5 research outputs found
Inter relationship of plasma lipid profile parameters with plasma uric acid levels in psoriasis
No full text<p class="abstract"><strong>Background:</strong> Psoriasis is a chronic immune mediated skin disease accompanied with disturbances in systemic lipid turnover. Hyperuricemia has been frequently observed as an additional complication in psoriasis. The relationship between the raised plasma lipid parameters and the uric acid levels in psoriasis need to be ascertained. A study was undertaken to assess the possible relationship of plasma lipid parameters with plasma uric acid levels in psoriasis and to relate any such relationship to psoriasis disease severity.</p><p class="abstract"><strong>Methods:</strong> Non arthritic psoriasis patients were randomly selected and were grouped into mild (Group 1), moderate (Group 2) as well as severe (Group 3) based on their PASI scores.<strong> </strong>Plasma lipid parameters and uric acid levels were assessed in these patients.<strong></strong></p><p class="abstract"><strong>Results:</strong> The results show a significant (p&lt;0.001) parallel raise in plasma uric acid levels along with plasma lipid parameters<strong> </strong>with the severity of disease in these patients.</p><p class="abstract"><strong>Conclusions:</strong> A plasma uric acid level along with plasma total cholesterol and triacylglycerol levels<strong> </strong>fetch much information on the severity of psoriasis disease.</p><p class="abstract"> </p></jats:p
Effect of diallyl disulphide on hepatic glucose regulating enzymes in diabetic rats
No full text567-571This study examines whether the glucose regulating enzymes mediate hypoglycaemic effect of diallyl disulphide (DADS) since the biochemical mechanisms by which the latter regulates hepatic glucose-metabolizing enzymes remain unknown. Hepatic hexokinase, glucose-6-P-D and pyruvate kinase are the important glucose metabolising enzymes that control blood glucose homeostasis and considered to be potential targets for antidiabetic drugs. DADS is an important phytoconstituent of garlic (Allium sativum Linn.) which has been reported to possess hypoglycaemic effect. Diabetes was induced in rats by alloxan and the diabetic rats were given DADS for 30 days and the effect was compared with the standard hypoglycaemic drug metformin. The levels of blood glucose and insulin were measured using spectrophotometer and by ELISA method respectively. Activities of hepatic hexokinase, glucose-6-PD, and pyruvate kinase enzymes in hepatic tissues were measured in DADS and metformin treated diabetic rats. DADS significantly reduced the level of blood glucose and simultaneously augmented those of insulin, pyruvate kinase, hexokinase and glucose-6-PD enzyme activities almost similar to metformin. The hypoglycaemic effect of this compound may be explained, in part, by its inhibition of these enzyme activities and improved hepatic glucose utilization. This observation offers scope for new therapeutic approach in treating diabetes particularly in insulin- resistant cases
Expectant Mothers with Iron Deficiency Anemia: Correlation Between Oxidative Stress, Erythrocyte Indicators, and Iron Stores
No full textIntroduction: Iron deficiency anemia is a common condition in pregnant women, associated with adverse maternal and fetal outcomes. Oxidative stress, indicated by elevated malondialdehyde (MDA) levels, may exacerbate anemia by damaging red blood cells and impairing iron metabolism. This study aims to explore the relationship between oxidative stress, measured through serum MDA levels, and hematological indices, including hemoglobin and ferritin, in pregnant women diagnosed with iron deficiency anemia. By comparing these parameters with healthy pregnant and non-pregnant controls, we seek to enhance understanding of the mechanisms underlying anemia during pregnancy and identify potential targets for intervention.Materials & Methods: The study included 75 women aged 20 to 40 years, comprising 25 cases of iron deficiency anemia during pregnancy, 25 healthy pregnant controls, and 25 healthy non-pregnant controls. Blood samples (10 ml) were collected for hemoglobin, MCH, MCHC, serum ferritin, and MDA analysis. Statistical analysis was performed using ANOVA and Pearson\u27s correlation.Results: MDA levels were significantly elevated in anemia cases (6.96 ± 1.69) compared to pregnant controls (4.63 ± 1.55) and healthy controls (3.65 ± 1.08), indicating increases of approximately 50.3% and 90.0%, respectively. Serum ferritin levels were markedly reduced in anemia cases (8.3 ± 7.94 ng/ml) compared to pregnant controls (39.10 ± 13.68 ng/ml) and healthy controls (61.05 ± 25.29 ng/ml). Hemoglobin, MCV, MCH, and MCHC were also significantly decreased in anemia cases compared to both control groups.Discussion: The findings highlight a strong association between elevated oxidative stress, indicated by increased MDA levels, and reduced iron stores in iron deficiency anemia during pregnancy. This study underscores the importance of monitoring oxidative stress and iron levels to manage anemia effectively
