4 research outputs found
A COMPREHENSIVE REVIEW ON IN SITU GELS
No full textThe current review on in situ gelling systems becomes one of the most popular and prominent. It had a tremendous potential advantage of delivery systems due to many benefits like easy to use simple manufacturing; improve both adherence and patient comfort by minimizing the frequency of drug administration by its unique characteristics feature of sol to gel transition. It also provides in situ gelling nanoemulsions, nanosphere, microspheres, and liposomes. The drawbacks associated with conventional systems of both solutions and gels, such as accurate dosing, ease of administration overcome by using in situ gelling systems. This review focused on definitions, types, advantages, disadvantages, polymers used, and suitable characteristics of polymers, including the preparation of in situ gels covered in the introduction. Approaches, applications, and evaluation of in situ gels were explained with examples
Phytochemical and pharmacological overview on Paerida foetida L. and Sphaeranthus amarnthoides Burm.f.: A Review
No full textThe phytochemistry and pharmacological activities of the plants Paerida foetida L. and Sphaeranthus amaranthoides Burm.f. are the goals of this review. The current study\u27s findings are supported by the review literature and published research on the pharmacological and phytochemical characteristics of Sphaeranthus amaranthoides Burm.f. and Paerida foetida L. These plants are useful for antibacterial, anthelmintic, antioxidant, cytotoxic, anti-diabetic, hypolipidaemic, and hepatoprotective effects. The plant extracts were regarded as safe for animals according to toxicity studies. Both plants contain a variety of phytoconstituents, including tannins, terpenoids, steroids, phenols, flavonoids, and saponins, each of which has a distinct pharmacological action. For many years, people have been exploring the natural world to find novel phytoconstituents that have been employed in the treatment of various illnesses. It also offers a way to discover novel semisynthetic and synthetic molecules as well as new natural entities. This review article examines the claims, traditional knowledge, and phytochemical and pharmacological analyses of these plants, as well as their potential uses in the future
Transforming Drug Discovery and Development:The Impact of Artificial Intelligence
No full textArtificial intelligence (AI) is revolutionizing the drug development process, transforming the entire process. AI can help researchers find drug candidates faster, conduct clinical trials more efficiently, improve manufacturing processes, and expand market access options. It can speed up the first phases of drug discovery by facilitating quick screening of candidate compounds by anticipating interactions between molecules and target proteins. AI also plays a significant role in the successful repurposing of drugs by finding new therapeutic applications for medications approved for other purposes.Predictive toxicology is another area where AI is having a major impact. By predicting probable toxicities and side effects of drug candidates using AI, late-stage failures are reduced and patient safety ensured. AI is also reshaping trial methodology and patient recruiting in clinical trials, reducing costs and improving success rates.AI also helps the pharmaceutical industry deal with increasingly complicated regulatory environments by deciphering and analyzing regulatory documents and recommendations to ensure conformity with ever-changing norms. This capacity accelerates the regulatory approval process, allowing the introduction of new pharmaceuticals to the market.Despite the challenges, AI has had far-reaching and complex effects on the pharmaceutical industry. With the help of AI, the pharmaceutical industry can speed up the discovery of new drug ideas, improve the effectiveness of clinical trials, streamline production, and hone its approach to market access. The payoff for patients and the pharmaceutical business could be enormous.
DOI: https://doi.org/10.52783/jchr.v13.i4.130
Design, optimization, and characterization of Zolmitriptan loaded liposomal gels for intranasal delivery for acute migraine therapy
No full textZolmitriptan is the primary drug for the treatment of Migraine. However, the bioavailability of the drug is low and requires repetitive administration leading to side effects. Zolmitriptan's bioavailability can be improved by incorporating it into liposomes as a topical intranasal gel. The formulation was developed using a Central composite design employing a response surface approach. The new formulations were tested for particle size, shape, drug entrapment efficiency, and in vitro drug release. Permeation experiments and histopathology in rats were also conducted to determine the formulation's safety. The vesicle size was found to be in the range of 103.82 ± 7.16 to 694.38 ± 1.02 nm, zeta potential --19.28 to −32.8 mV, Entrapment Efficiency from 55.49 ± 1.37 to 99.12 ± 0.36 %, and cumulative drug release from 59.71 ± 6.94 to 99.38 ± 0.13 % respectively. In-vitro drug release of G1 and G3 gel formulations showed a non-Fickian released pattern during the studies. A comparison of the permeation coefficient of G1 (0.539 μg/cm2) and G3 (5.3 μg/cm2) showed a slight variation in the drug release rate after 24 h. For the liposomal gel and its solution, we found a significant difference in drug penetration of p0.05 after 12 h compared to the control gel. There were substantial differences in bioavailability and pharmacokinetics between the optimal Liposomal Gel Formulation and other formulations, including the drug solution, liposomal suspension, and optimized formulation F12. The liposomal gel is non-irritating and safe for topical administration by histopathological investigations. Therefore, the study demonstrated that Zolmitriptan Liposomal gel has better efficacy, good tolerability, and enhanced bioavailability, making it an optimal treatment for acute Migraine
