86,930 research outputs found
A note on a Heegaard diagram of S^3
No full textOchiai describes a Heegaard diagram of S^3, with a particular associated fundamental group presentation H.This Heegaard diagram has neither waves nor pairsof complementary handles, so it is directly reducible neither by awave-move , nor by a Singer's move of type III'. Hence it is a counterexample to theWhitehead's conjecture and to the algorithm A ofVolodin-Kuznetsov-Fomenko.We construct a crystallization of S^3 having H as an associated presentation of the fundamentalgroup with respect to a suitable choice of generators and relatorsand such that Ochiai's Heegaard diagram is one among the Heegaard diagramsassociated to the crystallization.Moreover, we prove that at least one among the remaining Heegaarddiagrams associated to our crystallization hassome pairs of complementary handles, and so it is directly reducibleby Singer's move of type III' to the canonical diagram ofS^3
I bacini ceramici di S. Ambrogio Vecchio a Varazze: produzione, provenienza e degrado. Studio campione di un contesto ligure,
No full textTen-years longitudinal study of thyroid function in children with Down syndrome.
No full textBackground: Children with Down syndrome (DS) show an increased prevalence of thyroid disease when compared with the general population. The risk for thyroid dysfunction rises with age. A yearly thyroid screening was suggested in the guidelines of the American Academy of Pediatrics for the health supervision of children withDS.Objective and hypotheses: The aim of our investigation is to longitudinally study the thyroid function in children with DS in order to identify the prevalence of thyroid pathology throughout development.Methods: Thyroid function tests were yearly carried out on 120 children with DS, all followed from birth to 10 years of age. There were 65 boys and 55 girls. Subjects were annually classified according to thyroid function as: normal, congenital hypothyroidism (C-HT), hypothyroidism (HT - TSH >10 mcIU/ml and low FT4), subclinical hypothyroidism (S-HT - TSH between 5 and 10 mcIU/ml and normal FT4), hyperthyroidism (HyperT).Results: In our study population the prevalence of normal thyroid function significantly decreased from 90.8% to 41.7% throughout 10-years follow-up. Therefore, the prevalence of thyroid dysfunctions increased, in particular the HT ones. The abnormal findings were almost equally distributed between the genders.Conclusions: More than half of the children with DS in our study developed thyroid dysfunctions. Our results confirm that DS patients, especially those with normal thyroid function and subclinical hypothyroidism, should be carefully followed annually to precociously identify the appearance of thyroid pathology and to begin an adequate hormonal treatment.presentation
Copper complexes grafted to functionalized silica gel as wood preservatives against fungal decay: mini-blocks and standard test
No full textIl controllo dell’appetito
No full textAppetite control is executed through the fi ne regulationbetween calories and energy expenditure, in the dailyexperience of hunger and fulfi llness. Nowadays thedisregulation of this system is frequent, due to the increasedfood availability and through the interaction with environmental factors that determine hyperfagia and can cause obesity.This regulation system is constituted of peripheral nervous system, gastrointestinal system, endocrine system and of adipose tissue that integrate in central nervous system and in particular in hypothalamus, creating an homeostatic system.The comprehension of physiological processes that modulate body weight is necessary to establish therapies for this problem wherediet is often ineffectiv
L’ipercolesterolemia familiare: terapia farmacologica
No full textNei casi di dislipidemia d’origine genetica, spesso associati a gravi quadri di morbilità e mortalità cardio-vascolari già in giovane età, la diagnosi e il trattamento precoci risultano cruciali per prevenire o ritardare le complicanze. a dieta, povera di grassi saturi e di colesterolo, deve essere considerata il primo approccio terapeutico nei bambini di età superiore ai 2 anni con ipercolesterolemia ; essa garantisce infatti il mantenimento di un apporto nutrizionale adeguato alla crescita e al regolare sviluppo puberale. Si consiglia di limitare l’uso dei farmaci ipocolesterolemizzanti ai pazienti di età superiore ai 10 anni in cui la dieta, seppur severa, non sia efficace, soprattutto se sono presenti più fattori di rischio cardiovascolari. Ad oggi, tra tutti i farmaci ipocolesterolemizzanti, solo le resine sequestranti acidi biliari sono raccomandate nell’infanzia e nell’adolescenza. La loro scarsa palatibilità limita la compliance alla terapia in età pediatrica. Sempre maggiore è l’interesse verso le statine. Gli studi presenti in letteratura sull’efficacia e la sicurezza delle statine in pediatria danno risultati positivi, seppur condotti su casistiche limitate e prendendo in esame solo gli effetti avversi a breve termine. Recentemente un nuovo farmaco, ezetimibe, sembra efficace e sinergico all’attività terapeutica delle statine. Questa revisione si propone di segnalare le più recenti acquisizioni sulla diagnosi, la terapia e il follow-up dell’ipercolesterolemia familiare in età pediatrica
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