542 research outputs found
Gas Discharge Visualization (Electrophotonic Imaging, Kirlianography). Theoretical and Applied Aspects
No full textBabelyuk Valeriy Y., Popovych Igor L., Gozhenko Anatoliy I., Dubkova Galyna I., Kozyavkina Olga V., Korolyshyn Tetyana A., Babelyuk Nazariy V., Kovbasnyuk Marta M., Fihura Oksana A., Dobrovolskyi Yuriy G., Zukow Walery, Yanchij Roman I. Gas Discharge Visualization (Electrophotonic Imaging, Kirlianography). Theoretical and Applied Aspects. Odesa. Feniks; 2023: 200. ISBN 978-1-4478-8957-1. DOI http://dx.doi.org/10.5281/zenodo.7535880
The monograph highlights the results of priority clinical-physiological studies of the relationships between gas discharge visualization (electrophotonic imaging, kirlianography) parameters, on the one hand, and electroencephalograms, heart rate variability, immunograms, phagocytosis, the content of the main adaptation hormones (cortisol, aldosterone, testosterone, triiodothyronine, calcitonin) in the blood as well as acupuncture points - on the other hand. It is shown that the GDV/EPI method reliably reflects the state of the body's neuro-endocrine-immune complex as well as others parameters and has the right to take its place in the arsenal of physiological/biophysical methods.
For biophysicists, physiologists, psychophysiologists, endocrinologists, immunologists, medical rehabilitation specialists.
Bohomolets’ Institute of Physiology
National Academy of Sciences, Kyїv, Ukraine
Ukrainian Scientific Research Institute of Medicine of Transport
Ministry of Health of Ukraine, Odesa
Kozyavkin International Rehabilitation Clinic, Truskavets’, Ukraine
Yuriy Fed’kovych National University
Ministry of Science and Education, Chernivtsi, Ukraine
Editors
Valeriy Y. Babelyuk
Igor L. Popovych
GAS DISCHARGE VISUALIZATION
(ELECTROPHOTONIC IMAGING, KIRLIANOGRAPHY).
THEORETICAL AND APPLIED ASPECTS
ODESA
FENIKS
2023
Authors
Valeriy Y. Babelyuk, MD, PhD; Clinical sanatorium “Moldova”, Truskavets’; UkrSR Institute of Medicine of Transport [email protected]
Igor L. Popovych, MD, PhD, senior res. fel.; Bohomolets’ Institute of Physiology; Kozyavkin International Rehabilitation Clinic; UkrSR Institute of Medicine of Transport [email protected]
Anatoliy I. Gozhenko, MD, DS, Prof.; UkrSR Institute of Medicine of Transport [email protected]
Galyna I. Dubkova, MD, PhD; Clinical sanatorium “Moldova”, Truskavets’ [email protected]
Olga V. Kozyavkina, MD, PhD; Kozyavkin International Rehabilitation Clinic [email protected]
Tetyana A. Korolyshyn, MD; UkrSR Institute of Medicine of Transport; Bohomolets’ Institute of Physiology [email protected]
Nazariy V. Babelyuk, MD; Clinical sanatorium “Moldova”, Truskavets’
Marta M. Kovbasnyuk, PhD, senior res. fel.; Bohomolets’ Institute of Physiology [email protected]
Oksana A. Fihura, MD; UkrSR Institute of Medicine of Transport; Ivan Franko State Pedagogical University, Drohobych, Ukraine [email protected]
Yuriy G. Dobrovolskyi, DS, Prof. ass.; Yuriy Fed’kovych National University [email protected]
Walery Zukow, MD, DS, Prof. ass.; Nicolaus Copernicus University, Torun, Poland [email protected]
Roman I. Yanchij, DS, Prof.; Bohomolets’ Institute of Physiology [email protected]
We dedicate the monograph to the 115th anniversary of the birth
of the Luminary of Neurophysiology
Academician Philip Nikolayevich Serkov (1908-2011)
with gratitude for the support of the Truskavetsian Scientific School
Recommended for publication by the Academic Council
of Bohomolets’ Institute of Physiology National Academy of Sciences of Ukraine
(protocol No. 13 dated 12/22/2022)
Reviewers:
Regeda Mykhaylo S., MD, DS, Prof, head of the department of pathophysiology of the Danylo Halyts’kyi National Medical University, L’viv, Ukraine
Vastyanov Ruslan S., MD, DS, Prof, head of the department of general and clinical pathophysiology named after VV Podvysotskyi of the National Medical University, Odesa, Ukraine
Babelyuk VY & Popovych IL [editors]. Gas Discharge Visualization (Electrophotonic Imaging, Kirlianography). Theoretical and Applied Aspects: monograph / Babelyuk VY, Popovych IL, Gozhenko AI, Dubkova GI, Kozyavkina OV, Korolyshyn TA, Babelyuk NV, Kovbasnyuk MM, Fihura OA, Dobrovolskyi YG, Zukow W, Yanchij RI. Odesa. Feniks; 2023: 186.
