11 research outputs found
Perencanaan Arsitektur Gedung Gelanggang Olah Raga (GOR) Politeknik Negeri Bengkalis
No full textIn general, each university has its own Sports Center Building which functions as a sports center for students and academics. As the number of students increases and academic activities increase, the need for adequate supporting facilities also increases. One of the facilities that is needed is the Sports Arena Building (GOR).
The method used in this final assignment uses qualitative analysis which is explained descriptively regarding the plans that will be designed to make it easier to design 2-dimensional and 3-dimensional images. The planning for the Sports Arena Building is based on the guidelines of the Minister of Youth and Sports Regulation No. 5 of 2019.
The design results in this design plan have met the criteria for an effective and targeted design that has a modern appearance and contains elements around the planning location, namely waves or waves, the use of wave or wave elements on the facade of this building because the location of this building is on Bengkalis Island. which is surrounded by a vast ocean that has waves or waves. Later, this image design can become a reference in the construction of the Sports Arena Building (GOR) in the future
La atención temprana y su aplicación en Navarra
No full textDurante este trabajo de investigación se han explicado conceptos importantes
relacionados con la Atención Temprana y la evolución histórica que ha tenido. Se ha
hecho hincapié en los aspectos que son importantes para realizar una Atención
Temprana adecuada con niños y niñas que presentan alteraciones o trastornos en el
desarrollo. En una segunda parte de este trabajo, se ha desarrollado como se trabaja la
Atención Temprana en Navarra y los distintos recursos destinados a ello. En un tercer
apartado se han comparado los distintos aspectos tratados durante el trabajo de
investigación acerca de la AT, a nivel general, con su concreción en la Comunidad Foral
de Navarra. Para finalizar, se hace con un apartado donde el autor saca sus conclusiones
acerca del trabajo realizado.During this research work, important concepts related to Early Attention and historical
evolution have been explained. Emphasis has been placed on the aspects that are
important for proper Early Attention with children with developmental disorders. In a
second part of this work, have been developed the Early Attention in Navarre and the
resources destined for it. In a third section has compared different aspects discussed
during the research work on Early Attention, generally, with as reference is made to
them in the Foral Community of Navarre. Finally, it is done with a section where the
author draws his conclusions about the work done.Graduado o Graduada en Maestro en Educación Infantil por la Universidad Pública de NavarraHaur Hezkuntzako Irakasletzan Graduatua Nafarroako Unibertsitate Publikoa
1137 years of high-resolution Continuous Flow Analysis impurity data from the Mount Brown South Ice Core
No full textProgress Code: completedStatement: A revised dataset with minor corrections was submitted on 2025-06-06.Abstract: The Mount Brown South ice core (MBS 69.111 S, 86.312 E) is a new, high resolution ice core drilled in coastal East Antarctica. With mean annual accumulation estimated to be 20-30 cm ice equivalent accumulation throughout the length of the core (~295 m), MBS represents a high resolution archive of ice core data spanning 1137 years (873 - 2009 CE), from an area previously underrepresented by high resolution ice core data. <br/><br/>Here, we present a high-resolution dataset of chemistry and impurities obtained via continuous flow analysis (CFA), measured at the Physics of Ice, Climate, and Earth at the Niels Bohr Institute, University of Copenhagen. The dataset consists of meltwater electrolytic conductivity, sodium (Na+), ammonium (NH4+), hydrogen peroxide (H2O2), and insoluble microparticle measurements. The data are presented in three datasets: as a 1 mm depth resolution record, 3 cm averaged record, and decadally averaged record (based on the MBS2023 chronology). The 1 mm record represents an oversampling of the true resolution, as due to smoothing effects the actual resolution is closer to 3 cm for some species. Therefore, the 3 cm resolution dataset is considered to be the minimum true resolution given the system setup. We also describe the current Copenhagen CFA system, and provide a detailed assessment of data quality, precision, and functional resolution.<br/><br/>A full description of the dataset is provided in Harlan et al., 2024 (in prep).<br/><br/>Acknowledgements: We would like to acknowledge significant contributions from Paul Vallelonga. The authors would like to thank all participants in the 2018 and 2019 CFA campaigns, including, but not limited to Marius Simonsen, Alexander Zhuravlev, Mirjam Laderach, Nicholas Robles, Estelle Ngoumtsa, Michelle Shu-Ting Lee, Janani Venkatesh, Danielle Udy, Zurine Yoldi, Jia-mei Lin, Anna-Marie Klüssendorf, Andrew Moy, Andy Menking, Todd Sowers, Christo Buziert, Jesper Liisberg, and David Soestmeyer. The Mount Brown South ice core project is led by Tessa Vance, and would not be possible without the team of scientists, technicians, and ice core drillers, including Paul Vallelonga, Jason Roberts, Nerilie Abram, Meredith Nation, Chelsea Long and Alison Criscitiello
Past, present, and future of mars polar science: Outcomes and outlook from the 7th international conference on mars polar science and exploration
No full textMars Polar Science is a subfield of Mars science that encompasses all studies of the cryosphere of Mars and its interaction with the Martian environment. Every 4 yr, the community of scientists dedicated to this subfield meets to discuss new findings and debate open issues in the International Conference on Mars Polar Science and Exploration (ICMPSE). This paper summarizes the proceedings of the seventh ICMPSE and the progress made since the sixth edition. We highlight the most important advances and present the most salient open questions in the field today, as discussed and agreed upon by the participants of the conference. We also feature agreed-upon suggestions for future methods, measurements, instruments, and missions that would be essential to answering the main open questions presented. This work is thus an overview of the current status of Mars Polar Science and is intended to serve as a road map for the direction of the field during the next 4 yr and beyond, helping to shape its contribution within the larger context of planetary science and exploration. © 2021. The Author(s).Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Valorization of agro-food by-products and their potential therapeutic applications
