; inferior edge undulated, posterior edge straight, in a 45º angle in relation to pronotal disc (Fig. 6D). Wings (Fig. 9A, C): Tegmina rounded (Fig. 9A); CuP black; teeth of stridulatory file almost with the same size, intertooth interval broader in in the middle (Fig. 9C). Legs: Legs I and II light brown, leg III darker. Extremities of tibia and femur light yellow. Superior spine of genicular lobe at least three times longer than the inferior. Abdomen: tergites with several granulations, specially medially. Tricolour band also present, seen only laterally; yellow-white-brown from top to bottom (Fig. 6A). Tergite X with posterior edge concave; with a protuberance equal to one third of the tergite (Fig. 6F). Subgenital plate elliptical, wider than long; median keel not longer than half length of the plate; posterior processes longer than wide (Fig. 6E). Cerci curved, thickness decreasing gradually to their apical curvature, becoming abruptly narrow; with a dark apical tooth (Fig. 6F). Genitalia (Fig. 11C): Phallus symmetrical, rounded; ejaculatory vesicles small, in the middle of the base of the dorsal lobe; lower fold of ventral lobe chalice-shaped, apex rounded, trespassing the ventral fold of dorsal lobe; upper folds of ventral lobe as long as half of its lower fold; ventral fold of dorsal lobe smooth in dorsal view, apical edge almost straight; dorsal lobe tip acuminate and with dot-like sclerotizations; dorsal lobe without amorphous sclerotization; dorsal fold narrow, in width at most a quarter of lower fold of ventral lobe. Calling song: unknown. The only male was collected in a Malaise trap, in alcohol. Female (Figs. 6G, H; 9B, D; 10C): Larger than male (Fig. 10C). Most morphological structures as in males. Maxillary palps light green. Pronotum surface smooth. Spatula-like forewings (Fig. 9F), the right with one almost straight line of conical stridulatory teeth, as large as long, the line curving ca. 50º and forming a F-like vein with several longer teeth (Fig. 9D). Lateral lobes of pronotum with a plain light band, from anterior to posterior edge; tricolor band absent. Abdomen greenish with a lateral white band. Tergite X at least half as long as IX; posterior edge undulated with a median depression; without any protuberance. Conical cerci, as long as epiproct. Subgenital plate triangular with obtuse apex; its base at least four times as wide as apex (Fig. 6G). Ovipositor twice as long as pronotum, almost straight; acuminate; serrulations from the distal fourth of dorsal valves and in the distal fifth of inferior valves (Fig. 6H). This description corresponds to the paratype listed below. Type material: Holotype male “ BR, PR, Foz do Iguaçu\Parque Nacional do Iguaçu\ 11–17.XI.2017 \Malaise 5m \ Szinwelski, N. col.”. Deposited at “Coleção Entomológica Padre Jesus Santiago Moure” (DZUP), Curitiba, Brazil. Paratype: 1 female, “ BR, PR, Foz do Iguaçu\Parque Nacional do Iguaçu\ 06–09.IX.2017 \Coleta ativa noturna\ Fianco, M. col.”. Deposited at “Coleção Entomológica Padre Jesus Santiago Moure” (DZUP), Curitiba, Brazil. Measurements (mm): Holotype: BL: 14.72; TegL: 2,73; HW: 3.07; PrL: 3.51; PrH: 2.4; LFiii: 19.5; LTiii: 24; SPL: 1.77; CL: 2.27; SPL: 0.83; TN: 34. Paratype: BL: 19.67; TegL: 2.46; HW: 3.62; PrL: 4.52; PrH: 2.06; LFiii: 23.47; LTiii: 27.71; SPL: 1.81; CL: 1.68; CO: 11.32; SFL: 0.64; TN: 19. Remarks: At first, it is important to highlight that the holotypes of Xenicola dohrni and Xenicola superba were both studied through photographs kindly provided by Dr. P.D. Szymroszczyk, curator of MZPW. Xenicola taroba sp. n. is similar to X. dohrni and X. xukrixi sp. n. as the males of both species present a tricolour band on lateral lobes of pronotum; despite being collected in a Malaise trap (and fixed and stored in alcohol), we were able to perceive some colour markings in the specimen. The similarities are also in the shape of lateral edges of pronotum, curved tip of male cerci and in the spatula-like tegmina. Both X. dohrni and X. taroba sp. n. have broad lateral lobes of the pronotum compared to a narrow one in X. superba. The new species differs from X. superba by having a smooth lateral carinae of the