Babelyuk Valeriy Y., Popovych Igor L., Gozhenko Anatoliy I., Dubkova Galyna I., Kozyavkina Olga V., Korolyshyn Tetyana A., Babelyuk Nazariy V., Kovbasnyuk Marta M., Fihura Oksana A., Dobrovolskyi Yuriy G., Zukow Walery, Yanchij Roman I. Gas Discharge Visualization (Electrophotonic Imaging, Kirlianography). Theoretical and Applied Aspects. Odesa. Feniks; 2023: 200. ISBN 978-1-4478-8957-1. DOI http://dx.doi.org/10.5281/zenodo.7535880
The monograph highlights the results of priority clinical-physiological studies of the relationships between gas discharge visualization (electrophotonic imaging, kirlianography) parameters, on the one hand, and electroencephalograms, heart rate variability, immunograms, phagocytosis, the content of the main adaptation hormones (cortisol, aldosterone, testosterone, triiodothyronine, calcitonin) in the blood as well as acupuncture points - on the other hand. It is shown that the GDV/EPI method reliably reflects the state of the body's neuro-endocrine-immune complex as well as others parameters and has the right to take its place in the arsenal of physiological/biophysical methods.
For biophysicists, physiologists, psychophysiologists, endocrinologists, immunologists, medical rehabilitation specialists.
ISBN 978-1-4478-8957-1
DOI http://dx.doi.org/10.5281/zenodo.7535880
© Bohomolets’ Institute of Physiology, Kyїv, 2023
© Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, 2023
© Kozyavkin International Rehabilitation Clinic, Truskavets’, 2023
© Yuriy Fed’kovych National University, Chernivtsi, 2023
© Authors
ISBN 978-1-4478-8957-1
DOI http://dx.doi.org/10.5281/zenodo.7535880
INTRODUCTION (Babelyuk VY, Popovych IL) 6
CHAPTER 1 (Babelyuk VY, Popovych IL, Gozhenko AI, Yanchij RI)
REVIEWS
Biofield science and healing 8
Biofield devices 15
Application of electrophoton capture (EPC) analysis based on gas discharge visualization (GDV) technique in medicine 18
OWN RESULTS. THEORETICAL ASPECTS
CHAPTER 2 (Babelyuk VY, Popovych IL, Dubkova GI)
PILOT STUDIES 27
CHAPTER 3 (Babelyuk VY, Popovych IL, Dubkova GI, Gozhenko AI, Korolyshyn TA)
CAUSAL RELATIONSHIPS BETWEEN THE PARAMETERS OF GAS DISCHARGE VISUALIZATION AND PRINCIPAL NEUROENDOCRINE FACTORS OF ADAPTATION 45
CHAPTER 4 (Babelyuk VY, Popovych IL, Gozhenko AI, Dubkova GI, Zukow W)
CAUSAL RELATIONSHIPS BETWEEN THE PARAMETERS OF GAS DISCHARGE VISUALIZATION AND IMMUNITY 62
CHAPTER 5 (Babelyuk VY, Popovych IL, Gozhenko AI, Dubkova GI, Kovbasnyuk MM, Zukow W)
CAUSAL RELATIONSHIPS BETWEEN THE PARAMETERS OF GAS DISCHARGE VISUALIZATION AND PHAGOCYTOSIS AS WELL AS LEUKOCYTOGRAM 75
CHAPTER 6 (Babelyuk VY, Popovych IL, Gozhenko AI, Dubkova GI, Korolyshyn TA, Zukow W)
PARAMETERS OF GAS DISCHARGE VISUALIZATION CORRELATED WITH PARAMETERS OF ACUPUNCTURE POINTS, EEG, HRV AND HORMONES
OWN RESULTS. APPLIED ASPECTS 87
CHAPTER 7 (Babelyuk VY, Popovych IL, Dobrovolskyi YG, Gozhenko AI, Dubkova GI, Korolyshyn TA, Babelyuk NV, Zukow W)
REACTIONS OF GDV PARAMETERS TO TRANSCUTANEOUS ELECTRICAL STIMULATION BY DEVICES “VEB-1” AND “VEB-2” 112
CHAPTER 8 (Babelyuk VY, Popovych IL, Fihura OA, Gozhenko AI, Dubkova GI, Korolyshyn TA, Zukow W)
REACTIONS OF GDV PARAMETERS TO TAKING OF NAFTUSSYA BIOACTIVE WATER AND PHYTOADAPTOGEN 130
CHAPTER 9 (Babelyuk VY, Popovych IL, Kozyavkina OV, Dubkova GI, Korolyshyn TA, Zukow W)
REACTIONS OF GDV PARAMETERS OF CHILDREN WITH CEREBRAL PALSY TO TREATMENT BY KOZYAVKIN© METHOD 142
CONCLUSION (Babelyuk VY, Popovych IL, Dobrovolskyi YG)
REFERENCES 169
INTRODUCTION
Advances in biophysics, biology, functional genomics, neuroscience, psychology, psychoneuroimmunology, and other fields suggest the existence of a subtle system of “biofield” interactions that organize biological processes from the subatomic, atomic, molecular, cellular, and organismic to the interpersonal and cosmic levels. Biofield interactions may bring about regulation of biochemical, cellular, and neurological processes through means related to electromagnetism, quantum fields, and perhaps other means of modulating biological activity and information flow. The biofield paradigm, in contrast to a reductionist, chemistry-centered viewpoint, emphasizes the informational content of biological processes; biofield interactions are thought to operate in part via low-energy or “subtle” processes such as weak, nonthermal electromagnetic fields (EMFs) or processes potentially related to consciousness and nonlocality. Biofield interactions may also operate through or be reflected in more well-understood informational processes found in EEG and ECG data. Recent advances have led to the development of a wide variety of therapeutic and diagnostic biofield devices, defined as physical instruments best understood from the viewpoint of a biofield paradigm [Muehsam D et al, 2015].
