1,721,040 research outputs found
Metabolic effects of long-term thiazolidinedione treatment in insulin resistance
No full textLong-term pioglitazone treatment of rats ameliorates dyslipidemia and insulin resistance in muscle and adipose tissue. Gradual decrease in serum insulin levels during therapy suggest positive effects on hyperinsulinemia and a possibilty to prevent type 2 diabete
Identification of the genetic determinant of insulin resistence by comparative gene sequencing
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Identification of the genetic determinant of insulin resistence by comparative gene sequencing
No full textÚstav biologie a lékařské genetiky 1.LF UK a VFN v PrazeInstitute of Biology and Department of Medical Genetics First Faculty of Medicine Charles UniversityFirst Faculty of Medicine1. lékařská fakult
Quantificaion of Plzf expression in a rat model of hypertension and metabolic syndrome
Get PDFMultifactorial diseases like hypertension or metabolic syndrome are significant causes of morbidity and mortality. The metabolic syndrome is mostly characterized by resistance to insulin effect, impairment of lipid metabolism and inclination to hypertension and obesity. Essential hypertension which is the part of the metabolic syndrome is widely spread all over the world and presents the main risk factor for coronary diseases, kidney failure, and stroke. Inbred animal models can be used for identification of the genetic component of complex diseases. The most studied model of metabolic syndrome and essential hypertension is the spontaneously hypertensive rat (SHR), which has proven to be a valuable tool for studying the pharmacological and physiological aspects of blood pressure regulation. There has been significant progress during the last decades in genetic mapping of hypertension and other complex traits in rat models, including SHR. Many of these quantitative trait loci - QTLs are involved in pathogenesis of spontaneous hypertension with the effect on the blood pressure variation about 10-20 mmHg. One QTL involved in blood pressure regulation is located on the rat 8th chromosome. This QTL has been confirmed by the congenic strain SHR-Lx. In this strain the 7-gene 788 kb segment of chromosome 8 of SHR..
Analysis of cognitive functions in recombinant inbred strains of rats produced by crossbreeding of SHR and BN Lx. lines
No full textThis MSc. thesis deals with dissecting the link between memory, genetics, and metabolic syndrome. Memory is a very complex behavioral trait, probably influenced by innumerable factors. For this experiment HXB/BXH rat recombinant inbred lines (n= 30) and their parental strains (n=2) were used to be trained in the hippocampus dependant spatial learning task called Allothetic Active Place Avoidance. Rats were to memorize sector of a rotating circular arena, which they were to avoid, being motivated by receiving an electric shock upon entering the forbidden sector (4 training sessions; shock sector on the North, 1 retrieval session (no shock), and 3 reversal sessions, to-be-avoided sector facing South; each session 20-min long, retrieval 10-min). Control experiments to exclude impact of motor or sensory abnormalities were run in a form of open-field test and beam-walking test. Correlation with metabolic phenotypes was conducted in an online database of known HXB/BXH phenotypes (GeneNetwork.org). The results showed that differences in learning were significant between the groups (p<0.05); correlation analysis indicated no putative link between selected traits related to metabolic syndrome and memory in rats. The genetic analysis showed a suggestive locus on chromosome 20 for a learning parameter, and..
Genetic determination of insulin resistance and hyperglyceridemia in model rat congenic strains
No full textInstitute of Biophysics and Informatics First Faculty of Medicine Charles University in PragueÚstav biofyziky a informatiky 1. LF UK v PrazeFirst Faculty of Medicine1. lékařská fakult
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
- …