pronotum, compared to the crenelated shape in this latter species. Another difference is the shape of the inferior edge of the lateral lobes of pronotum, curved in X. taroba sp. n. and straight in X. superba, and in the angulation of posterior edges, very oblique in X. superba and in just 45º in the new species and in X. dohrni. The new species, X. taroba sp. n., is distinguished from X. dohrni by the shape of male cerci, that are curved and have a suddenly narrowed tip compared to being straight and of almost the same thickness in X. dohrni, and in the length of the subgenital plate, much more longer than cerci in the new species and longer than cerci in X. dohrni. The differences between females of Xenicola are related to general coloration, a plain colour in X. superba in contrast to a presence of a white strip on lateral sides of abdomen and pronotum in X. taroba sp. n. The tegmina in the new species are spatula-like as in X. dohrni, very distinct of the truncated tegmina of X. superba, and not presenting the pallid reticulations as found in X. superba. The ovipositor size is also different among the species, twice as long as pronotum in X. superba, and 2.5x in the new species.Published as part of Fianco, Marcos, Preis, Hemanueli, Szinwelski, Neucir, Braun, Holger & Faria, Luiz R. R., 2019, On brachypterous phaneropterine katydids (Orthoptera: Tettigoniidae: Phaneropterinae) from the Iguaçu National Park, Brazil: three new species, new record and bioacoustics, pp. 240-264 in Zootaxa 4652 (2) on pages 251-253, DOI: 10.11646/zootaxa.4652.2.2, http://zenodo.org/record/336373
Strategic Impacts of Technology Switch-Over: Who Benefits from Electronic Commerce?
Get PDFThe introduction of new digital production and distribution technologies may alter the firms' strategy sets, as they are not able to commit credibly to quantity strategies anymore. Mixed oligopoly markets may emerge where some companies compete in prices, while others adjust their quantities. Using an approach first published by Reinhard Selten (1971) and developed further by Richard Cornes and Roger Hartley (2001), I calculate the Nash equilibrium of such an N-person game in a linear specification. Then I discuss the strategic effect of a technology switch-over on market performance and social welfare. A firm that introduces new technology suffers a srategic disadvantage, while consumers benefit.electronic commerce, oligopoly theory, product differentiation
Stably stratified shear-produced turbulence and large-scalewaves in a lid driven cavity
No full textWe study experimentally stably stratified sheared turbulence and large-scale flows and waves in a lid driven cavity with a non-zero vertical mean temperature gradient. Geometrical properties of the large-scale vortex (e.g., its size and form) and the level of small-scale turbulence inside the vortex are controlled by the buoyancy (i.e., by the temperature stratification). The observed velocity fluctuations are produced by the shear of the large-scale vortex. At larger stratification obtained in our experiments, the strong turbulence region is located at the upper part of the cavity where the large scale vortex exists. In this region the Brunt-Väisälä frequency is small and increases in the direction outside the large-scale vortex. This is the reason of that the large-scale internal gravity waves are observed in the regions outside the large-scale vortex. We found these waves by analyzing the non instantaneous correlation functions of the temperature and velocity fields. The observed large-scale waves are nonlinear because the frequency of the waves determined from the temperature field measurements is two times smaller than that obtained from the velocity field measurements. The measured intensity of the waves is of the order of the level of the temperature turbulent fluctuations
Offertorium de tempore
No full textin Musik gesetzt von W.A. MozartKV 222Vorlageform der Veröffentlichungsangabe: Bonn und Cöln bei N. Simrock. ; Preis 3 Frs: 50 C..sBibliographischer Nachweis: RISM A/I: M 4131 ; KV, Seite 228 ; Whistling (1823), Seite 84PlattendruckText lateinisch und deutsc
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