Biofield devices comprise physical instruments that may be most clearly understood from the viewpoint of a biofield paradigm, and a large and diverse number of devices have been developed to measure or manipulate biofield interactions. These include both diagnostic devices (to measure biofield properties) and therapeutic devices (to manipulate biofield interactions). The study of biofield devices is at a nascent stage of development, and much further research is needed to determine clinical efficacy and elucidate the underlying mechanisms of action for many of the devices mentioned here. The biofield devices operate through a variety of modalities rather than a single mechanism. Some biofield devices function through well-understood mechanisms and are already widely used in clinical settings: for example, electroencephalography (EEG)- and electrocardiography (ECG)-based heart rate variability (HRV). Other devices appear to operate through mechanisms that are novel or incompletely understood. However, all of these devices share a common property: rather than functioning primarily in a reductionist, chemistry-centered manner, biofield devices function via the informational content of biological processes and can interact via low-energy or “subtle” processes, including those potentially related to consciousness and nonlocality [Muehsam D et al, 2015].
Here Muehsam D et al [2015] provide a brief overview of the broad categories of biofield devices, with the goal being to stimulate further discussion and research. Authors describe those devices for which thay deemed that sufficient evidence exists to warrant mention. They chose to focus upon devices for which peer-reviewed scientific reports suggesting efficacy are available rather than conference proceedings or manufacturers' white papers. However, in the few cases that specific devices with sufficient promise and relevance lacked a peer-reviewed basis, authors have presented whatever evidence was available. Here, devices are organized according to mode of operation and these modalities include electromagnetic field (EMF)-light, EMF-heat, EMF-nonthermal, electrical current, vibration and sound, physical and mechanical, intentionality and nonlocality, gas and plasma, and other (mode of operation not well understood).
Muehsam D et al [2015] deemed that gas discharge visualization (GDV) is an important example of the use of plasma in biofield science.
Back in 1880 Nikola Tesla demonstrated that when placing the man in the high-frequency field around the body there is a bright glow [cit. by Korotkov KG, 2001]. In 1892 Nardkevych-Yodko YO recorded glow human hands on photographic plate [cit. by Ciesielska I, 2009]. However, a well-known method of "high-frequency photography" was due to spouses Kirlian SD&VH who in 1939 independently discovered this phenomenon [Kirlian SD & Kirlian VKh, 1961], later called "Kirlian’s effect". This technique has been called corona discharge photography [Boyers DG & Tiller WA, 1973], electrophotography [Earle L, 1975], electrography [Konikiewicz LW, 1979], GDV [Bankovskii NG et al, 1986].
In 1996 Korotkov KG created a new scientific approach, based on the digital videotechnics, modern electronics and computer processing quantitative data, called as method gas discharge visualization (GDV bioelectrography). Parallel uses the terms Kirlianography and Electrophotonic imaging (EPI) [Korotkov KG, 2001; 2007; 2014; Korotkov KG et al, 2002; Wisneski LA & Anderson L, 2009; Jakovleva E & Korotkov K, 2013].
Method of GDV, essence of which consists in registration of photoelectronic emission of skin, induced by high-frequency electromagnetic impulses, allows to estimate integrated psycho-somatic state of organism. The first base parameter of GDV is Area of Gas Discharge Image (GDI) in Right, Frontal and Left projections registered both with and without polyethylene filter. The second base parameter is a coefficient of form/shape (ratio of square of length of external contour of GDI toward his area), which characterizes the measure of serration/fractality of external contour. The third base parameter of GDI is Entropy, id est measure of chaos. It is considered that GDI, taken off without filter, characterizes the functional changes of organism, and with a filter characterizes organic changes. Program estimates also Energy and Asymmetry of virtual Chakras [Korotkov KG, 2001; 2007; 2014].
Nearly 1000 papers have been published (mostly in Russian) on GDV research and a few hundred more in the West. These intriguing data suggest that informatics based upon biofield measurement devices such as the GDV may be useful for gaining deeper understanding of disease states and guiding practitioners and their patients towards states of greater wellness [Muehsam D et al, 2015].