No full textAgro-food industries generate a huge amount of fruit and vegetable wastes. These residues are composed by structural parts (leaves, peels, pulps, seeds, roots and stems) after the extraction of their juices, and they are rich in bioactive compounds such polyphenols, protein, carbohydates, fibre, lignin, lipids and minerals. Therefore, these wastes constitute a source of bioactive compunds and their valorization leads to a circular economy in which industry and society benefit. Between the component of the residues, polyphenols compounds may contribute to prevent or treated cancer, neurodegenerative and cardiovascular diseases, among others. The aim of this work was the study of the potential therapeutic effect of fruit and vegetable extracts (peach, apple, cucumber and red pepper) obtained by ultrasounds, on different lines of cancer cells (colon, liver and breast) and on oxidative stress in a healthy colon. The results showed that extracts rich in polyphenols had an antiproliferativeeffect against tumor cells and their action was improved by encapsulation in maltodextrin. Encapsulation also increased the protection against oxidative stress in intestinal cells. This study opened the gate to use the extracts from fruit and vegetable wastes as pharmaceutical excipients, food additives, nutraceutical products or functional foods for therapeutic purposes and prevention of diseases related to oxidative stress.SOE1/P1/E0123 Interreg Sudoe REDVALUE, Technological Alliance to Complete the Forest and Agroindustrial Production Cycle. Authors also thank the Ministry of Economy and Innovation under Grant (SAF2016-75441-R); Aragón Regional Government (B16-20R, Fondos FEDER "Otra manera de hacer Europa") and CIBERobn under Grant (CB06/ 03/1012) of the Instituto de Salud Carlos III. Author Raquel Ibarz thanks the University of Lleida for the UdL-Impuls post-doctoral contract. In addition, this study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. Pedro Santos is recipient of a fellowship supported by a doctoral advanced training (call NORTE-69-2015-15) funded by the European Social Fund under the scope of Norte2020 - Programa Operacional Regional do Norteinfo:eu-repo/semantics/publishedVersio
A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism
No full textPulmonary embolism (PE) can result in long-term sequelae, such as post-PE syndrome, including persistent dyspnea and chronic thromboembolic pulmonary hypertension (CTEPH). Existing prediction tools for severe post-PE complications lack sensitivity and specificity. This study aimed to develop a machine learning model to identify patients at risk for long-term consequences after PE. Using data from the RIETE registry, the largest prospective international PE registry, we developed supervised machine learning models to identify patients at increased risk of CTEPH and post-PE syndrome. Our approach involved data preprocessing, model training via random forest algorithm, and validation through Monte-Carlo cross-validation. The performance of the CTEPH prediction model was benchmarked against an existing score. Of the 57,981 PE patients in the RIETE registry, 5,217 were eligible for inclusion. Median age was 68 years, with 50.6% men. Machine learning was based on 111 predictor variables, with 171 patients (3.3%) developing CTEPH. The CTEPH model demonstrated good performance with an AUC of 0.74 (95%CI: 0.73-0.75), significantly outperforming the existing CTEPH prediction score (0.57; 0.54-0.61). Additionally, 1,310 (25.1%) patients were defined as having post-PE syndrome six months after index PE. The post-PE syndrome model showed poorer performance with an AUC of 0.62 (0.61-0.62). Key predictor variables across both models included chest pain at presentation, PE location, troponin, side of clot, and dyspnea at presentation. Machine learning models show promise in predicting CTEPH but are less effective for post-PE syndrome. Future refinement, including integrating imaging data, is necessary to improve predictive performance and clinical utility.
© 2025. The Author(s)
Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
No full textBackground: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. Methods: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. Results: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. Conclusion: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition. © 2023, The Author(s)
Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder
No full textBackground: The rate of suicide attempts by patients with bipolar disorder is high. In addition to patient and country specific factors, environmental factors may contribute to suicidal behavior. Sunlight has multiple diverse impacts on human physiology and behavior. Solar insolation is defined as the electromagnetic energy from the sun striking a surface area on earth. We previously found that a large change in solar insolation between the minimum and maximum monthly values was associated with an increased risk of suicide attempts in patients with bipolar I disorder. Methods: The association between solar insolation and a history of suicide attempts in bipolar disorder was again investigated using an international database with 15% more data and more sites at diverse locations and countries. Results: Data were available from 5641 patients with bipolar I disorder living at a wide range of latitudes in 41 countries in both hemispheres. A large change in solar insolation between the minimum and maximum monthly values was associated with a history of suicide attempts in patients with bipolar I disorder, a replication of our prior analysis. The estimated model also associated state sponsored religion in the onset country, female gender, a history of alcohol or substance abuse, and being part of a younger birth cohort with a history of suicide attempts. Conclusions: A large change between the minimum and maximum monthly values of solar insolation was associated with a history of suicide attempts in bipolar I disorder, replicating our prior research. Physicians should be aware that daylight has wide ranging physiological and psychiatric impacts, and that living with large changes in solar insolation may be associated with an increased suicide risk. © The Author(s) 2024
