253 research outputs found
Photodissociation of molecular ions and low-energy collisions of atoms and ions
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1993.Includes bibliographical references.by Atul D. Pradhan.Ph.D
Conditional models for 3D human pose estimation:
No full textHuman 3d pose estimation from monocular sequence is a challenging problem, owing to highly articulated structure of human body, varied anthropometry, self occlusion, depth ambiguities and large variability in the appearance and background in which humans may appear. Conventional vision based approaches to human 3d pose estimation mostly employed "top-down methods", which used a complete 3d human model, in a hypothesized pose, to explain the configuration of the humans in the observed 2d image. In this thesis, we work with "bottom-up methods" for human pose estimation, that use low level image features to directly predict 3d pose. The research draws on recent innovations in statistical learning, observation-driven modeling, stable image encodings, semi-supervised learning and learning perceptual representations. We address the problems of (a) modeling pose ambiguities due to 3d-to-2d projection and self occlusion, (b) lack of sufficient labeled data for training discriminative models and (c) high dimensionality of human 3d pose state space. In order to resolve 3d pose ambiguities, we use multi-valued functions to predict multiple plausible 3d poses for an image observation. We incorporate unlabeled data in a semi-supervised learning framework to constrain and improve the training of discriminative models. We also propose generic probabilistic Spectral Latent Variable Models to efficiently learn low dimensional representations of high dimensional observation data and apply it to the problem of human 3d pose inference.Ph.D.Includes bibliographical references (p. 182-193)by Atul Kanauji
Mutual information relevance networks : functional genomic networks built from pair-wise entropy measurements
No full textThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Thesis (S.M.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 2002.Includes bibliographical references (leaves 27-28).by Atul Janardhan Butte.Thesis (S.M.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 2002
The Influence of Glycerol and Specific Genes on the Asymmetric Cell Division in Mycobacteria
No full textThe Influence of Glycerol and Specific Genes
on the Asymmetric Cell Division in Mycobacteria
Submitted by Atul Pradhan (S.R. No. 03-04-00-10-11-14-1-11678)
Background Information: Mycobacteria maintain heterogeneity in cell-length, morphology, and metabolic differences in in vitro cultures, infected mice and guinea pigs, and tuberculosis patients. We had reported that ~20-30% of the septating mid-log phase cells of Mycobacterium smegmatis, Mycobacterium tuberculosis, and Mycobacterium xenopi undergo highly deviated asymmetric constriction during division (ACD) to generate short-sized cells (SCs) and normal/long-sized cells (NCs) as sister-daughter cells having differential susceptibility to oxidative/nitrite/antibiotic stress. The remaining 70-80% of the septating cells undergo more-or-less symmetric constriction during division (SCD) generating sister-daughter cells of more-or-less comparable length, as shown by us and other groups. We found that cell-length heterogeneity was achieved in mycobacteria by generating differently sized sister-daughter cells through ACD of NCs and SCD of SCs and NCs, as one of the mechanisms. Subsequently, we discovered Ap6A as the molecule, which gets secreted into the growth medium, that induces ACD in M. smegmatis and M. tuberculosis in a paracrine/autocrine manner and the levels of which in change with growth phase. Ap4A, which was introduced into the medium, was also found to induce ACD.
In Escherichia coli and Bacillus subtilis, cell-size heterogeneity is affected by the availability of glucose in the culture medium for which UDP-glucose (UDPG) serves as the intracellular proxy for nutrient availability and its concentration decides the cell size during the division. In the present study on M. smegmatis, despite the absence of the orthologues of UgtP of B. subtilis and OpgH of E. coli that are involved in UDPG metabolism, we examined the influence of glycerol on the proportions of cells undergoing division by ACD and SCD. Further, we identified the genes that influence the synthesis and degradation of Ap4A, which is another ApnA, probably the precursor to Ap6A, also found to be involved in inducing ACD.
Layout of the Thesis: The Chapter 1, which forms the Introduction to the thesis, gives an extensive literature survey on different areas of research in the bacterial physiology that are linked to the present study. These areas of research include bacterial cell division, different mode of cell division in mycobacteria, cell division related proteins in bacteria, relation between cell division and nutrient status, different carbon sources used by bacteria for survival, estimation of free glycerol in the medium, genes and its biochemical activity, related to diadenosine polyphosphates synthesis and phosphorylation in bacteria.
The Chapter 2 forms the Material and Methods used in the present study. Here a detailed description of the methods used to study growth phase of bacteria, cell division and bioassay used to score for the proportion of cells undergoing symmetric and asymmetric constriction during division, assay for free glycerol concentration in the medium, Ap6A exposure to M. smegmatis (Msm) and its effect on ACD/SCD, RNA extraction and qPCR analysis, Protein overexpression of MSMEG_2932 and its biochemical activity using different substrate followed by identification and quantitation of different products with the help of HPLC.
The Chapter 3 forms the first data chapter that presents the results on the effects of growth phase of Msm and free glycerol concentration in the medium on the proportions of cells dividing by SCD and ACD. Here we have shown as to how the changes in the glycerol (main carbon source) concentration with the growth phase affect the proportion of cells dividing by SCD and ACD in the population. The population shows change in the proportion of SCD and ACD. The proportion could be maintained by maintaining free glycerol concentration in the medium. We had also tested the effect of spent medium from different growth phases on the ACD:SCD proportions.