Without regard to the wideuse enough of method in medicine, psychology, valeology and others like that, he yields to the just criticizing for an insufficient physiology ground. There fore we put before itself sweep to analyse relationships between the parameters of GDV - from one side, and by the row of neurodynamics, endocrine, immune. psychophysiological, and other parameters - on the other hand.
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Role of autonomous and endocrine factors in immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis
No full textKuchma, Igor L., Korda, Mykhaylo M., Klishch, Mykola I., Popovych, Dariya V., Żukow, Xawery, Popovych, Igor L. Role of autonomous and endocrine factors in immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis. Journal of Education, Health and Sport. 2022;12(5):362-385. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.05.029
https://apcz.umk.pl/JEHS/article/view/39817
https://zenodo.org/record/7052152
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.05.2022. Revised: 21.05.2022. Accepted: 31.05.2022.
ROLE OF AUTONOMOUS AND ENDOCRINE FACTORS IN IMMUNOTROPIC EFFECTS OF NITROGENOUS METABOLITES IN PATIENTS WITH CHRONIC PYELONEPHRITIS
Igor L. Kuchma1, Mykhaylo M. Korda2, Mykola I. Klishch2, Dariya V. Popovych2, Xawery Żukow3, Igor L. Popovych1,4
1Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine [email protected]
2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine [email protected] [email protected] [email protected]
3Medical University of Bialystok, Bialystok, Poland [email protected]
4Bohomolets’ OO Institute of Physiology of National Academy of Sciences, Kyїv, Ukraine [email protected]
Abstract
Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects in healthy rats and humans as well as patients with dysfunction of neuroendocrine-immune complex, encephalopatia and chronic pyelonephritis. The purpose of this study is clarification of the role of neuro-endocrine factors in their immunotropic activity in patients with chronic pyelonephritis. Materials and Methods. The object of observation were 17 men (aged 24-70 years) with chronic pyelonephritis in remission. The plasma levels and urinary excretion of nitrogenous metabolites as well as parameters of immunity and its neuro-endocrine regulation twice (on admission and after balneotherapy at the Truskavets’ Spa) was performed. Results. Judging by the multiple correlation coefficient, uricosuria exhibits maximal neuro-endocrine activity (R=0,780), followed by bilirubinemia (R=0,742), creatinineuria (R=0,692), uricemia (R=0,636), creatinineemia (R=0,632), urea excretion (R=0,536), instead urea plasma correlate with neuro-endocrine parameters insignificantly (R=0,360). Nitrogenous metabolites together determine the state of neuro-endocrine regulation by 94,2%, which, in turn, determine the state of immunity by 99,9%. Conclusion. Nitrogenous metabolites carry out immunomodulation in different ways: directly through aryl hydrocarbon (bilirubin), toll-like and adenosine (uric acid) receptors of immunocytes; through modulation of the activity of neurons of the autonomous nervous system and endocrinocytes with subsequent neuro-endocrine immunomodulation; and also, apparently, due to an off-receptor effect on neurons, endocrinocytes and immunocytes (urea and creatinine).
Keywords: bilirubin, uric acid, urea, creatinine, immunity, HRV, adaptation hormones, relationships, chronic pyelonephritis
Sexual dimorphism in some psycho-neuro-endocrine parameters at humana
No full textKOZYAVKINA, Nataliya, POPOVYCH, Igor, POPOVYCH, Dariya, ZUKOW, Walery & BOMBUSHKAR, Igor. Sexual dimorphism in some psycho-neuro-endocrine parameters at humana. Journal of Education, Health and Sport. 2021;11(5):370-391. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.039
https://apcz.umk.pl/JEHS/article/view/43195
https://zenodo.org/record/7749226
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.04.2021. Revised: 22.05.2021. Accepted: 30.05.2021.
