61 research outputs found
Physicochemical screening and shelf life evaluation of Kuṅkumādi Ghṛta prepared using Kesara and Nāgakesara
No full textIntroduction: Kuṅkumādi Ghṛta (KG) is an Ayurvedic formulation commonly recommended in skin disorders, especially Mukhadūṣikā (Acne vulgaris). Kesara (stigma of Crocus sativus Linn.) is a prime ingredient in the formulation. However, due to high cost and increased adulteration in Kesara, 'Nāgakesara' (Mesua ferrea Linn.) is suggested by Ayurvedic experts as a substitute. Nāgakesara is relatively lower in cost and possesses similar therapeutic attributes to that of Kesara. Recent studies have established standard manufacturing procedures and clinical efficacies of Kesarayukta (with Kesara) Kuṅkumādi Ghṛta (KKG) and Nāgakesara yukta (with Nāgakesara) Kuṅkumādi Ghṛta (NKG) in Mukhadūṣikā. In spite of wide utility of KG in Ayurvedic practice, no published work on its shelf life is available so far. Aims and Objectives: To establish the physicochemical profile and evaluate the shelf life of KKG and NKG. Materials and Methods: Total three batches of KKG and NKG each were prepared in the laboratory by adopting Ayurvedic classical guidelines and the findings were systematically recorded. Comparative differences in organoleptic characters (colour, odour, taste, touch) and values of different physicochemical parameters (Ash value, pH value, Total solid content, Specific gravity, Refractive index, Loss on drying, Acid value, Iodine value, Saponification value, Peroxide value and Rancidity tests) of raw materials [herbal ingredients, Go Ghṛta, Mūrcchita Ghṛta (MG)] as well as finished products (KKG and NKG) were recorded. Long term (real time) shelf life testing was carried out at the intervals i.e., at 0, 3, 6, 9 and 16 months. High performance thin layer chromatography (HPTLC) analysis of samples was also carried out. Results and Conclusion: The average percentage loss in final product was 10.18% in KKG and 7.58% in NKG. The shelf life of MG, KKG and NKG is 16 months. After 16 months, Go Ghṛta showed negative rancidity test, while MG, KKG and NKG showed positive rancidity, indicative of onset of deterioration after 16 months. Present findings validate the Ayurvedic principles stipulating medicated Ghṛta to have a shelf life of 16 months. Chromatographic study showed few differences between KKG and NKG samples. Data obtained by present study may be considered as standard for future researches
Enhanced Oil Recovery using Carbonated Polymeric Nanofluids : A New Age Approach to CO2 Utilization and Corrosion Mitigation
No full textThe author would like to thank the CIF facility and its staff, including Mr. Anuj Prajapati, Mr. Zahoor Alam, and Mr. Brijesh. Thanks are also extended to all the members associated with the work.Peer reviewe
Knowledge and awareness of diabetes among diabetic patients in hilly terrains of Mandi district, Himachal Pradesh
No full textPhysicochemical characterization of Shadguna Balijarita Makaradhwaja: A preliminary study
No full textEthno medicinal values of Citrus genus: A review
No full textFruits of Citrus genus play an important role as a dietary supplement and therapeutic assent as well since ages. The present review summarizes some such attributes of Citrus genus. Literature review was done through published works to gather information on nutritional and ethnic values, phytochemical and pharmacological properties of Citrus. Information about the plant and phytochemical constituents, pharmacological activities were collected from the published reports. The plant was found to possess significant analgesic, anti-inflammatory, antioxidant, anthelmintic, antibacterial, antifungal, and hypolipidemic properties. They are found to be significant antihyperglycemic, antidiabetic, and hypoglycemic activity. The phytoconstituents which are present in the plant are mainly coumarins and flavonoids which are responsible for the actions. The phytochemical constituents and isolated bioactive compounds of Citrus can be investigated further to develop novel herbal drugs by using reverse pharmacological approaches especially in the treatment of liver diseases, arthritis, malignancies, and other inflammatory diseases
Developing E. coli-E. coli co-cultures to overcome barriers of heterologous tryptamine biosynthesis