The Chapter 4 forms the data chapter that presents the levels of expression of MSMEG_2932, MSMEG_2933, and MSMEG_2936, which were found to influence ACD. Hence the proportions of cells dividing by ACD:SCD, in a growth phase dependent manner, were determined using the respective gene knockout mutants. The ACD:SCD proportion change with growth phase and glycerol concentration in the medium was more or less reversed or unaffected in the KO strains. Quantitative PCR was performed for the expression levels of the three genes at 0.8 OD and in the Ap6A-exposed cells.
This data chapter also presents the results of MSMEG_2932 protein overexpression, purification and study of activity as an Ap4A hydrolase/phosphorylase and as Ap4A synthase at a variety of conditions involving different pH, buffers, temperatures, and divalent ions. Thus, the present study for the first time has shown the influence of glycerol on ACD:SCD proportions in the dividing population of Msm cells. The present study also reports the in vitro synthesis of Ap4A by MSMEG_2932, using ATP as the substrate.
The thesis is concluded with a section on general discussion, salient findings from the work, followed by an extensive bibliography
Business and Politics in India
No full textOverview Description Table of Contents Author InformationCoverBusiness and Politics in IndiaEdited by Christophe Jaffrelot, Edited by Atul Kohli, and Edited by Kanta MuraliModern South AsiaDescriptionOver the last few decades, politics in India has moved steadily in a pro-business direction. This shift has important implications for both government and citizens. In Business and Politics in India, leading scholars of Indian politics have gathered to offer an analytical synthesis of this vast topic. Collectively, they cover the many strategies that businesses have used to exert their newfound power in recent times and organize the book around a few central concerns. They first analyze the nature of business power and how it shapes political change in India. Second, they look at the consequences of business' growing power on some important issue areas-labor, land, urban governance, and the media. Finally, they take account of regional variation and analyze state-business relations. This definitive account offers significant insights into how and why corporations have increased their power in contemporary Indian politics
Business and Politics in India
No full textOverview Description Table of Contents Author InformationCoverBusiness and Politics in IndiaEdited by Christophe Jaffrelot, Edited by Atul Kohli, and Edited by Kanta MuraliModern South AsiaDescriptionOver the last few decades, politics in India has moved steadily in a pro-business direction. This shift has important implications for both government and citizens. In Business and Politics in India, leading scholars of Indian politics have gathered to offer an analytical synthesis of this vast topic. Collectively, they cover the many strategies that businesses have used to exert their newfound power in recent times and organize the book around a few central concerns. They first analyze the nature of business power and how it shapes political change in India. Second, they look at the consequences of business' growing power on some important issue areas-labor, land, urban governance, and the media. Finally, they take account of regional variation and analyze state-business relations. This definitive account offers significant insights into how and why corporations have increased their power in contemporary Indian politics
Book Discussion of Being Mortal: Medicine and What Matters in the End by Atul Gawande
No full textIn Being Mortal, bestselling author Atul Gawande tackles the hardest challenge of his profession: how medicine can not only improve life but also the process of its ending. He asserts that medicine can comfort and enhance our experience even to the end, providing not only a good life but also a good end. — Barnes and Noble
Discussion Leader: Vida Lock. Served as Dean of Nursing, CSU
Friends of the Library book discussions are free and open to all CSU faculty, staff, and students and the general public. Refreshments will be served.
Contact Barbara Loomis at [email protected] for more information
Business and Politics in India
No full textOverview Description Table of Contents Author InformationCoverBusiness and Politics in IndiaEdited by Christophe Jaffrelot, Edited by Atul Kohli, and Edited by Kanta MuraliModern South AsiaDescriptionOver the last few decades, politics in India has moved steadily in a pro-business direction. This shift has important implications for both government and citizens. In Business and Politics in India, leading scholars of Indian politics have gathered to offer an analytical synthesis of this vast topic. Collectively, they cover the many strategies that businesses have used to exert their newfound power in recent times and organize the book around a few central concerns. They first analyze the nature of business power and how it shapes political change in India. Second, they look at the consequences of business' growing power on some important issue areas-labor, land, urban governance, and the media. Finally, they take account of regional variation and analyze state-business relations. This definitive account offers significant insights into how and why corporations have increased their power in contemporary Indian politics
Mahatma Gandhi and the depressed classes
No full textBiennial Professor H.K. Barpujari endowment lectures(2005-06) delivered by the author at Kolkata during 21-22 February 2006
Analyzing Advancement in Crowdfunding Research and Envisioning its Future: A Bibliometric Approach
No full textPublished online 24 July 2023. Published in print 1 August 2023.Academy of Management Annual Meeting Proceedings includes abstracts of all papers and symposia presented at the annual conference, plus 6-page abridged versions of the “Best Papers” accepted for inclusion in the program (approximately 10%). Papers published in the Proceedings are abridged because presenting papers at their full length could preclude subsequent journal publication. Please contact the author(s) directly for the full papers.Crowdfunding represents an emerging alternative means of marshaling resources which may prove to be a game-changer in the entrepreneurial finance landscape. Although the rapid growth in this field has yielded a multidisciplinary body of work, the scaffolding of this vast body of work is still largely unknown in the scholarly domain. We conduct a bibliometric analysis of 534 crowdfunding articles to uncover the intellectual landscape of crowdfunding research. Our comprehensive co-citation analysis reveals two generations of crowdfunding research, identifies the most researched themes in area, and highlights its theoretical and disciplinary anchors. In addition, our bibliographic cartography traces the shifts in areas of interest of scholars within the heterogeneous field. Overall, our critical analysis of the most influential conversations in crowdfunding research helps reveals gaps in the extant literature which act as fertile directions for its future inquiry
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