Sexual dimorphism in some psycho-neuro-endocrine parameters at human
Nataliya V. Kozyavkina1, Igor L. Popovych1,2,5, Dariya V. Popovych3, Walery Zukow4, Igor S. Bombushkar5
1Kozyavkin International Rehabilitation Clinic, Truskavets’, Ukraine [email protected]
[email protected]
2Bohomolets’ Institute of Physiology of NAS of Ukraine, Kyїv, Ukraine
[email protected]
3IY Horbachevs’kyi Medical University, Ternopil’, Ukraine
[email protected]
4Nicolaus Copernicus University, Torun, Poland [email protected]
5Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine
[email protected]
Abstract
Background. Despite the well-documented relationships between HRV, EEG and anxiety parameters, studies of their sexual dimorphism, judging by the results of the meta-analysis, have so far been conducted separately. The purpose of this study is to clarify sexual dimorphism in almost synchronously registered psycho-neuro-endocrine parameters. Materials and Methods. The object of observation were practically healthy volunteers: 30 females (30÷76 yr) and 31 males (24÷69 yr). In basal conditions we recorded the ongoing HRV and EEG, determined serum levels of testosterone, calcitonin, cortisol, aldosterone, and triiodothyronine, estimated the severity of the trait and reactive anxiety. After 4 or 7 days, repeated testing was performed. Results. Regardless of age, females differ significantly from males, except for drastically lower levels of testosterone and calcitonin by definition (but not cortisol, aldosterone and triiodothyronine), lower levels of HRV-markers of sympathetic tone (but not heart rate), reactive anxiety, and beta-rhythm asymmetry. On the other hand, trait anxiety, levels of HRV-markers of vagal tone, variability and amplitude of the beta-rhythm, and its power spectral density (PSD) in 12 loci (maximum differences in T6, F3, and T3 loci), amplitude of the theta-rhythm and its PSD in 16 loci (maximum differences in F3, C3, and T3 loci), PSD of the alpha-rhythm in T3, T6, F7, and T4 loci as well as entropy of PSD in F7 and F8 loci are significantly higher in females than in males. The listed parameters are determined by testosterone for 31,7%, and calcitonin for 26,3%. The method of discriminant analysis revealed 20 EEG and 6 HRV parameters as well as trait and reactive anxiety, based on the totality of which males can be retrospectively recognized (without testosterone and calcitonin) with an accuracy of 90,3%, and females with an accuracy of 88,3%. Conclusion. The revealed differences between the sexes were not influenced by at least two bioactive factors, that is, they are robust sex markers.
Keywords: EEG, HRV, anxiety, testosterone, calcitonin, cortisol, aldosterone, triiodothyronine, males, females, sexual dimorphism
Relationships between changes in the state of neuroendocrine regulation and immunity in patients of Truskavets' spa
No full textPopovych Andriy I., Popovych Igor L., Popovych Dariya V., Ruzhylo Sofiya V., Żukow Xawery. Relationships between changes in the state of neuroendocrine regulation and immunity in patients of Truskavets’ spa. Journal of Education, Health and Sport. 2021;11(6): 335-347. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.06.036
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.06.036
https://zenodo.org/record/6561497
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 21.05.2021. Revised: 03.06.2021. Accepted: 30.06.2021.
Relationships between changes in the state of neuroendocrine regulation and immunity in patients of Truskavets’ spa
Andriy I. Popovych1,2, Igor L. Popovych1,2, Dariya V. Popovych3, Sofiya V. Ruzhylo4, Xawery Żukow5
1OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine [email protected]
2SE Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, Ukraine
3IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine [email protected]
4Ivan Franko Pedagogical University, Drohobych, Ukraine [email protected]
5Medical University of Bialystok, Bialystok, Poland [email protected]
Abstract
Background. Earlier we showed that the balneotherapeutic complex of Truskavets’ spa have significant modulating effects on parameters of EEG&HRV and Immunity of patients with chronic pyelonephritis and cholecystitis in remission accompanied of neuroendocrine-immune complex dysfunction. Were detected the close relationships between EEG, HRV, endocrine and immune parameters as well as between changes in EEG&HRV and immune parameters under the influence of balneotherapy. The aim of this study was to analyze the relationships between changes in the state of neuroendocrine regulation and immunity of the same patients. Materials and Methods. The object of clinical-physiological observation were 22 men aged 23-70 years, who underwent rehabilitation treatment of chronic pyelonephritis and cholecystitis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 9-11-day course of balneotherapy. The subject of the study were the parameters of the electroencephalogram, heart rate variability, hormones and immunity. Results. The method of canonical correlation analysis states that the changes in immunity caused by balneotherapy are determined by the constellation of alaptation hormones by 98,9%, the autonomic nervous system by 99,9%, the central nervous system by 99,7%. Conclusion. Immunomodulatory effect of balneotherapy is realized through the neuro-endocrine mechanism.
Keywords: Truskavets’ spa, EEG, HRV, hormonal and immune parameters, relationships
Features of neuro-endocrine and immune reactions to various water-salt loads in female rats
No full textGozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS. Journal of Education, Health and Sport. 2018;8(9):11-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1323491
http://ojs.ukw.edu.pl/index.php/johs/article/view/5729
https://pbn.nauka.gov.pl/sedno-webapp/works/872545
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017).
1223 Journal of Education, Health and Sport eissn 2391-8306 7
© The Author(s) 2018;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.06.2018. Revised: 28.06.2018. Accepted: 30.07.2018.
FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS
Olena A Gozhenko1, Yuriy V Zavidnyuk1,2, Mykhaylo M Korda2, Igor R Mysula2,
Ivan M Klishch2, Walery Zukow3, Igor L Popovych4
1Ukrainian Scientific Research Institute of Transport Medicine, Odesa, Ukraine, [email protected]
2IY Horbachevs’kyi State Medical University, Ternopil’, Ukraine, [email protected]
3Nicolaus Copernicus University, Torun, Poland, [email protected]
4OO Bohomolets’ Institute of Physiology, Kyiv, Ukraine, [email protected]
Abstract
Background. Previously, we have shown that the weekly load of rats with water-salt solutions of different chemical compositions causes both general and specific reactions of the parameters of metabolism. The purpose of this study is to identify under these conditions specific neuroendocrine and immune responses. Materials and methods. Experiment was performed on 58 healthy female Wistar rats 240-290 g divided into 6 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Instead, the other rats received the same tap water as well as waters Sophiya, Naftussya, Gertsa and its artificial salt analogue through the probe at a dose of 1,5 mL/100 g of body mass for 6 days. The day after the completion of the drinking course in all rats some neuroendocrine and immune parameters were registered. Results. The method of discriminant analysis revealed 29 parameters of the neuroendocrine-immune complex (10 of them reflect the neuroendocrine regulation, 4 thymus mass and thymocytogram elements, 5 elements of splenocytogram, 10 elements of immunocytogram and leukocytogram of blood and parameters of phagocytosis), according to which the reaction on various water-salt loads are identified with an accuracy of 98.3%. Conclusion. The peculiarities of the reactions of the parameters of the neuroendocrine-immune complex are due to the content of water in sulfate, bicarbonate and magnesium, as well as organic carbon and nitrogen.
Key words. Water-salt loads, neuroendocrine and immune parameters, female rats.Gozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS. Journal of Education, Health and Sport. 2018;8(9):11-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1323491
http://ojs.ukw.edu.pl/index.php/johs/article/view/5729
https://pbn.nauka.gov.pl/sedno-webapp/works/87254
Role of organic carbon and nitrogen of mineral waters in their immunomodulating effects at female rats
No full textPopovych Igor, Mysula Igor, Popovych Andriy, Mysula Yuriy, Sydliaruk Nataliya, Bilas Volodymyra, Zukow Walery. Role of organic carbon and nitrogen of mineral waters in their immunomodulating effects at female rats. Journal of Education, Health and Sport. 2021;11(9):886-894. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.104
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.104
https://zenodo.org/record/5856299
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.09.2021. Revised: 20.09.2021. Accepted: 30.09.2021.
ROLE OF ORGANIC CARBON AND NITROGEN OF MINERAL WATERS IN THEIR IMMUNOMODULATING EFFECTS AT FEMALE RATS
Igor Popovych1, Igor Mysula2, Andriy Popovych1, Yuriy Mysula2, Nataliya Sydliaruk2, Volodymyra Bilas1, Walery Zukow3*
1OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine
2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine
3Nicolaus Copernicus University, Torun, Poland
*[email protected]
Abstract
Background. Drinking mineral water is one of the ethnopharmacologic factors. Organic substances, despite their presence in all drinking mineral waters, are still considered to be active only in the water of Naftussya type (which, due to mineralization less than 1 g/L, are not formally mineral), whereas the physiological activity of true mineral waters (which mineralization is greater than 1-2 g/L) are associated with electrolytes and trace elements. Previously, we identified the role of organic carbon and nitrogen of mineral waters in their effects on certain metabolic and neuro-endocrine parameters. The purpose of this study is to clarify the role of organic substances of same mineral waters in their effects on immunity parameters. Material and methods. Experiment was performed on 48 healthy female Wistar rats 240-290 g divided into 5 groups. Animals of the first group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. In the second group we administered the water Naftussya from the Truskavets’ layer (Galychyna, Ukraine), in the third group the water Sophiya of the Truskavets’ field. The rats of the fourth group received the native water from the Hertsa (Bucovyna, Ukraine) field, and the last group received its artificial salt analogue. The day after the completion of the drinking course in all rats immunne parameters were registered. Results. On the basis of the correlation analysis with step-by-step exclusion, 9 immune parameters (Endotheliocytes of Thymus, Spleen Mass Index, Entropy of Splenocytogram, Natural Killers, B- and 0-Lymphocytes, Rod-shaped Neutrophils, Phagocytic Index and Microbian Count of Monocytes of Blood) are included in the regressive model for organic nitrogen (R=0,818) and 6 parameters (Endotheliocytes of Thymus, Fibroblastes and Reticulocytes of Spleen, Pan-Lymphocytes, Microbian Count of Neutrophils and Phagocytic Index of Monocytes of Blood) for organic carbon (R=0,690). Together, the organic components of the chemical composition of loading fluids determine their effect on the immune parameters by 77%. Conclusion. Organic substances of mineral waters play an essential role in their effects on the immune parameters of female rats.
Key words: Mineral waters, organic carbon and nitrogen, female rats, immunity
Canonical analysis of neuroendocrine-metabolic and neuroendocrine-immune relationships at female rats
No full textMel’nyk Oksana I., Zukow Walery, Hrytsak Myroslava V., Popovych Dariya V., Zavidnyuk Yuriy V., Bilas Volodymyra R., Popovych Igor L. Canonical analysis of neuroendocrine-metabolic and neuroendocrine-immune relationships at female rats. Journal of Education, Health and Sport. 2021;11(5): 356-369. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.038
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.05.038
https://zenodo.org/record/6099322
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.05.2021. Revised: 21.05.2021. Accepted: 28.05.2021.