No full textTryptamine is an alkaloid compound with demonstrated bioactivities and is also a precursor molecule to many important hormones and neurotransmitters. The high efficiency biosynthesis of tryptamine from inexpensive and renewable carbon substrates is of great research and application significance. In the present study, a tryptamine biosynthesis pathway was established in a metabolically engineered E. coli-E. coli co-culture. The upstream and downstream strains of the co-culture were dedicated to tryptophan provision and conversion totryptamine, respectively. The constructed co-culture was cultivated using either glucose or glycerol as carbon source for de novo production of tryptamine.The manipulation of the co-culture strains’ inoculation ratio was adapted to balance the biosynthetic strengths of the pathway modules for bioproduction optimization. Moreover, a biosensor-assisted cell selection strategy was adapted to improve the pathway intermediate tryptophan provision by the upstream strain, which further enhanced the tryptamine biosynthesis. The resulting biosensor-assisted modular co-culture produced 194mg/L tryptamine with a yield of 0.02 g/g glucose using shake flask cultivation.The findings of this work demonstrate that the biosensor-assisted modular co-culture engineering offers a new perspective for conducting microbial biosynthesis.Peer reviewe
Design and Governance of Platforms to leverage an ecosystem of complementors
No full textThis paper analyzes how specific aspects of design and governance of platform explain complementors participation in the video game console industry. This study introduces a new dimension to measure platform openness and suggest that by opening the platform vertically to different markets, platform firms can smoothen complementors competition and incentivize them to participate in their network. This study makes a first attempt to measure platform boundary resources and highlight its positive influence on complementors participation. Finally, the analysis also explores conditions under which signing an exclusive contract is beneficial for complementors. Complementors tend to participate in exclusive contracts during the early stages of platform rather than mature stages due to intense competition among complementors in the latter stage. The results suggest that by following the correct design and governance strategies, platform firms can orchestrate a large network of complementors and proliferate a variety of complementary product offerings
Role of Gandhaka Jarana in the Mercurial preparations of Indian Medicinal Alchemy (Rasashastra)
No full textEvaluation of Gandhakadi Yoga as an adjuvant therapy in the management of Beejadushtijanya Pandu (thalassemia major)
No full textSTANDARD MANUFACTURING PROCEDURE OF SHADGUNA BALIJARITA MAKARADHWAJA BY ADOPTING TRADITIONAL METHOD - A PRELIMINARY STUDY
No full textIntroduction: Gandhaka Jarana is intermediate procedure for the therapeutic mercurial preparations in Ayurveda Rasashastra. For Gandhaka Jarana numerous procedures were mentioned in the classical texts of Rasashastra. Here, Shadguna Balijarita Makaradhwaja prepared in classical Valuka Yantra by adopting one of the method of Gandhaka Jarana.
Objective: To prepare Shadguna Balijarita Makaradhwaja by traditional method of preparation by Valuka Yantra and to standardize its heating pattern.
Materials and Methods: Shodhana of each ingredient was done followed by Kajjali preparation. Levigated and dried Kajjali was filled in KachpKupi and intermittent increasing heat was given in Valuka Yantra. Sublimed Shadguna Balijarita Makaradhwaja was obtained from neck of glass of glass bottle.
Observation and results: For 16 hours heat was provided in Valuka Yantra. Average 12.77% i.e. 32.33 g yield of Makaradhwaja was obtained from all three batches of Shadguna Balijarita Makaradhwaja.
Conclusion: Shadguna Gandhaka Jarana for Makaradhwaja prepared in the classical heating device Valuka Yantra by adopting addition of parts of Shuddha Gandhaka during ongoing process method; requires intermittent heat heating pattern i.e. 4.30 hours mild heat (30- 5000C), 1:30 hours moderate heat (500-6500C), and 10 hours strong heat (650-8400C)
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