CANONICAL ANALYSIS OF NEUROENDOCRINE-METABOLIC AND NEUROENDOCRINE-IMMUNE RELATIONSHIPS AT FEMALE RATS
Oksana I. Mel’nyk1, Walery Zukow2, Myroslava V. Hrytsak3, Dariya V. Popovych4, Yuriy V. Zavidnyuk3,4, Volodymyra R. Bilas5, Igor L. Popovych3,5
1Danylo Halyts’kyǐ National Medical University, L’viv, Ukraine [email protected]
2Nicolaus Copernicus University, Torun, Poland [email protected]
3Ukrainian Scientific Research Institute of Medicine for Transport, Odesa, Ukraine
[email protected]
4IY Horbachevs’kyi State Medical University, Ternopil’, Ukraine
[email protected]
5OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine [email protected]
Abstract
Background. It has been shown before that drinking mineral waters of different composition has a significant effect on the neuroendocrine, metabolic and immune parameters of healthy rats. We analyzed the canonical correlations between neuroendocrine parameters, on the one hand, and metabolic and immune parameters, on the other hand. Materials and Methods. Experiment was performed on 58 healthy female Wistar rats 240-290 g. HRV parameters, major adaptation hormones, metabolism and immunity parameters were recorded. Results. The method of canonical correlation analysis revealed causal relationships between neuroendocrine and metabolic and neuroendocrine and immune parameters of the organism. The degree of neuroendocrine determination of individual sets of metabolic parameters ranges from 60% to 92%, and immune status from 87% to 96,5%. Conclusion. Effects of mineral waters on metabolism and immunity are realized through nervous and hormonal mechanisms.
Keywords. HRV, hormones, metabolites, immunity, relationships, female rats
Sexual dimorphism in relationships between of uricemia and some psycho-neuro-endocrine parameters
No full textPopovych Igor L., Gozhenko Anatoliy I., Bombushkar Igor S., Korda Mykhaylo M., Zukow Walery. Sexual dimorphism in relationships between of uricemia and some psycho-neuro-endocrine parameters. Journal of Education, Health and Sport. 2015;5(5):556-581. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.6792499
https://apcz.umk.pl/JEHS/article/view/38976
Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.04.2015. Revised 15.05.2015. Accepted: 31.05.2015.
SEXUAL DIMORPHISM IN RELATIONSHIPS BETWEEN OF URICEMIA AND SOME PSYCHO-NEURO-ENDOCRINE PARAMETERS
Igor L. Popovych1,4, Anatoliy I. Gozhenko1, Igor S. Bombushkar1, Mykhaylo M. Korda2, Walery Zukow3
1Ukrainian Scientific Research Institute of Medicine of Transport, Odesa [email protected]; [email protected]
2IY Horbachevs’kyi Medical University, Ternopil’, Ukraine [email protected]
3Kazimierz Wielki University, Bydgoszcz, Poland [email protected]
4OO Bohomolets’ Institute of Physiology, Kyїv [email protected]
Abstract
Background. There is a hypothesis that urate is not only the end product of the metabolism of purines like adenosine, but even more a novel target for neuroprotection. The purpose of this study, conducted in line with this hypothesis, is to clarify the relationship between the level of uricemia and EEG/HRV parameters both in men and women. Materials and Methods. The object of observation were almost healthy volunteers: 30 females (30÷76; 49±13 y) and 31 males (24÷69; 47±12 y). In basal conditions we estimated the state of the autonomous regulation by the method HRV, recorded EEG, determined level of uric acid and testosterone as well as estimated level of the trait and reactive anxiety. After 4 or 7 days, repeated testing was performed. Results. The method of canonical correlation analysis revealed a strong urato-neural relationships in both men (R=0,709; R2=0,503; Adjusted R2=0,393) and women (R=0,812; R2=0,659; Adjusted R2=0,542). Moreover, in women, the factor structure of the neural root is almost completely different from that in men, and also includes reactive anxiety and HRV parameters, which are absent in the factor structure of men. In addition, significant differences were found between the profiles of urato-neural correlations of women of reproductive age and postmenopausal women. Conclusion. The level of uricemia is significantly related to a number of parameters of EEG, HRV and anxiety. The strength and even the direction of the correlations are determined by factors linked to gender.
Keywords: uricemia, EEG, HRV, anxiety, testosteroneemia, men, women
General non-specific effects of balneofactors of Truskavets' spa on parameters of neuroendocrine regulation, metabolism, immunity and microbiota in patients with chronic pyelonephritis and cholecystitis
No full textPopovych Igor L., Gozhenko Anatoliy I., Hrytsak Myroslava V., Popovych Dariya V., Korolyshyn Tetyana A., Kovbasnyuk Marta M., Zukow Walery. General non-specific effects of balneofactors of Truskavets’ spa on parameters of neuroendocrine regulation, metabolism, immunity and microbiota in patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2022;12(1):368-384. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.01.032
https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.01.032
https://zenodo.org/record/6375906
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.01.2022. Revised: 17.01.2022. Accepted: 31.01.2022.
General non-specific effects of balneofactors of Truskavets’ spa on parameters of neuroendocrine regulation, metabolism, immunity and microbiota in patients with chronic pyelonephritis and cholecystitis
Igor L. Popovych1,2, Anatoliy I. Gozhenko1, Myroslava V. Hrytsak1,2,
Dariya V. Popovych3, Tetyana A. Korolyshyn1,2, Marta M. Kovbasnyuk2,
Walery Zukow4
1SE Ukrainian Research Institute of Medicine of Transport, Odesa [email protected]
2Scientific group of Balneology of Hotel&Spa Complex "Karpaty", Truskavets’, Ukraine [email protected] [email protected]
3IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine [email protected]
4Nicolaus Copernicus University, Torun, Poland [email protected]
Abstract
Background. Earlier in experiments on rats, it was shown that drinking mineral water, regardless of their mineralization and chemical composition, have similar (nonspecific) course effects on a number of parameters of metabolism and neuroendocrine-immune complex. The aim of this study is to identify such parameters in patients of Truskavets’ spa who received complex drinking balneotherapy. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, therewith, 11 men additionally drank sulfate-chloride sodium-magnesium water "Khrystyna" (5 g/L), and the other 11 men - water "Myroslava" with a similar chemical composition, but twice the mineralization. The object of the study were the parameters of the electroencephalogram, heart rate variability (HRV), hormones, metabolism, immunity, microbiota and cholekinetics. Results. The complex balneotherapy by interval use of Naftussya water with sulfate-chloride sodium-magnesium mineral waters causes similar significant changes in the constellation of 10 EEGs, 10 metabolic, 10 microbiota and 4 immune parameters as well as total power and entropy of HRV, calcitonin and testosterone plasma levels and cholecystokinetics activity index. Conclusion. Balneofactors of Truskavets’ spa causes non-specific modulating effects on parameters of neuroendocrine regulation, metabolism, immunity, microbiota and cholekinetics in patients with chronic pyelonephritis and cholecystitis.
Keywords: drinking mineral waters, Truskavets’ spa, EEG, HRV, endocrine, immune, metabolic parameters, non-specific changes
Cluster analysis of hormonal constellation at women and men with harmonious and disharmonious general adaptation reactions
No full textHrytsak Yaroslav L, Barylyak Liliya G, Zukow Walery, Popovych Igor L. Cluster analysis of hormonal constellation at women and men with harmonious and disharmonious general adaptation reactions. Journal of Education, Health and Sport. 2016;6(4):141-150. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.49942
http://ojs.ukw.edu.pl/index.php/johs/article/view/3461
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016.
CLUSTER ANALYSIS OF HORMONAL CONSTELLATION AT WOMEN AND MEN WITH HARMONIOUS AND DISHARMONIOUS GENERAL ADAPTATION REACTIONS
Yaroslav L Hrytsak1, Liliya G Barylyak1,2,3, Walery Zukow4, Igor L Popovych3
1Hotel Spa Complex “Karpaty”, Truskavets’, Ukraine [email protected]
2JSC “Truskavets’kurort”, Truskavets’, Ukraine [email protected]
3Laboratory of Experimental Balneology, OO Bogomoletz Institute of Physiology NAS, Truskavets’-Kyiv, Ukraine [email protected]
4Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland [email protected]
Abstracts
Background. It is known that the nervous, endocrine and immune systems interact closely with each other to form a three-pronged neuro-endocrine-immune complex. On of manifest of causal neuroendocrine-immune relationships is Leukocytogram of peripheral blood that differ by various constellation of Principal Adaptation Hormones. Material and research methods. We determined twice at ten women and ten men aged 33-76 years without clinical diagnose serum levels of Cortisol, Aldosterone, Triiodothyronine, Testosterone and Calcitonin (ELISA) as well as Popovych’s Adaptation Index by Leukocytogram. Results. All case was distributed among four clusters. Cluster N1 contains 5 cases with drastically hypercortisolemia and moderately hypercalcitoninemia; 5 other cases characterized moderately hypercortisolemia and borderline level of Triiodothyronine, together reflected chronic stress. Majority of cases (Cluster N3) characterized upper borderline level of Cortisol and normal levels others hormones, while in 5 cases (Cluster N4) hormonal costellation is also normal but with lower borderline level of Cortisol. Estimation by Leukocytogram Popovych’s Adaptation Index shown that at 25 cases take place Harmonious General Adaptation Reactions (GAR) as markers of health while at 15 cases detected Disharmonious GAR as markers of premorbidic stage. Conclusion. Constellations of principal Adaptation Hormones displays widely variability representing different gradations of health and premobide states. Calcitonin may be considered as one of principal Adaptation Hormones.
Keywords: Cortisol, Aldosterone, Triiodothyronine, Testosterone, Calcitonin, General Adaptation Reactions
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